Saxtons River
PRELIMINARY PROGRAMS FOR 2000


VIRUS ASSEMBLY
June 10-15
Organizers: Marie Chow, Michael Feiss, John E. Johnson, Margaret Keilian

11 June. Virus Structure. M. Agbandje-McKenna, P. Stewart, M. Nibert, W. Wikoff, F. Rey, Z.H. Zhou. Dynamics of Virus Structures. C. Teschke, J. Conway, R. Hendrix, M. Yeager, P. Tattersall, T. Smith.

12 June. Virus Entry: Receptor and Post-receptor Interactions. A. Helenius, J. Young, R. Doms, D. Bamford, M. Kann, M Malim. Virus Entry: Fusion. J. White, L. Albritton, T. Jardetsky, O. Fuller, D. Eckert.

13 June. Virus Modulation of Cell Biology and Physiology. R. Krug, C. Georgopoulos, G. Parks, P. Ahlquist, D. Rekash. Genome Packaging. L. Black, A. Oppenhiem, S. Weller, A. Schneeman, J. Carrascosa, C. Catalano.

14 June. Virus Capsid Assembly. S. Casjens, W. Sundquist, R. Garcea, M. Estes, T. Dokland, E. Hunter. Virus Exit and Movement. T. Wileman, R. Young, G. Smith, L. Enquist, S. Lazarowitz, R. Webster.

15 June. Implications and Applications to Biotechnology. J. Hogle, M. Whitt, M. Young, C. Patience.


NUCLEIC ACID ENZYMES: STRUCTURES, MECHANISMS AND NOVEL APPLICATIONS
June 17-22
Organizers: Stewart Shuman, Melissa Moore, Martin Gellert

18 June. DNA Repair Enzymes. P. Modrich, J. Petrini, J. Tainer, J. Miller, W. Yang. DNA and RNA Polymerases. D. Price, S. Prakash, T. Ellenberger, B. Landick.

19 June. Transposition and Recombination. M. Belfort, A. Lambowitz, N. Craig, J. Boeke, M. Gellert. DNA and RNA Modification Enzymes. B. Bass, M. Moore, S. Shuman, R. Gumport.

20 June. Helicases and Nucleic Acid-dependent NTPases. D. Wigley, S. Kowalcykowski, B. Schwer, D. Anderson. RNA and DNA Catalysts. D. Bartel, G. Joyce, D. Patel, J. Cate, A. Pyle.

21 June. Cleavage and Degradative Enzymes. D. Tollervey, S. Halford, M. Topal, M. Deutscher. New Applications for Nucleic Acid Enzymes and New Insights from Genomics into the Evolution of Enzyme Systems. D. Gelfand, F. Barany, H. Smith, M. Rosenberg.

22 June. Diseases Related to Nucleic Acid Enzymology. R. Kolodner, N. Ellis, C. McMurray, T. de Lange.

 

Supported in part by:

Roche Molecular Systems

 

Invitrogen


LYMPHOCYTES AND ANTIBODIES
June 24-29
Organizers: Jeffrey Bluestone, Leslie Berg

25 June. Anti-infective Immunity. D. Littman, R. Ahmed, G. Rall, D.L. Sacks, A. Sher. Peripheral Tolerance and Immune Regulation. J. Allison, L. Glimcher, D. Lo, K. Bottomley.

26 June. Lymphocyte Signaling. L. Berg, A. Weiss, R.D. Schreiber, E. Clark, L. Samelson. Apoptosis in the Immune System. C. Thompson, P. Henkart, P. Marrack, S. Korsmeyer.

27 June. Transplantation. J. Bluestone, H. Auchin-closs, L. Matis, K. Wood. Lymphocyte Development. S. Hedrick, M. Bevan, E. Robey, C. Murre, K. Georgopoulos.

28 June. Molecular Structures of Receptor Interactions. P. Bjorkman, I. Wilson, N. Gascoigne, Y. Jones, J.-H. Wang. Anatomy of in vivo Immune Responses. M. Jenkins, J. Cyster, K. Knight, E. Pamer, L. Lefrancois.

29 June. Innate Immunity. L. Lanier, A. Benelac, D. Raulet, M. Colonna, J. Sprent.


LUNG SURFACTANT: CELLULAR AND MOLECULAR BIOLOGY
July 1-6
Organizers: Aron B. Fisher, Jo Rae Wright, Philip Ballard

2 July. Transcriptional Regulation of Surfactant Proteins. J. Whitsett, C. Mendelson, P. Ballard, S.I. Feinstein. Discussants: S. Glasser, R. King. Surfactant Synthesis. R.J. Mason, J. Snyder, L.M. Dobbs. Discussants: E.D. Rannels, J. Lwebuga-Mukasa.

