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Scientists Create Britain's First Stem
Cell Line
LONDON (Reuters) - Scientists said
on Wednesday they had created Britain's first human embryonic
stem cell line, clearing the way for more research into diseases
including diabetes and Parkinson's.
The team, at King's College London, said the new line -- a string
of many identical cells -- would be deposited in the Medical Research
Council's $4.2 million stem cell bank, which was launched
last year.
Stem cells hold the promise of treating a range of medical conditions
but their use is controversial because although they are found
in adult tissue, the most flexible stem cells come from early
embryos.
In this case, the researchers said they obtained three stem
cell lines from 58 embryos. Two cell lines perished but the remaining
one had now been growing for many months.
"We are very excited about this development," said Dr Stephen
Minger, one of the leaders of the team whose work was published
in Reproductive BioMedicine Online.
"Human embryonic stem cells are found in the earliest stages
of development and are capable of giving rise to all the different
types of cell in the body. This means their possible therapeutic
uses are almost endless."
Minger told Reuters the researchers were particularly interested
in research aimed at generating new cells for transplantation
in diabetes and Parkinson's disease (news
- web
sites), and possibly also for patients with heart disorders.
Traditionally, stem cell lines have been created with great
difficulty using cells from embryos surplus to IVF, which are
often of poor quality.
But in this case, high-quality embryos were donated by women
undergoing pre-implantation genetic diagnosis because they were
known to be at risk of passing on serious genetic disorders if
they had children.
Only embryos unaffected by these disorders were replaced into
the women. Cells from the remaining embryos, which were unsuitable
for replacement and would normally have perished, were used to
generate the stem cell lines.
The Kings College team was one of the first two laboratories
in Britain to be granted a license by the Human Fertilization
and Embryology Authority to generate human embryonic stem cells.
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