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Challenges in Pediatric Drug Delivery

• Tight junction modulation and its relationship to drug delivery
• The evolution of legislation to regulate pediatric clinical trials
• Pharmacological research in pediatrics
• Novel approaches to pediatric vaccine delivery
• Needle-free vaccine delivery
• Mucosal delivery of vaccine antigens and its advantages in pediatrics
• Clinical trials in pediatrics
• Challenges in pediatric drug delivery

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Fluorescence imaging

• Use of fluorescence imaging to investigate the structure and function of intestinal M cells
• the evolving role of fluorescence imaging in drug delivery research
• Studying biophysical barriers to DNA delivery by advanced light microscopy
• Real-time multiple-particle tracking
• Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy
• Intracellular trafficking pathways and drug delivery
• Imaging living central neurones using viral gene transfer
• Fluorescence techniques for drug delivery research
• Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate
• Fluorescence correlation spectroscopy of molecular motions and kinetics
• Applications of imaging techniques to studies of epithelial tight junctions
• Advances in fluorescence imaging
• Advanced microscopy solutions for monitoring the kinetics and dynamics of drug-DNA targeting in living cells

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Drug delivery intestine

• Rafts and related glycosphingolipid-enriched microdomains in the intestinal epithelium-bacterial targets linked to nutrient absorption
• Probiotics in inflammatory bowel disease?atherapeutic rationale and role
• Poliovirus vaccine strains as mucosal vaccine vectors and their potential use to develop an AIDS vaccine
• Pathogen invasion across intestine-mechanisms and potential exploitation
• Microbes and their products?aphysiological effects upon mammalian mucosa
• Mechanism of intestinal entry of infectious prion protein in the pathogenesis of variant Creutzfeldt¨CJakob disease
• Intestinal epithelial tight junctions as targets for enteric bacteria-derived toxins
• ICAM-1-targeted docking for exogenous as well as endogenous ligands
• Helminths at mucosal barriers?ainteraction with the immune system
• Dendritic cells and oral transmission of prion diseases
• Apical membrane receptors on intestinal M cells-potential targets for vaccine delivery

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pharmacogenomics

• Pharmacogenomics
• Trends in pharmacogenomics of drugs used in the treatment of asthma
• Trends in pharmacogenomics of drugs acting on hypertension
• Pharmacogenetics of neoplastic diseases
• Pharmacogenetics of antipsychotic-induced weight gain
• Pharmacogenetics and pharmacogenomics
• Ethical considerations on pharmacogenomics
• DNA microarrays and pharmacogenomics
• Adverse drug reactions-role of pharmacogenomics
• Protecting communities in pharmacogenetic and pharmacogenomic research
• Promoting comparative molecular studies in environmental health research
• PharmGKB-the pharmacogenetics and pharmacogenomics knowledge base
• Multilocus effects of the renin-angiotensin-aldosterone system genes on blood pressure
• Making sense of microarray data to classify cancer
• Pharmacogenetics and psychopharmacology

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Pharmaceutical solid polymorphism

• Pharmaceutical solid polymorphism
• Pharmaceutical solid polymorphism in drug development and regulation
• General principles of pharmaceutical solid polymorphism
• The computational prediction of pharmaceutical crystal structures and polymorphism
• Regulatory considerations of pharmaceutical solid polymorphism in Abbreviated New Drug Applications
• Polymorphism in generic drug product development
• Phase transformation considerations during process development and manufacture of solid oral dosage forms
• Impact of solid state properties on developability assessment of drug candidates
• High-throughput crystallization-polymorphs, salts, co-crystals and solvates of pharmaceutical solids
• General principles of pharmaceutical solid polymorphism
• Drug polymorphism and dosage form design
• Applications of process analytical technology to crystallization processes
• A timely re-examination of drug polymorphism in pharmaceutical development and regulation

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Proteasome Inhibitors

• Proteasome Inhibitors As Therapeutic Agents
• P27kip1 In Proteasome Inhibitor-Induced Apoptosis
• Proteasome Inhibitors As New Anticancer Drugs
• Proteasome Inhibition-Rationale For The Treatment Of Solid Tumors With The Proteasome Inhibitor Bortezomib
• Proteasome Inhibition-Proteasome Inhibitors In Solid Tumors
• Proteasome Inhibition-Proteasome Inhibitors In Hematologic Malignancies
• Chemical biology-drug-Preclinical and clinical evaluation of proteasome inhibitor PS-341 for the treatment of cancer
• Development of the Proteasome Inhibitor PS-341
• Cardioprotection A proteasome inhibitor confers cardioprotection
• Development of the Proteasome Inhibitor PS-341
• proteasome pathway and proteasome inhibitors
• The ubiquitin-proteasome pathway and proteasome inhibitors
• Proteasome inhibitors- from research tools to drug candidates
• Proteasome Inhibitor PS519 Reduces Infarction and Attenuates Leukocyte Infiltration in a Rat Model of Focal Cerebral Ischemia
• Postischemic (6-Hour) Treatment With Recombinant Human Tissue Plasminogen Activator and Proteasome Inhibitor PS-519 Reduces Infarction in a Rat Model of Embolic Focal Cerebral Ischemia