3 July. Surfactant Protein Processing and Function. F. McCormack, T. Weaver, M.F. Beers, S. Hawgood. Discussants: P. Minoo, D. Strayer. Posters A: Transcriptional Regulation, Surfactant Synthesis, and Protein Processing and Function. Surfactant Secretion. H. Shuman, P. Dietl, J. Bhattacharya. Discussants: S. Rooney, A. Chander.

4 July. Extracellular Transformation of Surfactant. J. Zasodzinski, K. Keough, F. Possmayer, N.J. Gross. Discussants: J. Goerke, A. Mautone. Posters B: Secretion, Extracellular Transformations, Endocytosis/Recycling. Endocytosis/Recycling. S. Bates, A.B. Fisher, A.H. Jobe. Discussants: S.L. Young, M. Kresch.

5 July. Host Defense. T. Korfhagen, D.R. Voelker, J.R. Wright, E.C. Crouch. Discussants: J. Fisher, V. Shepherd. Posters C: Host Defense, Manifestations of Disease, Replacement Surfactants. Manifestations of Disease. J. Floros, Y. Kuroki, I. Doyle. Discussants: B. Holm, L. Nogee.

6 July. Replacement Surfactants. R. Notter, J. Johansson, R. Bruni. Discussant: J. Lewis.

Additional platform speakers will be selected to present late breaking work. Speakers to give short talks will be chosen from submitted abstracts.

Supported in part by: Ross Products Div./ Abbott Labs.


SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM
July 8-13
Organizers: Christopher Rudd, Lawrence Samelson

8 July. Keynote Address. R. Davis.

9 July. TcRz/CD3 Signaling. G. Crabtree, D. Cantrell, R. Germain, G. Koretzky. BCR Signaling. J. Cambier, A. Chan, T. Kurosaki.

10 July. Inhibitory Receptors and Signaling. J.P. Kinet, B. Neel, E. Long. Focus on Kinases and Phosphatases. P. Schwartzberg, L. Berg, A. Veillette.

11 July. Adaptors and Accessory Proteins. L. Samelson, C. Rudd, A. Altman. Membrane Microdomains. A. Kupfer, B. Baird. Selected Posters. Six presentations from submitted posters of post-doctoral fellows and students.

12 July. Signaling in Differentiation. H. Von Boehmer, L. Glimcher, A. Singer, R. Flavell. Functional Genomics and Co-receptor Signaling. Speakers to be announced.

13 July. Cytokine Receptor Signaling. W. Leonard, J. O'Shea.

Additional speakers will be selected to present late-breaking work.


MOLECULAR BIOPHYSICS OF CELLULAR MEMBRANES
July 15-20
Organizers: Donald M. Engelman, Stephen H. White

16 July. How are Proteins Inserted into Membranes? A. Johnson, J. Hunt, S. White, D. Mueller. What are the Molecular Events in Membrane Fusion? R. Blumenthal, J. Rothman, B. Lentz.

17 July. What Do We Learn About Membrane Proteins from Genomic and Structural Databases? J.-L. Popot, M. Gerstein, D. Boyd, R. Ranganathan. What are the Structural and Energetic Principles Involved in Helical Membrane Protein Folding? B. de Kruijff, P. Booth, J. Bowie.

18 July. Can Computational Representations of Membrane Systems be Linked to Experimental Observations? R. Pastor, S. Feller, O. Edeholm. How Do Transmembrane Channels Work? E. Perozo, B. Roux, M. Yeager.

19 July. How Does Transmembrane Signalling Work in Terms of Molecular Mechanisms? J. Spudich, F.R. Salemme, W. Brownell. How Does Active Transport Work? E. Landau, S. Subramanian, D. Stock.

20 July. How Can the Re-design of Membrane Proteins be used to Develop Insights Concerning Structure and Function? K. MacKenzie, H. Bayley.

Workshop #1: How Should the NIH Promote Advances in Understanding the Structure and Function of Biological Membranes? D.M. Engelman and representatives from NIH.

Workshop #2: New Approaches to the Study of Biological Membranes: How can we Broaden and Deepen our Database and Understanding? J.-L. Popot.


PROTEIN FOLDING IN THE CELL
July 22-27
Organizers: David A. Agard, Bernd Bukau

23 July. Folding Mechanism and Pathways. S. Radford, C. Bustamonte, A. Sali. Protein Misfolding and Disease. J. Weismann, J. Kelley, H. Sabil, R. Rydel, P. Thomas.

24 July. Folding Mechanism and Catalysis. S. Marqusee, F.-X. Schmid, D. Agard, L. Gierasch. Protein Disaggragation. T. Scheibel, P. Goloubinoff, J. Reinstein, R. Morimoto.

