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Welcome to the on-line resource for Hypertension Candidate Genes. Below is a list of 150 candidate genes.
Each gene is clickable and will open to a new web page showing all available data collected.
Available data includes map location and genetic interval, OMIM number, sequence data, and expression data for each gene.
If you would like a tab-delimited text file of this information, click here.
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| List By Gene Names | List By Gene Symbols | GIST | |
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| Genes sorted by functional class |
| Apolipoproteins | Channels and Transporters | Cytoskeletal and Adhesion Molecules | Endothelins |
| Fat and Lipid Regulation | Glucose Regulation | Growth Factors and Hormones |
| Hypothalamus-Pituitary Axis | Intracellular Messengers | Kallikrein-Kinin pathway | Natriuretic Peptides |
| Renin-Angiotensin-Aldosterone pathway | Steroids | Sympathetic Nervous System |
| Thromboxanes and Prostaglandins | Miscellaneous |
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| Apolipoproteins |
| Apolipoprotein A1 (APOA1) |
| Apolipoprotein A2 (APOA2) |
| Apolipoprotein C2 (APOC2) |
| Apolipoprotein C3 (APOC3) |
| Apolipoprotein C4 (APOC4) |
| Apolipoprotein E (APOE) |
| Apolipoprotein E Receptor 2 (APOER2/LRP8) |
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| Channels / Transporters |
| Aquaporin 2 (AQP2) |
| ATP-Sensitive K Channel (KCNJ6) |
| Cardiac L type Calcium Channel, alpha-1 (CACNA1C/CACNL1A1) |
| Chloride Bicarb. Exchanger 1 (AE1/SLC4A1) |
| Chloride Bicarb. Exchanger 2 (AE2/SLC4A2) |
| Chloride Bicarb. Exchanger 3 (AE3/SLC4A3) |
| Chloride Channel, kidney, A (CLCNKA) |
| Chloride Channel, kidney, B (CLCNKB) |
| Glucose Transporter 1 (GLUT1/SLC2A1) |
| Glucose Transporter 2 (GLUT2/SLC2A2) |
| Glucose Transporter 3 (GLUT3/SLC2A3) |
| Glucose Transporter 4 (GLUT4/SLC2A4) |
| Potassium-chloride cotransporter (hKCC1) |
| Sodium Bicarbonate Cotransporter (NBC/HNBC1) |
| Sodium Calcium Exchanger 1 (NCX1/SLC8A1) |
| Sodium Calcium Exchanger 2 (NCX2/SLC8A2) |
| Sodium Channel (SCNN1A) |
| Sodium Channel (SCNN1B) |
| Sodium Channel (SCNN1D) |
| Sodium Channel (SCNN1G) |
| Sodium Channel - Heart (SCN5A) |
| Sodium Chloride Cotransporter (SLC12A3/HTSC) |
| Sodium Hydrogen Exchanger 1 (NHE1/SLC9A1) |
| Sodium Hydrogen Exchanger 2 (NHE2/SLC9A2) |
| Sodium Hydrogen Exchanger 5 (NHE5/SLC9A5) |
| Sodium Potassium ATPase alpha1 (ATP1A1) |
| Sodium-Glucose Cotransporter, renal (SGLT2/SLC5A2) |
| B-cell K/ATP Channel (BIR/KCNJ11) |
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| Cytoskeletal / Adhesion Molecules |
| Adducin - alpha (ADD1) |
| Adducin - beta (ADD2) |
| Adducin - gamma (ADD3) |
| E-Selectin (ELAM/SELE) |
| Intercellular Adhesion Molecule 1 (ICAM1) |
| Intercellular Adhesion Molecule 2 (ICAM2) |
| Intercellular Adhesion Molecule 3 (ICAM3) |
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| Endothelins |
| Endothelin 1 (EDN1/ET1) |
| Endothelin 2 (EDN2/ET2) |
| Endothelin 3 (EDN3/ET3) |
| Endothelin Convert. Enzyme1 (ECE1) |
| Endothelin Receptor Type A (EDNRA) |
| Endothelin Receptor Type B (EDNRB) |
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| Fat and Lipid Regulation |
| Bombesin-like Receptor 3 (BRS3) |
| LDL Receptor (LDLR) |
| Leptin (LEP/OB) |
| Leptin Receptor (LEPR) |
| Lipoprotein Lipase (LPL) |
| Uncoupling Protein 3 (UCP3) |
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| Glucose Regulation |
| Aldose Reductase (ALDR1) |
| Amylin (IAPP) |
| Gastric Inhibitory Polypeptide Receptor (GIPR) |
| Glucagon (GCG) |
| Glucagon Receptor (GCGR) |
| Glucagon-like Peptide 1 Receptor (GLP1R) |
| Glucokinase-liver (GCK) |
| Glutamine:F6P Amidotransferase (GFAT/GFPT) |
| Glycogen Synthase-liver (GYS2) |
| Glycogen Synthase-muscle (GYS1) |
| Insulin (INS) |
| Insulin Promoter Factor/ Somatostatin TF (IPF1/IDX1/STF1) |
| Insulin Receptor (INSR) |
| Insulinlike Growth Factor 1 (IGF1) |
| Insulinlike Growth Factor 2 (IGF2) |
