Copper Mountain
PRELIMINARY PROGRAMS FOR 2000

5 June. Human Hemodynamic Changes During Pregnancy. J.F. Clapp, III, K.L. Thornburg, M. Lindheimer, S. Schroff, A. Chapman, J. Davison, L. Peeters. Humoral Environment and Regulation of Smooth Muscle Contractility and Reactivity. G. Pepe, J. Brayden, I.M. Bird, C. Yallampalli.

6 June. Placental and Uterine Angiogenesis During Pregnancy. L.P. Reynolds, R.R. Magness, A. Ahmed, E.D. Albrecht, K.P. Conrad. Uterine, Placental and Fetal Vascular Reactivity. L. Poston, R.R. Magness, L. Myatt, L. Zhang, G. Osol, P.W. Shaul.

7 June. Embryonic and Fetal Cardiovascular Development: Structure and Function. S.L. Adamson, M. Kirby, J. Rossant, B.L. Langille, J.L. Segar, J.J. Faber, C. Martyn. Fetal Environment and Cardiovascular Development. S.L. Adamson, C. McMillen, M.A. Hanson, L. Woods.

8 June. Cardiovascular Adaptations in the Newborn. W. Hay, Jr., D. Teitel, B. Ascuitto, N. Ross-Asciutto, G. Giraud, R. Clyman, S. Abman. Pathophysiology in Pregnancy. J. Roberts, L. Davis, G. Chaudhuri, L. Moore.

9 June. Placental Transport and Fetal Nutrition. K. L. Thornburg, R.D.H. Boyd, N. Illsley, J. Hunt, C. Sibley, R. Brace, J. Harding, J. Challis, E. Lumbers.

 

AMYLOIDS AND OTHER PROTEIN ASSEMBLY PROCESSES June 11-16 Organizers: Susan L. Lindquist, Paul E. Fraser

11 June. Keynote Address. D. Cleveland, J. Kelly.

12 June. From in vitro Studies to Animal Models. N. Bonini, K. Duff, P. Lansbury, R. Morimoto. Amyloid Organization and Structure. D. Kirschner, H. Saibil, L. Serpell, M. Sunde.

13 June. Protein Folding and Degradation. U. Hartl, R. Kopito, P. Thomas, D. Williams. Protein Folding and Misfolding in Beta Transitions. T. Fink, D. Lynn, L. Regan.

14 June. Amyloids and Protein-based Inheritance. Y. Chernoff, S. Lindquist, J. Weissman, R. Wickner. Protein Misfolding Diseases and Physiological Consequences. M. Polymeropoulos, C. Ross, S. Sisodia, E. Wanker.

15 June. Amyloid Accessory Factors and Design of Therapeutics. M. Findeis, S. Janciauskiene, H. LeVine, M. Pepys, R. Wetzel. Conformational/Conversion Processes. B. Caughey, P. Fraser, J. King, S. Radford.

16 June. Hereditary and Systemic Amyloidosis. A. Clarke, R. Kisilevsky, G. Merlini, M. Saraiva.

Supported in part by:
Neurochem, Inc.
Parke-Davis/Warner Lambert

NEURAL-IMMUNE INTERACTIONS IN INJURY AND DISEASE: PATHWAYS TO THERAPY
June 18-23
Organizers: Etty (Tika) Benveniste, Michal Schwartz

18 June. Keynote Address. C. Shatz.

19 June. Autoimmunity in the CNS. I. Cohen, A. Fontana, V. Kuchroo, S. Miller, V. Tuohy, H. Wekerle. Neuroimmune Responses to CNS Trauma. R. Hart, R. Nitsch, M. Schwartz.

20 June. Dialog Between Glial and Immune Cells. F. Aloisi, E. Benveniste, J. Berman, R. Maki, H. Neumann, V.W. Yong. Basic Mechanisms of Neuroimmune Modulation. J.W. Streilin, E. Sternberg.

