Cardiovascular Gene Therapy

Cardiovascular Gene Therapy

The past two decades have seen an explosion both in our understanding of mammalian gene structure and also in our ability to manipulate DNA sequences. This, coupled with an increased understanding of the nuances of gene transfer, has clearly ushered in an era of gene therapy. The treatment of clinical cardiovascular disease has lagged somewhat behind the treatment of infectious and proliferative cellular disorders because of the polygenic nature and complex biology of many of the more common cardiac disorders, however, strategies are now developing that should allow the application of gene therapy approaches to many cardiovascular disorders.

The following reviews discussed several central issues in gene therapy, including the choice and design of gene targeting vectors and the practical and theoretical limitations of gene therapy, current progress toward gene therapy for a variety of cardiovascular diseases .

Gene Therapy for Cardiovascular Disease --2000

Gene Therapy - The Good, the Bad, and the Ugly

Gene Therapy A New Era for Cardiovascular Gene Therapy

Gene Therapy Adenovirus-Based Phospholamban Antisense Expression as a Novel Approach to Improve Cardiac Contractile Dysfunction

Gene Therapy for Common Acquired Diseases of the Heart

Gene Therapy for Hypertension

Gene Therapy for Restenosis

Gene Therapy in ApoE-Deficient Mice - ApoE Expression in the Artery Wall Reduces Early Foam Cell Lesion Formation

gene therapy-A Novel Nonangiogenic Cardiovascular Role for Vascular Endothelial Growth Factor

gene therapy-Adenoviral RB2-p130 Gene Transfer Inhibits Smooth Muscle Cell Proliferation and Prevents Restenosis

gene therapy-Adenovirus-Mediated Delivery of Fas Ligand Inhibits Intimal Hyperplasia

gene therapy-Adenovirus-Mediated Gene Transfer of a Secreted Form of Human Macrophage Scavenger Receptor Inhibits Modified Low-Density Lipoprotein Degradation and Foam-Cell Formation

gene therapy-Adenovirus-Mediated Human Tissue Kallikrein Gene Delivery Inhibits Neointima Formation

gene therapy-Adenovirus-Mediated VEGF121 Gene Transfer Stimulates Angiogenesis in Normoperfused Skeletal Muscle and Preserves Tissue Perfusion After Induction of Ischemia

gene therapy-Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1-VP16 Hybrid Transcription Factor

gene therapy-Angiotensin I–Converting Enzyme Antisense Gene Therapy Causes Permanent Antihypertensive Effects

gene therapy-Bradykinin B1 Receptor Mediates Inhibition of Neointima Formation

gene therapy-Cardiac-Directed Adenylyl Cyclase Expression Improves Heart Function in Murine Cardiomyopathy

gene therapy-Cell Transplantation as Future Therapy for Cardiovascular Disease

gene therapy-Chimeric DNA-RNA Hammerhead Ribozyme to Proliferating Cell Nuclear Antigen Reduces Stent-Induced Stenosis

gene therapy-Complete Atherosclerosis Regression After Human ApoE Gene Transfer

gene therapy-Delivery Strategies to Achieve Therapeutic Myocardial Angiogenesis

gene therapy-Efficacy of phVEGF165 Gene Transfer for Therapeutic Angiogenesis in Chronic Myocardial Ischemia

gene therapy-Efficient and Stable Transduction of Cardiomyocytes After Intramyocardial Injection or Intracoronary Perfusion With Recombinant Adeno-Associated Virus Vectors

gene therapy-eNOS Gene Transfer Inhibits Smooth Muscle Cell Migration

gene therapy-Establishment of a Simple and Practical Procedure Applicable to Therapeutic Angiogenesis

gene therapy-Experimental Models to Vascular Gene Transfer Strategies

gene therapy-GATA-6- The Proliferation Stops Here - Cell Proliferation in Glomerular Mesangial and Vascular Smooth Muscle Cells

gene therapy-Gene Targets and Approaches for Raising HDL

gene therapy-Gene Transfer and Hepatic Overexpression of the HDL Receptor SR-BI Reduces Atherosclerosis

gene therapy-Gene Transfer of Endothelial Nitric Oxide Synthase Improves Relaxation of Carotid Arteries

gene therapy-Gene Transfer of Human Prostacyclin Synthase Ameliorates Monocrotaline-Induced Pulmonary Hypertension

gene therapy-In Vivo Gene Transfer of Endothelial Nitric Oxide Synthase Enhances Endothelium-Dependent Relaxations

gene therapy-Inability to Induce Hypertension in Normotensive Rat Expressing AT1 Receptor Antisense

gene therapy-Inhibition of Late Vein Graft Neointima Formation in Human and Porcine Models by Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-3

gene therapy-Inhibition of Matrix Metalloproteinases by Lung TIMP-1 Gene Transfer Pulmonary Hypertension

gene therapy-Intracoronary Delivery of Adenovirus Encoding Adenylyl Cyclase VI Increases Left Ventricular Function

gene therapy-Intravascular Adenovirus-Mediated VEGF-C Gene Transfer Reduces Neointima Formation

gene therapy-Kallikrein Gene Delivery Attenuates Myocardial Infarction

gene therapy-Kallikrein Gene Delivery Inhibits Vascular Smooth Muscle Cell Growth and Neointima Formation

gene therapy-Local Expression of Bovine Decorin by Cell-Mediated Gene Transfer Reduces Neointimal Formation

gene therapy-Local Overexpression of Thrombomodulin for In Vivo Prevention of Arterial Thrombosis

gene therapy-Long-Term Antihypertensive Action by Virally Mediated Delivery of ACE Antisense cDNA

gene therapy-Overexpression of G Protein–Coupled Receptor Kinase-2 in Smooth Muscle Cells Attenuates Mitogenic Signaling via G Protein–Coupled and Platelet-Derived Growth Factor Receptors

gene therapy-Prospects for Gene Therapy for Heart Failure

gene therapy-Prostacyclin Synthase Gene Transfer Accelerates Reendothelialization and Inhibits Neointimal Formation

gene therapy-Restoration of Diastolic Function in Senescent Rat Hearts Through Adenoviral Gene Transfer of Sarcoplasmic Reticulum Ca2+-ATPase

gene therapy-The Promise of Cardiovascular Gene Therapy

gene therapy-The Role of Gene Therapy for Intimal Hyperplasia

gene therapy-Therapeutic Myocardial Angiogenesis Via Vascular Endothelial Growth Factor Gene Therapy

gene therapy-Vascular Endothelial Growth Factor165 Gene Transfer Augments Circulating Endothelial Progenitor Cells in Human Subjects

gene therapy-Vascular Gene Transfer

genetherapy-Gene Transfer of Calcitonin Gene–Related Peptide Prevents Vasoconstriction After Subarachnoid Hemorrhage

In Vivo Gene Transfer of Prepro-Calcitonin Gene–Related Peptide to the Lung Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension