Research & Graduate Studies in Pharmaceutical Sciences
Robert Blouin, Pharm.D. - Associate Dean
Paul M. Bummer, Ph.D. - Director of Graduate Studies

PHR 510 MODERN METHODS IN PHARMACEUTICAL ANALYSIS. (5)

A course which deals with the application of modern analytical methods, primarily instrumental methods, in the determination of the strength, purity and quality of drugs and pharmaceuticals. Laboratory exercises include analysis of raw materials and finished dosage forms. Lecture, three hours; laboratory, four hours. Prereq: CHE 226.

PHR 530 RADIOPHARMACEUTICS. (3)

Basics of radioactive decay and detection. Labelling of molecules and cells with radionuclides. Imaging systems and clinical aspects of radiopharmaceuticals. Radioanalytical applications in pharmaceutical sciences, including position tomography and gamma scintigraphy. Development of new radiopharmaceuticals and absorbed dose calculations. The principles of radiation safety and radiobiology. Prereq: consent of instructor.

PHR 545 STERILE PARENTERALS AND DEVICES. (2-3)

The course will describe the fundamental concepts, principles and techniques involved in the characterization, development, evaluation and preparation of sterile products. Lecture, two credits; lecture with laboratory, three credits. Prereq: PHR 846 and PHR 825 or equivalent and consent of instructor.

PHR 612 QUANTITATIVE PHARMACODYNAMICS. (3)

Quantitative treatment of dynamics of drug absorption, distribution, metabolism and excretion, including development of both mathematical models and model-independent approaches for describing these processes. Prereq: PHR 802 (or equivalent), MA 114 and consent of instructor. (Same as PHA 612).

PHR 620 NATURAL PRODUCTS CHEMISTRY. (3)

Chemistry of natural products. A course designed to establish a bridge between organic chemistry, biochemistry and biology in terms of such areas as biogenesis, biotransformations, isolation, degradation, structure elucidation, and synthesis of natural products of interest as medicinal agents. Prereq: PHR 400 or equivalent and consent of instructor.

PHR 622 ADVANCED BIOPHARMACEUTICS. (2)

Advanced treatment of factors affecting drug availability from dosage forms and the influence of the route of administration and the dosage regimen on drug availability. Prereq: PHR 612.

PHR 630 PHARMACEUTICAL RATE PROCESSES. (3)

Kinetics of reactions of pharmaceutical interest; mechanisms of drug decomposition and theoretical approaches to stabilization and preservation; accelerated stability analysis. Prereq: physical chemistry and chemical kinetics.

PHR 631 EQUILIBRIUM PHENOMENA IN PHARMACEUTICAL SYSTEMS. (3)

An advanced study in special topics of a physical chemical nature which are applicable to pharmacy, with special emphasis on physical properties and molecular structure, solubility, complexation and equilibria in solution. Prereq: physical chemistry.

PHR 645 NEUROTOXICOLOGY. (2)

Multidisciplinary discussions of the major sits and mechanisms of drug/chemical-induced nervous-system toxicity. Presentations by faculty and graduate students. Prereq: BCH 501 and 502, PGY 502 and PHA 522 or equivalent, and consent of instructor. (Same as TOX 645.)

PHR 647 INTRODUCTION TO MOLECULAR PHARMACOTHERAPEUTICS. (3)

A discussion of the development of potential therapeutic entities using molecular biotechnology, Recent advances in the design and delivery of target-specific treatments such as special peptides, monoclonal antibodies and gene therapies will be the primary focus. Prereq: BCH 501 and 502, BCH 401G or equivalent, or consent of instructor.

PHR 649 MOLECULAR PHARMACOLOGY. (3)

The intent of this course is to describe the molecular aspects of a variety of physiological systems that are subject to pharmacological manipulation. Emphasis will be on the molecular genetics, biochemistry and subcellular organization and biology of these systems, and on the pharmacological techniques used to study these systems. Genetic diseases associated with these systems will also be described. The course will focus on areas of research which represent the forefront of modern pharmacological investigation. Prereq: PHA 522, PGY 502, BCH 501, 502, or consent of instructor. (Same as PHA/TOX 649).