21 June. Crosstalk Between Cytokines, Neuro-trophins and Neuropeptides. W. Friedman, D. Ganea, G.M. Jonakit, M. Levite, J. Merrill, U. Otten, P. Patterson.

22 June. Immunodegenerative and Demyelinating Diseases. S. Barnum, H. Gendelman, M. Rodriguez, N. Ruddle, J.P.-Y. Ting, H. Weiner. Short oral presentations from selected posters.

23 June. Inflammatory Mediators in the CNS. Speakers to be announced.

Supported in part by: Hoechst Marion Roussel

RETINOIDS
June 25-30
Organizers: Joseph Napoli, Anton Jetten

25 June. Plenary Lecture: The Use of Gene Knockouts - Impact, Problems, and Future. P. Chambon.

26 June. Biological Activation of Retinoids. D. Ong, S. Ruff, N. Ghyselinck, M. Simon, J. Buch, M. Newcomer. Retinoid Transport and Metabolism. J. Saari, D. Bok, U. Ericksson, B. Blaner, T.M. Redmond, G. Travis.

27 June. Mechanisms of Regulating Transcription. N. Noy, C. Chomienne, R. Roeder, D. Moras. Biological Functions of Retinoid X Receptors. P. Davies, R. Evans, T. Perlmann.

28 June. Retinoid Target Genes. A. Jetten, R. Lotan, L. Gudas, U. Hammerling. Retinoids in Vertebrate Development. S. Smith, G. Eichele, M. Maden, C. Mendelsohn, P. McCaffery, S. Sockanathan.

29 June. Retinoid Effects on Cell Growth and Apoptosis. L. De Luca, M. Pfahl, D. Soprano, X.-K. Zhang. Retinoids in Health and the Immune Process. J. Olson, B. Arnason, K. Ozato.

30 June. Oral Presentations of Selected Posters. Selection Committee: C. Ross, F. Chytil, E. Harrison. Ten to twelve poster presenters will be chosen to make oral presentations. Selections will be made from exciting new work not represented on the oral program. Independent young investigators are preferred over post-docs from well-established labs.

Supported in part by:
Johnson & Johnson
Allergan
Maxia Pharmaceuticals

RECEPTORS AND SIGNAL TRANSDUCTION
July 2-7
Organizers: Jack E. Dixon, Arthur Weiss

3 July. Welcome Remarks and Overview. J.E. Dixon. Receptor Signaling. J. Schlessinger, J. Massague, D. Fruman, G. Yancopoulos, S. Coughlin. Development and Sensory Systems. P. Sternberg, D. Garbers, E. Robey, H. Sun.

4 July. Small GTPases and G-protein Coupled Receptors. A. Hall, D. Bar-Sagi, R.J. Lefkowitz, J. Thorner, C. Der. Intracellular Signaling. S. Taylor, R. Davis, J. Ihle, K.-L. Guan, M. Karin.

5 July. Phosphatases and Other Novel Signaling Strategies. N. Tonks, J. Scott, B. Neel, R. Firtel, J. Noel. Structural Basis for Receptor Signaling. J. Kuriyan, S. Harrison, S.-H. Kim, R. Stroud, E. Goldsmith.

6 July. Cell Death. V. Dixit, N. Thornberry, G. Nuñez, M. Hengartner. Intracellular Signaling and Transcription. S. Emr, E. O'Shea, R. Kaufman, G. Rosenfeld, R. Goodman.

7 July. Emerging Technologies. T. Meyer, P. Andrews, R. Brent, S. Eddy, E. Golemis.

CALCIUM AND CELL FUNCTION
July 9-14
Organizers: Martha C. Nowycky, Tobias Meyer

10 July. Molecular Biology of Calcium Entry. W. Catterall, L. Birnbaumer, C. Montell. Molecular Biology of Intracellullar Stores. B. Ehrlich, P. Worley, C. Franzini-Armstrong.

