Number of amino acids: 4382

Molecular weight: 486372.7

Theoretical pI: 5.91

Amino acid composition:

Ala (A) 325	  7.4%
Arg (R) 146	  3.3%
Asn (N) 214	  4.9%
Asp (D) 221	  5.0%
Cys (C) 144	  3.3%
Gln (Q) 147	  3.4%
Glu (E) 240	  5.5%
Gly (G) 269	  6.1%
His (H)  86	  2.0%
Ile (I) 212	  4.8%
Leu (L) 444	 10.1%
Lys (K) 258	  5.9%
Met (M) 111	  2.5%
Phe (F) 195	  4.5%
Pro (P) 166	  3.8%
Ser (S) 298	  6.8%
Thr (T) 320	  7.3%
Trp (W)  45	  1.0%
Tyr (Y) 184	  4.2%
Val (V) 357	  8.1%

Asx (B)   0	  0.0%
Glx (Z)   0	  0.0%
Xaa (X)   0	  0.0%

Total number of negatively charged residues (Asp + Glu): 461
Total number of positively charged residues (Arg + Lys): 404

Atomic composition:

Carbon      C	     21746
Hydrogen    H	     34030
Nitrogen    N	      5656
Oxygen      O	      6468
Sulfur      S	       255

Formula: C21746H34030N5656O6468S255
Total number of atoms: 68155

Extinction coefficients:

Conditions: 6.0 M guanidium hydrochloride
            0.02 M phosphate buffer
            pH 6.5

Extinction coefficients are in units of  M-1 cm-1 .

The first table lists values computed assuming ALL Cys 
residues appear as half cystines, whereas the second table 
assumes that NONE do. 

                      276     278     279     280     282
                       nm      nm      nm      nm      nm
Ext. coefficient   520240  518744  510820  500210  481440
Abs 0.1% (=1 g/l)   1.070   1.067   1.050   1.028   0.990



                      276     278     279     280     282
                       nm      nm      nm      nm      nm
Ext. coefficient   509800  509600  502180  491570  472800
Abs 0.1% (=1 g/l)   1.048   1.048   1.033   1.011   0.972


Estimated half-life:

The N-terminal of the sequence considered is M (Met).

The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro).
                            >20 hours (yeast, in vivo).
                            >10 hours (Escherichia coli, in vivo).


Instability index:

The instability index (II) is computed to be 35.51
This classifies the protein as stable.



Aliphatic index: 89.43

Grand average of hydropathicity (GRAVY): -0.020