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Nuclear Transport

• Virus Nuclear Import
  
• Role Of The Cytoskeleton In Nuclear Import
  
• Nuclear Transport-An Emerging Opportunity For Drug Targeting
  
• Mechanisms Of Nuclear Transport And Interventions
  
• Emerging Significance Of Plasmid Dna Nuclear Import In Gene Therapy
  
• Drug-Nuclear Transport-
  
• Molecular Mechanisms That Regulate Transcription Factor Localization Suggest New Targets For Drug Development
  

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Calcium antagonists

• Calcium antagonists
• Calcium antagonists and endothelial function
• Dihydropyridines and the treatment of hypertension
• Hypertension in the elderly and calcium antagonists
• L-and T-type calcium channel blockade – the efficacy of the calcium channel antagonist mibefradil
• Lercanidipine, a new third generation Ca-antagonist in the treatment of hypertension
• The rationale of using calcium antagonists in the treatment of ischaemic heart disease
• Calcium Antagonist Treatment by Lercanidipine Prevents Hyperpolarization in Essential Hypertension
• Effects of the Selective Aldosterone Blocker Eplerenone Versus the Calcium Antagonist Amlodipine
• Evidence-Based-ACE inhibitors, calcium antagonists, and more intensive blood pressure lowering strategies reduce cardiovascular events
• Evidence-Based-calcium antagonists lead to a higher risk for myocardial infarction, congestive heart failure, and major cardiovascular events

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Drug prediction－computation method

• Comparative modelling of cytochromes P450
• Computer systems for the prediction of toxicity
• Computer systems for the prediction of xenobiotic metabolism
• Modeling of active transport systems
• Pharmacophore modeling of cytochromes P450
• Physiologically-based pharmacokinetic simulation modelling
• Prediction of drug solubility from structure
• Prediction of drug-likeness
• Prediction of intestinal permeability
• prediction of the blood-brain distribution
• Progress in understanding the structure-activity relationships of P-glycoprotein
• Computational methods-for the prediction of ADME and Toxicity
• Comparative modelling of cytochromes P450
• Computational approaches to the prediction of the blood?§Cbrain distribution
• Computer systems for the prediction of toxicity
• Computer systems for the prediction of xenobiotic metabolism
• Modeling of active transport systems
• Pharmacophore modeling of cytochromes P450
• Physiologically-based pharmacokinetic simulation modelling
• Prediction of drug solubility from structure
• Prediction of drug-likeness
• Prediction of intestinal permeability
• Progress in understanding the structure?§Cactivity relationships of P-glycoprotein

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Drug Delivery

• Anticancer drug delivery systems
• ATTEMPTS-a heparin-protamine-based delivery system for enzyme drugs
• Biodegradable pH-sensitive surfactants (BPS) in liposome-mediated nucleic acid cellular uptake and distribution
• Biomolecule-sensitive hydrogels
• BUILDING DRUG DELIVERY INTO TISSUE ENGINEERING
• Clinical aspects of drug delivery to tumors
• Colon-specific drug delivery
• Design and evaluation of a mucoadhesive therapeutic agent delivery system
• Design and gene delivery activity of modified polyethylenimines
• Design of biodegradable particles for protein delivery
• Design of novel bioconjugates for targeted drug delivery
• Designing peptide-based scaffolds as drug delivery vehicles
• Development of gene drug delivery systems based on pharmacokinetic studies
• Device-directed therapeutic drug delivery systems
• Engineering endogenous inflammatory cells as delivery vehicles
• Environment-sensitive hydrogels for drug delivery
• Enzyme-activated targeting of liposomes
• Formulation aspects in the development of osmotically controlled oral drug delivery systems
• Hydrogels for biomedical applications
• In situ forming degradable networks and their application in tissue engineering and drug delivery
• Lactamases-which ones are clinically important
• Lipid formulations for oral administration of drugs
• Liposomal formulations of anticancer drugs
• Loading into and electro-stimulated release of peptides and proteins from chondroitin 4-sulphate hydrogels
• Membrane transporters
• Microdialysis for the evaluation of penetration through the human skin barrier_a promising tool for future research
• Modulated insulin delivery from glucose-sensitive hydrogel dosage forms
• Molecular imprinting within hydrogels
• Multipulse drug permeation across a membrane driven by a chemical pH-oscillator
• Nanosized cationic hydrogels for drug delivery
• Novel crosslinking methods to design hydrogels
• Novel mechanisms and devices to enable successful transdermal drug delivery
• pH-Sensitive polymers that enhance intracellular drug delivery
• Protein delivery using VP22
• Pulsatile drug release control using hydrogels
• Rationale and applications of lipids as prodrug carriers
• Recent patents in drug delivery
• Receptor-mediated delivery
• Submicron emulsions as drug carriers
• Surface modification of liposomes for selective cell targeting in cardiovascular drug delivery
• Targeted PEG-based bioconjugates enhance the cellular uptake and transport of a HIV-1 TAT nonapeptide
• Thermosensitive polymer-modified liposomes
• Thermosensitive sol?§Cgel reversible hydrogels
• Transport of drugs from the nasal cavity to the central nervous system
• Treating atherosclerosis-local drug delivery from laboratory studies to clinical trials
• Water-activated, pH-controlled patch in transdermal administration of timolol-I. Preclinical tests
• Water-activated, pH-controlled patch in transdermal administration of timolol-II. Drug absorption and skin
• drug-delivery-Phototriggering of liposomal drug delivery systems
• Development of Delivery Agents that Facilitate the Oral Absorption of Macromolecular Drugs
• Targeting drugs to the brain by redox chemical delivery systems

