The following is a description of the core curriculum

[UCHSC/ School of Pharmacy/ Pharamceutical Sciences Grad courses]

The following is a description of the core curriculum (basic science component) for the Ph.D. graduate program in Pharmaceutical Sciences at the University of Colorado School of Pharmacy.

REQUIRED COURSES

PHSC 7350 Protein Chemistry
    • Protein Structure
    • Protein Stability
    • Basic Enzymology
    • Protein Folding
    • Protein Thermodynamics
    • Mutagenesis Effects

PHSC 7345 Principles of Drug Delivery
    • Mechanisms of Drug Transport
    • Introduction to Controlled Release Drug Delivery
    • Targeted Drug Delivery
    • Drug Delivery Technology
    • Drug Delivery Across Specialized Biological Barriers

CHEN 5810(PHSC 7651)* Pharmaceutical Biotechnology
    • Mass Transport
    • Heat Transport
    • Solution Equilibria
    • Protein-Ligand Interactions

TXCL 7562 Analytical Aspects of Forensic Toxicology
    • Chromatographic Theory
    • Chromatographic Practice: GC/HPLC/TLC
    • Basics of Immunoassays
    • Principles of Mass Spectrometry
    • Blood/Breath Ethanol Measurement
    • Application of all of the above to
        legal quantitation, pharmacokinetics, and effects of ethanol/cocaine/THC/amphetamines.

PHSC 7330 Issues in Drug Development
    • General Approaches to Drug Discovery
    • Worldwide Drug Approval Process
    • Preclinical Testing
    • Animal Models
    • Formulation Strategies/Dosage Form Design
    • Manufacturing Issues/Comparability
    • Clinical Trials Design/Patient Recruitment
    • Pharmacogenetics Implications in Drug Development

TXCL 7655 Pharmacokinetics and Toxicokinetics
    • Basics of Pharmacokinetics (PK) and Drug Disposition
    • Pharmacokinetic Models
    • Dosing Regimens
    • Clinical Pharmacokinetics
    • Applications of PK in Toxicology

PHSC 7652 Principles of Medicinal Chemistry
    • Fundamentals of Structure-Activity Relationships (SAR)
    • Mechanisms of Drug Action • Rational Drug Design
    • Structure Effects of Drug Disposition
    • SAR of Various Therapeutic Classes of Drugs

*-MAY BE REPLACED WITH A COURSE IN MOLECULAR BIOLOGY
RECOMMENDED COURSES:

Electives:

PHSC 7354 Spectroscopic Analysis of Biomolecules
    • Optical Methods (CD, uv-vis, fluorescence)
    • Vibrational Methods (IR, Raman)
    • NMR
    • EPR
    • Calorimetry
    • Analytical Ultracentrifuge

Other science courses commonly taken by our students include:

	PHSC 7360 Signal Transduction (next scheduled for spring, 2000)
	PHSC 7353 Pharmacogenetics (next scheduled for spring, 2000)
	PHSC 7530 Cancer: Experimental and Medical Aspects (next offered Spring, 2001)
	BIOM 6601 Biostatistics Methods I (next offered, Fall, 1999)

PLEASE NOTE THAT CORE COURSES IN THE PHARMACEUTICAL SCIENCES ARE TAUGHT ON AN EVERY OTHER YEAR BASIS. THE CURRENT SCHEDULE FOR THESE COURSES IS GIVEN BELOW.

Planned Course Schedule for Pharmaceutical Sciences Courses:

1999-2000

	Fall - Issues in Drug Development
	Winter- Principles of Drug Delivery; Analytical Aspects of Forensic Toxicology
	Spring - Spectroscopic Analysis of Biomolecules; Pharmacogenetics; Signal Transduction

2000-2001

	Fall- Pharmaceutical Biotechnology; Pharmacokinetics and Toxicokinetics
	Winter- Protein Chemistry; Analytical Aspects of Forensic Toxicology
	Spring - Principles of Medicinal Chemistry; Cancer: Experimental and Medical Aspects

OTHER REQUIREMENTS: In addition, our students must complete:

	two research rotations (each one quarter in length, PHSC 7840),
	a course in research ethics (usually PHCL 7605, Ethics in Research)
	two classes in pharmacoeconomics (usually PHSC 7370 Business and Regulatory Issues in Pharmaceutical Biotechnology, PHSC 7325 Pharmaceutical Development or CHEN 5919, Case Studies in Biotechnology)