Computational proteomics

• Algorithms and tools for analysis and management of mass spectrometry data
• Approaches to dimensionality reduction in proteomic biomarker studies
• Classification of mass-spectrometric data in clinical proteomics
• Computational methods for the comparative quantification of proteins in label-free LCn-MS experiments
• Information quality in proteomics
• Machine learning methods for predictive proteomics
• management and analysis of proteomics data
• The HUPO proteomics standards initiative—easing communication and minimizing data loss
• Methods, algorithms and tools in computational proteomics
• Computational Proteomics Analysis System

back

Protein technology

• Applications of antibody array platforms
• Cell-free expression systems for eukaryotic protein production
• Challenges in therapeutic glycoprotein production
• Cloning technologies for protein expression and purification
• DNA microarray technologies for measuring protein–DNA interactions
• Enhancement of soluble protein expression through the use of fusion tags
• Finding one of a kind-advances in single-protein production
• Folding aggregated proteins into functionally active forms
• Looking towards label-free biomolecular interaction analysis in a high-throughput format
• Mammalian cell factories for efficient and stable protein expression
• Mapping protein–protein interactions by mass spectrometry
• Molecular imaging of thin mammalian tissue sections by mass spectrometry
• Phosphoproteomic approaches to elucidate cellular signaling networks
• Protein technologies
• Understanding recombinant expression of membrane proteins
• Yeast two-hybrid contributions to interactome mapping

back

Human Peroxidases

• Chemistry and biology of human peroxidases
• Structural and functional aspects of thyroid peroxidase
• Role of eosinophil peroxidase in host defense and disease pathology
• Origin, structure, and biological activities of peroxidases in human saliva
• Myeloperoxidase-mediated oxidation of high-density lipoproteins
• Biosynthesis, processing, and sorting of human myeloperoxidase
• Active site structure and catalytic mechanisms of human peroxidases

back

PROTEIN interaction

• Use of 4-Thiouridine and 4-Thiothymidine in Studies on Pyrimidine Nucleoside Phosphorylases
• Type IIE and IIF Restriction Endonucleases Interacting with Two Recognition Sites on DNA
• Specificity of DNA–Protein Interactions within Transcription Complexes
• RNA Synthesis by T7 RNA Polymerase Supported Primer Extension
• Poly(ADP-ribose) polymerase-1-A Regulator of Protein–Nucleic Acid Interactions
• ole of Weak Specific and Nonspecific Interactions in Enzymatic Recognition and Conversion of Long DNAs
• Nucleotide-Dependent Degradation of Nucleic Acids by DNA and RNA Polymerases
• New Noncleavable Analogs of 8-Oxoguanine-DNA Glycosylase Substrates
• Molecular Enzymology of Phage T4 Dam DNA Methyltransferase
• Interactions of HIV-1 DNA Heterocyclic Bases with Viral Integrase
• Identification of RNA-Recognizing Modules on the Surface of Ribosomal Proteins
• Antirestriction Activity of ArdA Encoded by the IncI1 Transmissive Plasmid R64
• Antimutagenic Role of Autonomous 3′ → 5′-Exonucleases
• DNA–PROTEIN interaction

back

Protein Synthesis in Health and Disease

• Translational control in virus-infected cells
• The role of the AU-rich elements of mRNAs in controlling translation
• The implications of structured 5′ untranslated regions on translation and disease
• Role of amino acids in the translational control of protein synthesis in mammals
• mTOR, translational control and human disease
• Mechanisms of translational control by the 3′ UTR in development and differentiation
• eIF2 and the control of cell physiology
• Protein Synthesis in Health and Disease

back

Protein Phosphatases

• Tyrosine phosphatases in cancer
• The dual-specific protein tyrosine phosphatase family
• The CD45 phosphotyrosine phosphatase
• Structure and function of the T-cell protein tyrosine phosphatase
• Shp-2 tyrosine phosphatase
• SHP-1 twelve years on-structure, ligands, substrates and biological roles
• Roles of mammalian protein phosphatase 2C family members in the regulation of cellular functions
• Receptor protein tyrosine phosphatases
• Protein tyrosine phosphatase-based therapeutics
• Protein phosphatase 2A
• Protein phosphatase 1
• Protein histidine phosphatases in signal transduction and metabolism
• PP5-the TPR phosphatase
• Functional proteomics in phosphatase research
• Calcineurin-Roles of the Ca 2+-calmodulindependent protein phosphatase
• Anchoring of protein kinase and phosphatase signaling units
• 5 Roles of mammalian protein phosphatase 2C
• Protein Phosphatases