25 July. Mechanism of Chaperone Action I. T. Baldwin, N. Cowan, U. Hartl, A. Horwich. ER Specific Folding and Degradation. J. Brodsky, A. Helenius, H. Pleogh.

26 July. Mechanism of Chaperone Action II. B. Bukau, E. Craig, T. Rappoport, A. Matouschek. Detecting Unfolded Proteins. J. Bardwell, C. Gross, M. Niwa, D. Ron.

27 July. Mechanism of Protein Degradation. S. Jentsch, M. Maurizi, W. Baumeister, D. Finley.

Additional speakers will be selected to present late-breaking work.


INTESTINAL LIPID ABSORPTION, METABOLISM, AND TRANSPORT
July 29-August 3
Organizers: F. Jeffrey Field, Judith Storch

30 July. Sterol Absorption. G. Salen, D. Russell, L. Rudel, R. Farese, P. Tso, T.-Y. Chang. Lipid Metabolism. R. Coleman, C. Mansbach, D. Mangelsdorf, D. Alpers.

31 July. Intestinal Lipid Binding and Transport Proteins. D. Cistola, N. Abumbrad, E. Li, D. Hui, D. Brasaemle. Developmental Regulation of Lipid Metabolism. D. Rubin, D. Black, B. Shneider, V. Yang.

1 August. Bile Formation and Secretion. M. Carey, P. Dawson, L. Bull, R. Oude Elferink, J. Donovan, E. Sehayek. Intestinal Lipases. R. Verger, M. Lowe, F. Carriere, S. Santamarina-Fojo.

2 August. Intestinal Apolipoproteins, Lipoprotein Assembly and Secretion. N. Davidson, S. Young, T. Redgrave, M. Hussain, R. Weinberg. Keynote Address. Moderator. J. Storch. Molecular Genetics of Bile Formation. B. Paigen.

3 August. Lipid Signaling in the Gastrointestinal Tract. E. Dennis, L. Miller, A. Merrill, C. Erlanson-Albertsson, B. Spiegelman.

Supported in part by :

Procter & Gamble
AstraZeneca


CYTOKINES AND LIPID MEDIATORS: BIOSYNTHESIS AND ACTIONS IN HEALTH AND DISEASES
August 5-10
Organizers: Pierre Borgeat, Timothy Williams

6 August. Mechanisms of Lipid Mediator Biosynthesis. C.N. Serhan, G. Folco, O. Rodmark, R.C. Murphy. Lipid Mediator and Chemokine Receptors. G. Craig, K. Metters, M. Rola-Pleszczynski, J. Evans.

7 August. Regulation of the Enzymes of the Lipid Mediator Pathways. P. Borgeat, J. Haeggstrom, T. Bigby, L. Crofford. Lipids and Cytokines in the Regulation of Cell Functions I. S. Marleau, W.C. Smith, S. Nourshargh, W.S. Powell.

8 August. Lipids and Cytokines in the Regulation of Cell Functions II. H. Brady, S. Nigam, M. Coffey, S. McColl. Cytokines and Lipid Mediators in Diseases I. T. Williams, T. Eling, J. Whelan, J. Wallace.

9 August. Cytokines and Lipid Mediators in Diseases II. P. Ponath, C.D. Funk, J.L. Nadler, D.M. Stafforini. Down-regulatory Mechanisms of Inflammation. P.M. Henson, B. Levy, D.C. Zeldin, P. Sirois.

10 August. Chemokines, Lipid Mediators and their Receptors in Host Defense. G. Simmons, D.R. Littman, J. Gosselin, M.L. Peters-Golden


MECHANISMS OF PLANT DEVELOPMENT
August 12-17
Organizers: Vivian Irish, Eric Richards

12 August. Keynote Address: Vertebrate Limb Development. C. Tabin.

13 August. Gametogenesis/Embryogenesis. J. Harada, G. Jurgens, C. Gasser, G. Zinkl. Root Development. F. de Bruijn, B. Scheres.

14 August. Shoot Development: Meristems. K. Berton, S. Clark, S. Hake, D. Weigel. Shoot Development: Morphogenesis. S. Poethig, J. Langdale, D. Marks, C. Kuhlemeier.

15 August. Evolution and Development. V. Irish, J. Doebley, M. Donoghue, D. Baum, R. Coen. Signaling. O. Leyser, J. Ecker, J. Li.

16 August. Responses to the Environment. M. Liscum, J. Chory, S. Kay. Epigenetics/Chromatin. J. Finnegan, U. Grossniklaus, E. Richards.

17 August. Emerging Technologies. R. Martienssen.


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