11 July. Calcium Dynamics. M. Iino, O. Peterson, D. Friel, M. Gallitelli. Decoding Ca Signals. J. Hurley, J. Thorner, T. Meyer. Two brief talks selected from poster presentations.

12 July. Calcium in the Nucleus. H. Bading, T. Means. Calcium and Mitochondria. T. Pozzan, A. Thomas, R. Lewis. Two brief talks selected from poster presentations.

13 July. Calcium and Membrane Traffic. S. Vogel, L. Elferink, G. Augustine, J. Rizo. Plenary Lecture. R. Tsien.

14 July. Multicellular Signaling: Physiology and Pathology. M. Nedergaard, V. Letts.

POST-TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION
July 16-21
Organizers: Robert W. Simons, Stanley N. Cohen

17 July. Key "Players" in the RNA/Protein Interactions of Translation and Decay. J. Hershey, M. Deutscher, S. Kushner, A. Johnson. Enzymes and Multicomponent "Machines" that Process and Degrade RNA. G. Mackie, A. Nicholson, G. Chanfreau, A.J. Carpousis, D. Goldfarb.

18 July. Regulation of mRNA Decay. J. Belasco, B. Simons, A. von Gabain, C. Arraiano, S. Altuvia. Complexities of Translation Initiation. P. Sarnow, M. de Smit, M. Springer, M. Ehrenberg.

19 July. Effects of Translation on mRNA Decay. M. Tuite, R. Gesteland, P. Farabaugh, Y. Nakamura, W. Tate, H. Aiba. Translational Control. M. Grunberg­Manago, A. Hinnebusch, N. Sonenberg, J. McCarthy.

20 July. The Complex Role of 3'­Polyadenylation in Translation and Decay. P. Regnier, M. Wickens, W. Gruissem, S. Cohen. Diverse Means to Couple Transcription, Translation and mRNA Decay I. R. Parker, G. Schuster, S. Lin­Chao, L. Maquat, A. Jacobson.

21 July. Diverse Means to Couple Transcription, Translation and mRNA Decay II. K. McDowall, M. Dreyfus, P. Green, P. Jones.

PROTEIN PHOSPHATASES
July 23-28
Organizers: Anna A. DePaoli-Roach, Benjamin G. Neel

23 July. Opening Lecture: Protein Phosphatases at the Dawn of a New Millennium. E.H. Fischer.

24 July. Genetic Approaches to Determination of Phosphatase Function. T. Mak, J. Sap, M.Tremblay, L. Perkins, K. Tatchell. Structure-function Analysis of Protein Phosphatases. T. Hunter, J.-O. Lee, D. Barford, C. Klee, E.Y.C. Lee.

25 July. Regulation of Protein Phosphatases. J. Avruch, S.-G. Rhee, A. Saltiel, D. Hartshorne, T. Haystead. Targeting Complexes of Protein Phosphatases and/or Kinases. J. Scott, A. DePaoli-Roach, M. Bollen, A. Nairn, B. Wadzinski.

26 July. Phosphatases in Cytoskeletal Function and Cell Adhesion. T. Woodford-Thomas, M. Streuli, N.Tonks, M. Mumby, M. Kasuga, E. Sontag. Phosphatases in Growth Control and Development I. B. Neel, A. Rao, B. Hemmings, N. Rosenthal, T. Mustelin.

27 July. Phosphatases in Growth Control and Development II. K. Siminovitch, J. Maller, T. Cohen, D. Brautigan, R. Honkanen, S. Tamura. Keynote Address: Dissecting Complex Pathways of Signaling Using Transgenic and Knockout Animal Models. C.R. Kahn.

28 July. Phosphatases and Disease. P. Traktman, J. Bliska, D. Virshup, S. Shenolikar, B. Kennedy.

Additional speakers will be selected to represent late-breaking research and to include short talks selected from the abstracts.