| Sulfonylurea Receptor (SUR) |
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| Growth Factors and Hormones |
| Adrenomedullin (ADM/AM) |
| Calcitonin/Calcitonin Gene Related Peptide (CGRP/CALCA) |
| Glucocorticoid Receptor (GRL) |
| Growth Hormone 1 (GH1) |
| Growth Hormone 2 (GH2) |
| Thyrotropin Releasing Hormone (TRH) |
| Thyrotropin Releasing Hormone Receptor (TRHR) |
| Parathyroid Hormone Receptor (PTHR1) |
| Parathyroid Hormone-Related Protein (PTHRP/PTHLH) |
| Vascular Endothelial Growth Factor A (VEGFA) |
| Vascular Endothelial Growth Factor B (VEGFB) |
| Vascular Endothelial Growth Factor C (VEGFC) |
| Transforming Growth Factor Beta 1 (TGFB1) |
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| Hypothalamus-pituitary axis |
| Arginine Vasopressin (AVP) |
| Arginine Vasopressin Receptor 1A (AVPR1A) |
| Arginine Vasopressin Receptor 1B (AVPR1B) |
| Arginine Vasopressin Receptor 2 (AVPR2) |
| Galanin (GALN) |
| Galanin Receptor (GALNR) |
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| Intracellular Messengers |
| Gi, alpha subunit (GNAI1) |
| G-protein, beta polypeptide 3 (GNB3) |
| Nitric Oxide Synthase, endothelial (NOS3) |
| Nitric Oxide Synthase, inducible (NOS2/NOS2A) |
| Nitric Oxide Synthase, neuronal (NOS1) |
| Protein Kinase C isozyme-Epsilon (PRKCE) |
| Protein Kinase C isozyme-Theta (PRKCQ) |
| Protein Phosphatase 1, gamma subunit (PPP1G) |
| Protein Phosphatase 1, alpha subunit (PPP1A) |
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| Kallikrein-Kinin pathway |
| Bradykinin Receptor B2 (BDKRB2/BKRB2) |
| Kallikrein, glandular (KLK1) |
| Kallistatin (KST/PI4) |
| Kininogen (KNG) |
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| Natriuretic Peptides |
| Atrial Natriuretic Peptide (NPPA/ANP) |
| Brain Natriuretic Peptide (NPPB/BNP) |
| Natriuretic Peptide Receptor A/Guanyl Cyclase A (NPR1/ANPRA) |
| Natriuretic Peptide Receptor B (NPR2/ANPRB) |
| Natriuretic Peptide Receptor C (NPR3/ANPRC) |
| Natriuretic Peptide type C (NPPC/CNP) |
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| Renin-angiotensin-aldosterone system |
| Aldosterone Synthase B1 (CYP11B1) |
| Aldosterone Synthase B2 (CYP11B2) |
| Angiotensin Converting Enzyme (ACE) |
| Angiotensin II Receptor 1 (AT2R1) |
| Angiotensin II Receptor 2 (AT2R2) |
| Angiotensinase C/Prolyl-CPY (PRCP) |
| Angiotensinogen (AGT) |
| Chymase, heart (CYH) |
| Renin (REN) |
| Renin-Binding Protein (RENBP) |
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| Steroids |
| 11-Beta Hydroxysteroid Dehydrogenase B1 (HSD11B1) |
| 11-Beta Hydroxysteroid Dehydrogenase B2 (HSD11B2) |
| 17 Alpha Hydroxylase (CYP17) |
| Cytochrome P450-4A (CYP4A11) |
| Mineralocorticoid Receptor (MLR) |
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| Sympathetic Nervous System |
| Alpha 1A Adrenergic Receptor (ADRA1A) |
| Alpha 2A Adrenergic Receptor (ADRA2A) |
| Beta 2 Adrenergic Receptor (ADRB2) |
| Beta 3 Adrenergic Receptor (ADRB3) |
| Dopamine Beta-Hydroxylase (DBH) |
| Dopamine Receptor D1 (DRD1) |
| Neuropeptide Y (NPY) |
| Neuropeptide Y Receptor 1 (NPY1R) |
| Norepinephrine Transporter Protein 1 (NET1/SLC6A2) |
| Phenylethanolamine N-Methyltransferase (PNMT) |
| Tyrosine Hydroxylase (TH) |
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| Thromboxanes and Prostaglandins |
| Cyclooxygenase 1 (COX1/PTGS1) |
| Cyclooxygenase 2 (COX2/PTGS2) |
| Phospholipase A2 (PLA2/PLA2A/PLA2G1B) |
| Prostacyclin Synthase (PGIS/PTGIS) |
| Prostacyclin Receptor (PTGIR) |
| Prostaglandin E Receptor 2 (PTGER2) |
| Prostaglandin E Receptor 3 (PTGER3) |
| Thromboxane A Synthase (TBXAS1) |
| Thromboxane A2 Receptor (TBXA2R) |
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| Miscellaneous |
| Adenosine A1 Receptor (ADORA1) |
| Adenosine A2A Receptor (ADORA2A) |
| Methylenetetrahydrofolate Reductase (MTHFR) |
| Subtractive Clone A (SA/SAH) |
| Cdc42-Interacting Protein 4 (CIP4) |
| Haptoglobin (HAPT/HP) |
| Thrombin Receptor (TR/CF2R/PAR1/F2R) |
| List By Gene Symbols | List By Gene Name | GIST | Chakravarti Lab | |