PHR 664 THEORY AND PRACTICE OF DRUG METABOLISM. (3)

A broad overview of the chemistry of drug biotransformation, with emphasis on experimental considerations and analytic methodology for the isolation and identification of metabolites and the study of metabolic processes. Prereq: BCH 501 and CHE 538, or consent of instructor.

PHR 668 PSYCHOTHERAPEUTICS FOR ADVANCED NURSING PRACTICE. (3)

This course provides advanced background in psychotherapeutics for psychiatric/mental health nurse practitioners. Psychiatric disorders and their pharmacology are addressed, with emphasis on indications for use, mechanisms of action, side effects, pharmacokinetics and nursing management problems. Prereq: graduate standing in nursing, or permission of instructor. (Same as NUR 668.)

PHR 748 MASTER'S THESIS RESEARCH (0)

Half-time to full-time work on thesis. May be repeated to a maximum of six semesters. Prereq: All course work toward the degree must be completed.

PHR 749 DISSERTATION RESEARCH. (0)

Half-time to full-time work on dissertation. May be repeated to a maximum of six semesters. Prereq: registration for two full-time semesters of 769 residence credit following the successful completion of the qualifying exams.

PHR 760 TOPICS IN PHARMACEUTICAL SCIENCES. (2-4)

This course deals with emerging concepts in pharmaceutical sciences which are not being covered in other courses. May be repeated to a maximum of 10 hours. Prereq: consent of instructor.

PHR 762 BIOORGANIC MECHANISMS. (3)

An in-depth discussion on the bioorganic chemistry aspects of the active sites of enzymes and drug receptors, the molecular base of drug design, and principles of drug metabolism. Within these topics, the mode of action of some of the major coenzymes and drugs will be discussed from a mechanistic chemistry point of view. Prereq: CHE 538, CHE 633, BCH 501, or consent of instructor.

PHR 768 RESIDENCE CREDIT FOR THE MASTER'S DEGREE. (1-6)

May be repeated to a maximum of 12 hours.

PHR 769 RESIDENCE CREDIT FOR THE DOCTOR'S DEGREE. (0-12)

May be repeated indefinitely.

PHR 774 GRADUATE SEMINAR IN PHARMACOLOGY/EXPER. THERAPEUTICS. (1)

Reports/discussion of current research and literature of general interest in pharmacology and experimental therapeutics. The grade will be based on the presentation of the required annual seminar, which will be objectively evaluated by the faculty of the Pharmaceutical Sciences division. May be repeated to a maximum of eight credits Prereq: graduate standing.

PHR 776 SEMINAR IN PHARMACEUTICAL SCIENCES I. (1)

Reports and discussion of pertinent research and literature in a disciplinary area of the pharmaceutical sciences. Required of all graduate students. Prereq: graduate standing.

PHR 778 SEMINAR IN PHARMACEUTICAL SCIENCES II. (1)

Reports and discussion of pertinent research and literature in a disciplinary area of the pharmaceutical sciences. May be repeated to an eight-credit maximum. Prereq: graduate standing.

PHR 779 MEMBRANE SCIENCES COLLOQUIUM. (1)

Outstanding membrane scientists present their current research on biological and/or synthetic membranes. Students read a pertinent paper by the speaker prior to his/her talk and write a short paper on the talk; especially important is the relevance of the main points of the talk to membrane science in general and the student's own research in particular. May be repeated to a maximum of six credits. (Same as BCH/CHE/CME/PHA 779).

PHR 780 SPECIAL PROBLEMS IN PHARMACEUTICAL SCIENCES. (1-6)

Selected problems of laboratory or literature nature in which a student pursues a topic of interest to him under the supervision of a faculty member particularly qualified in that area. May be repeated once. Prereq: consent of instructor.

PHR 790 RESEARCH IN PHARMACEUTICAL SCIENCES. (1-12)

Research work to be conducted in selected areas of pharmaceutical sciences. Prereq: approval of student's special committee and consent of instructor.

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Room 409 Pharmacy Bldg. - Rose Street, Lexington, KY 40536-0082 - Phone (859) 257-1998 - Fax (859) 257-7564