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药物设计与基因治疗

• From Drug Design to Gene Therapy
• From Drug Design to Gene TherapyAAV-Mediated Gene Transfer for Hemophilia
• From Drug Design to Gene TherapyBone Marrow as a Source of Endothelial Cells for Natural and Iatrogenic Vascular Repair
• From Drug Design to Gene TherapyGene Therapy- A Brief Overview of the Past, Present, and Future
• From Drug Design to Gene TherapyGene Therapy for Cardiovascular Disorders- Is There a Future
• From Drug Design to Gene TherapyMedicinals for the Millennia- The Historical Record
• From Drug Design to Gene TherapyRegulated Gene Expression in Gene Therapy
• From Drug Design to Gene TherapyRetroviral Approaches to Gene Therapy of Cystic Fibrosis

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组合化学
　

• Combinatorial chemistry – The emperor's new clothes
• Combinatorial chemistry and biomedical polymer development
• Combinatorial chemistry in anti-infectives research
• Combinatorial chemistry-20 years
• Chemical information management in drug discovery- optimizing the computational and combinatorial chemistry interfaces
• Dynamic combinatorial chemistry
• Immobilized catalysts in combinatorial chemistry
• Nanotiterplates for combinatorial chemistry
• Statistical design and application to combinatorial chemistry

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Radiation Therapy
　

• Chelated Metal Ions for Therapeutic and Diagnostic Applications
• In Vivo Protection Against Gamma-Irradiation with 5-Androstenediol
• Raf-1 Protein Kinase, Signal Transduction, and Targeted Intervention of Radiation Response
• Radiation Therapy Symposium- Introduction

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Drug and mitochondria
　

• Pharmacology of Nucleoside and Nucleotide Reverse Transcriptase Inhibitor-Induced Mitochondrial Toxicity
• An antigenomic strategy for treating heteroplasmic mtDNA disorders
• Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems
• Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
• Drug and DNA delivery to mitochondria
• Gene therapy by mitochondrial transfer
• Human mitochondrial DNA diseases
• Mitochondria as subcellular targets for clinically useful anthracyclines
• Mitochondria as target for antiischemic drugs
• Mitochondria make a come back
• Mitochondria-based photodynamic anti-cancer therapy
• Mitochondrial contributions to cancer cell physiology
• Mitochondrial DNA metabolism targeting drugs
• RNA delivery into mitochondria
• Targeting large molecules to mitochondria
• Drugs on Target

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Drug and DNA delivery to mitochondria
　

• Drug and DNA delivery to mitochondria
• Cationic bolasomes with delocalized charge centers as mitochondria-specific DNA delivery systems
• Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
• Gene therapy by mitochondrial transfer
• Human mitochondrial DNA diseases
• Mitochondria as subcellular targets for clinically useful anthracyclines
• Drug and DNA delivery to mitochondria Mitochondria as target for antiischemic drugs
• Mitochondria make a come back
• Mitochondria-based photodynamic anti-cancer therapy
• Mitochondrial contributions to cancer cell physiology
• Mitochondrial DNA metabolism targeting drugs
• RNA delivery into mitochondria
• Targeting large molecules to mitochondria
• Drug and DNA delivery to mitochondria

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β-blockers

　
• β-blockers
• β-blockers-Clinical trials of β-blockers in heart failure
• β-blockers-Current utilization trends for β-blockers in cardiovascular disease
• β-blockers-Optimizing the use of β-blockers in the effective treatment and management of heart failure

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