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Opportunities and Challenges:
A Focus on Future Stem
Cell Applications
The makings of future news headlines about tomorrow's
life saving therapies starts in the biomedical research laboratory. Ideas
abound; early sucesses and later failures and knowledge gained from both;
the rare lightning bolt of an unexpected breakthrough discovery — this is
a glimpse of the behind the scenes action of some of the world's most
acclaimed stem cell scientists' quest to solve some of the human body's
most challenging mysteries.
Stem cells — what lies ahead? The following chapters
explore some of the cutting edge research featuring stem cells. Disease
and disorders with no therapies or at best, partially effective ones, are
the lure of the pursuit of stem cell research. Described here are examples
of significant progress that is a prologue to an era of medical discovery
of cell-based therapies that will one day restore function to those whose
lives are now challenged every day — but perhaps in the future, no
longer.
Contents
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Preface |
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Executive
Summary |
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Chapter 1:
The Stem Cell |
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Chapter 2:
The Embryonic Stem Cell |
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Chapter 3:
The Human Embryonic Stem Cell and The Human Embryonic Germ
Cell |
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Chapter 4:
The Adult Stem Cell |
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Chapter 5:
Hematopoietic Stem Cells |
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Chapter 6:
Autoimmune Diseases and the Promise of Stem Cell-Based
Therapies |
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Chapter 7:
Stem Cells and Diabetes |
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Chapter 8:
Rebuilding the Nervous System with Stem Cells |
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Chapter 9:
Can Stem Cells Repair a Damaged Heart? |
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Chapter
10: Assessing Human Stem Cell Safety |
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Chapter
11: Use of Genetically Modified Stem Cells in Experimental Gene
Therapies |
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Appendix
A: Early Development |
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Appendix
B: Mouse Embryonic Stem Cells |
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Appendix
C: Human Embryonic Stem Cells and Embryonic Germ Cells |
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Appendix
D: Stem Cell Tables |
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i. Published Reports on Isolation and
Differentiation of Mouse Stem Cells |
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ii. Published Reports on Isolation
and Differentiation of Human Fetal Tissue Germ Cells |
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iii. Published Reports on Isolation
and Differentiation of Human Embryonic Stem Cells |
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iv. Published Reports on Isolation
and Differentiation of Human Embryonic Carcinoma Stem Cells |
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v. Published Reports on Isolation and
Differentiation of Human Adult Stem Cells |
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vi. References |
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Appendix
E: Stem Cell Markers |
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i. Markers: How Do Researchers Use
Them to Identify Stem Cells? |
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ii. Commonly Used Markers to Identify
Stem Cells and Characterize Differentiated Cell Types |
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Appendix
F: Glossary and Terms |
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i. Glossary |
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ii. Terms |
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Appendix
G: Informational Resources |
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i. Persons Interviewed |
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ii. Special Contributions |
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iii.
Acknowledgments |
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