SARS冠状病毒蛋白质初步分析(1)

张其鹏,石磊,芮伟,卢铭
(北京大学医学部生物信息组 100083)

背景:根据前文,我们分析SARS冠状病毒基因组可以编码25个蛋白质(11个cds,其中一个cds:putative orf1ab polyprotein, 编码了一个多聚蛋白质,这个蛋白由14个蛋白组成,见图)。

目的:通过运用生物信息学的工具,对这25个蛋白进行序列上的分析,试图根据分析结果推测蛋白质的功能和在SARS发病过程中的作用。

方法与结果:我们运用SIB 提供的ScanPrositeProtParam对这25个蛋白进行分析,推测计算出了这些蛋白的等电点、分子量、分子式、消光系数、氨基酸残基组分比、不稳定系数值等物理特性参数,还推测出这些蛋白的生物学功能区(如:磷酸化位点、半胱氨酸富集区、糖基化位点等)。结果见表

    Analysis Result of SARS Coronavirues Proteins

    Location Product Protein Assession No. Analysis Result
    250..21470 putative orf1ab polyprotein NP_828849.1 See Details
    250..13398 orf1a polyprotein NP_828850.1 See Details
    21477..25244 putative E2 glycoprotein precursor;putative spike glycoprotein NP_828851.1 See Details
    25253..26077 putative uncharacterized protein NP_828852.1 See Details
    25674..26138 putative uncharacterized protein NP_828853.1 See Details
    26102..26332 putative small envelope protein E NP_828854.1 See Details
    26383..27048 putative protein M NP_828855.1 See Details
    27059..27250 putative uncharacterized protein NP_828856.1 See Details
    27258..27626 putative uncharacterized protein NP_828857.1 See Details
    28105..29373 putative nucleocapsid protein NP_828858.1 See Details
    28115..28411 putative uncharacterized protein NP_828859.1 See Details
    250..786 putative leader protein NP_828860.1 See Details
    787..2703 putative counterpart of MHV p65 protein NP_828861.1 See Details
    2704..9969 putative coronavirus nsp1 NP_828862.1 See Details
    9970..10887 putative coronavirus nsp2 (3CL-PRO) NP_828863.1 See Details
    10888..11757 putative coronavirus nsp3 (HD2) NP_828864.1 See Details
    11758..12006 putative coronavirus nsp4 NP_828865.1 See Details
    12007..12600 putative coronavirus nsp5 NP_828866.1 See Details
    12601..12939 putative coronavirus nsp6 NP_828867.1 See Details
    12940..13356 putative coronavirus nsp7 NP_828868.1 See Details
    13357..13383,13383..16151 putative coronavirus nsp9 (RdRp) NP_828869.1 See Details
    16152..17954 putative coronavirus nsp10 (MB, NTPase/HEL) NP_828870.1 See Details
    17955..19535 putative coronavirus nsp11 NP_828871.1 See Details
    19536..20573 putative coronavirus nsp12 NP_828872.1 See Details
    20574..21467 utative coronavirus nsp13 NP_828873.2 See Details
    Figure1. SARS Covonavirus Model
    (Click item to see details)

 

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2003-4-29