Supported in part by:
Eli Lilly
Isis Pharmaceuticals
Abbott Labs.
Sugen, Inc.
Novo Nordisk

RETINAL NEUROBIOLOGY AND VISUAL PROCESSING
July 30-August 4
Organizers: Peter Sterling, Stephen Massey

31 July. Development/Genetics. M. Feller, J. Dowling, H. Baiier, J. Wallman, D. Copenhagen. Outer Retina. E. Strettoi, S. Picaud, Y. Tsukamoto, A. Berntson, D. Dacey.

1 August. Transmitter Release. R. Heidelberger, H. von Gersdorff, D. Zenisek, M. Wilson, M. Higgs. Glia/Transporters. N. Vardi, S. Amara, E. Newman, M. Kamermans.

2 August. Amacrine Modulation. E. Gleason, P. Cook, J. Demb, M. Puopolo, S. Gustincich. Mechanisms of Directional Selectivity. N. Grzywacz, R. Dacheux, R. Taylor, R. Masland.

3 August. Integration at Ganglion Cells. L. Frishman, D. Berson, P. Detwiler, F. Werblin, M. Egelhaaf. Spike Coding. E. Kaplan, M. Meister, P. Reinagel, W. Geisler, K. Boahen.

4 August. Ad Hoc Session. Topics to be announced.

Workshops:
Mouse Retina: Promise and Technical Issues
Mechanisms of Directional Selectivity

LIPID MODIFICATIONS OF PROTEINS
August 6-11
Organizers: Deborah A. Brown, Maurine E. Linder

7 August. Biosynthesis of GPI Anchors. T. Kinoshita, M. Ferguson. Enzymology of Lipid Modifications. P. Casey, J. Gordon, S. Hofmann.

8 August. Therapeutic Applications of Inhibiting Lipidation. R. Bishop, F. Buckner, F. Tamanoi. Trafficking of GPI-anchored Proteins. V. Stevens, M. McConville, G. van der Goot.

9 August. Lipid-modified Proteins in Membrane Domains. A. Magee, D. Brown. Biology of CAAX-processing. M. Philips, J. Buss, S. Young.

10 August. Lipidated Proteins in Signal Transduction. S. Campbell, T. Jones, A. Weiss. Plenary Lecture: Hedgehog Protein-Biogenesis and Signaling. P. Beachy. Cholesterol in Signaling and Membrane Domains. J. Hancock, E. London.

11 August. Lipid Modifications and Protein Targeting. D. Bredt, W. Gruissem, J. Silvius, M. Linder.

Additional platform speakers will be selected from submitted abstracts.

Supported in part by: Schering Plough

MICROBIAL POLYSACCHARIDES OF MEDICAL, AGRICULTURAL, AND INDUSTRIAL IMPORTANCE
August 13-18
Organizers: Joanna B. Goldberg, Arthur O. Tzianabos

13 August. Polysaccharide Genetics in the Era of Genomics. U. Stroeher, J. Yother.

14 August. Polysaccharide Structure and Function.

M. Valvano, B. Gibson, A. Moran. Detection of Enzymes and Structural Modifications in Polysaccharides. J. Lee, S. Valla, S. Trent.

15 August. Polysaccharide Evolution. P. Reeves, C. Whitfield, J.B. Goldberg. Molecular Signaling by Polysaccharides. D. Golenbock, A. Chakrabarty, A. Tzianabos.

16 August. Vaccine Development. G.B. Pier, J. Schreiber, D.L. Kasper. Polysaccharides and Plant Pathogenesis. M. Schell, C. Bender, J. Gonzalez.

17 August. Polysaccharides in the Environment. R. Miller, R.A.J. Warren, E. Rosenberg. Immune Response. F. Stingele, M. Wessels, J. Powell.

18 August. The Role of Microbial Biofilms and Engineering. D.E. Ohman, M. Franklin, M.R. Parsek.

Additional speakers will be selected by the organizers after reviewing abstracts submitted for poster session presentations.

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