Cancer Gene Therapy
Molecular genetics has
spawned an impressive outpouring of insights into the biology of neoplastic
transformation and the host-tumor relationship. This deeper understanding of
cancer pathogenesis presents a rich opportunity to develop novel therapeutic
agents with improved selectivity for cancer cells.
One promising approach involves gene therapy, which is the introduction of
genetic material into a patient's tissues with the intent to achieve therapeutic
benefit. A number of gene transfer systems have been designed that enable the
genetic modification of relevant target cells, albeit with varying strengths and
limitations. Several strategies to exploit gene transfer as a tool to target
specific molecular defects intrinsic to cancer cells, enhance tumor
chemosensitivity, and augment tumor immunogenicity are under intensive
investigation. A number of these approaches have entered initial clinical
testing and already provide intriguing new information about the biology of
cancer in patients.
General Reviews and websites on Cancer Gene Therapy
Gene therapy scores against cancer W. F RENCH ANDERSON
Cancer gene therapy: hard lessons and new courses
Improving enzymes for cancer gene therapy
Gene Therapy--The Next Generation
Eighth International Conference on Gene Therapy of Cancer
On Specific Diseases
Current Therapy for Brain Tumors
Gene
therapy strategies for colon cancer
New
Molecular Strategies to Cure Brain Tumors
Targeting in Gene Therapy for Gliomas
The
Current Status of Gene Therapy for Prostate Cancer
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