Cytokines Web Cytokine Receptor Classification according to Domain Composition

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The extracellar portions of cytokine receptors are usually multidomain proteins made up of one or more so-called "modules". Here the modules types that are present in cytokine receptors are illustrated, and the receptors themselves grouped according to the modules that make up the protein. You can also get the SWISS-PROT names for the domains here.

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Domain (module) types present in cytokine receptors
graphic module nomenclature based on that of P. Bork & A. Bairoch (1995) TIBS 20(3), poster C02

	Contactin-like (C) domain
	Cytokine receptor superfamily (CR) domain FOLD - fibronectin type III-like SWISSPROT name- CYTOKINE RECEPTORS N-T c. 90 residues, with 4 or 6 disulphide bonds
	Fibronectin type III domain (F3) FOLD - beta-sandwich immunuglobulin like SWISSPROT name - FIBRONECTIN TYPE-III c. 90 residues, with no disulphides
	Immunoglobulin superfamily domain (Ig) FOLD - beta-sandwich SWISSPROTname - IG-LIKE c. 100 residues with 0 to 6 disulphide bonds
	Nerve growth factor (NGF) / Tumor necrosis factor (TNF) receptor superfamily domain FOLD - disulphide-rich anti-parallel beta strands) SWISSPROT name - TNFR-CYS c. 40 residues with 6 or 8 disulphide bonds

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Receptor composition (extra-cellular portions)
Schematic diagrams representing the domain-structure of the extra-cellular portions of the receptors are shown starting from the domain furthest from the cell-membrane and ending with the domain immediately adjacent to the cell-surface. Particular cytokine receptors with given compositions are listed with each schematic.

Generic receptor module composition	Cytokine Receptors
	IL-2R (beta and gamma), IL-4R (alpha and gamma),IL-7R (alpha and gamma), GHR (B and C), EPOR (B and C)
	IL-3R (alpha),IL-5R (alpha), IL-6R (alpha + ), CNTFR (alpha), IL-12R, GM-CSFR(alpha)
	IL-6R, LIFR, OSMR, CNTFR, G-CSFR, IL-12R
	LIFR (alpha), CNTFR
	IL-3R (beta), IL-5R (beta), GM-CSF (beta)
	TNFR p55

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