back

Serum And Glucocorticoid Inducible Kinase

• Stimulus-Dependent Regulation Of Serum And Glucocorticoid Inducible Protein Kinase (Sgk) Transcription, Subcellular Localization And Enzymatic Activity
• Sgk1-Aldosterone-Induced Relay Of Na+ Transport Regulation In Distal Kidney Nephron Cells
• Regulation Of Channels By The Serum And Glucocorticoid-Inducible Kinase Biochem-Atm-A Central Controller Of Cellular Responses To Dna Damage
• Cell-Sgk1 Regulation Of Epithelial Sodium Transport

back

Enzyme Behaviour

• It Can Be-Complicated Life Being An Enzyme
• Implications Of Enzyme Kinetics
• Human Porphobilinogen Deaminase Mutations In The Investigation Of The Mechanism Of Dipyrromethane Cofactor
• How To Tell The Time-The Regulation Of Phosphoenolpyruvate Carboxylase In Crassulacean Acid Metabolism
• Exploring The Structure And Function Of Zinc Metallopeptidases-Old Enzymes And New Discoveries
• Clathrin-Coated Vesicle Formation--Paradigm For Coated-Vesicle Formation

back

P-Glycoprotein

• A Role For P-Glycoprotein In Regulating Cell Growth And Survival
• And Alloimmune T-Cell Activation
• Development, Function And Maintenance Of T Lymphocyte Populations In P-Glycoprotein-Deficient Mice
• Expression And Function In T-Lymphocytes
• P-Glycoprotein (P-Gp) Function In T Cells
• P-Glycoprotein Expression In The Cells Of The Immune System During Aging
• biochem-P-glycoprotein Catalytic Mechanism
• Multidrug resistance 1 gene (P-glycoprotein 170)- an important determinant in gastrointestinal disease

back

Protein Kinase C Isotypes

• Activation Mechanisms of Protein Kinase C-Maturation, Catalytic Activation
• Protein Kinase C Isotypes-and Their Specific Functions-Prologue
• Discovery and Prospect of Protein Kinase C Research
• Protein Kinase C (PKC) Isoforms in Drosophila
• Protein Kinase C Isotypes in C. elegans
• Protein Kinase C&eta-(PKC&eta)
• Protein Kinase C&eta-Its Involvement in Keratinocyte Differentiation
• Protein Kinase Ca (PKCa)-Regulation and Biological Function
• Protein Kinase Cb (PKCb)-Normal Functions and Diseases
• Protein Kinase Cd (PKCd)-Activation Mechanisms and Functions
• Protein Kinase C-e (PKC-e)
• Protein Kinase Cg (PKCg)-Function of Neuron Specific Isotype
• Protein Kinase Cl-i (PKCl-i)-A PKC Isotype Essential
• Protein Kinase Cq (PKCq)-A Key Enzyme in T Cell Life and Death
• Protein Kinase Cz (PKCz)-Activation Mechanisms and Cellular Functions
• The Structure and Function of PKN
• Yeast Protein Kinase C

back

S100 protein

• S100 protein
• Differential expression of S100 proteins in the developing human hippocampus and temporal cortex
• Frog p26olf, a molecule with two S100-like regions in a single peptide
• Immunohistochemical localization of S100-like protein in non-mammalian kidney
• Intracellular and extracellular roles of S100 proteins
• Molecular mechanisms of S100-target protein interactions
• Monitoring of S100 homodimerization and heterodimeric interactions by the yeast two-hybrid system
• Multiple structural states of S100A12-A key to its functional diversity
• Myeloid representatives of the S100 protein family as prominent players in innate immunity
• renal cells-Calcium-and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments
• S-100 proteins in the human peripheral nervous system
• S100B in brain damage and neurodegeneration

back

Hypoxia-inducible Transcription Factor

• Molecular Mechanisms of Pre-T Cell Receptor-induced Survival
• HIF-1 and tumor progression-pathophysiology and therapeutics
• Two sequence motifs from HIF-1 bind to the DNA-binding site of p53
• Role of nitric oxide in the regulation of HIF-1 expression during hypoxia
• Hypoxia and HIF-1 Stability
• The essential role of Cited2, a negative regulator for HIF-1, in heart development
• Two HIFs may be better than one
• Cell signaling, transcription and translation as therapeutic targets-Is HIF-1 a pro-or an anti-apoptotic protein
• HIF-1-induced erythropoietin in the hypoxic retinal degeneration
• Intramyocardial injection of naked DNA encoding HIF-1α-VP16 hybrid to enhance angiogenesis in an acute myocardial infarction
• HIF-1 and tumor progression-pathophysiology and therapeutics
• Structural basis for Hif-1-CBP recognition in the cellular hypoxic response
• Early Expression of Myocardial HIF-1 in Response to Mechanical Stresses -Regulation by Stretch-Activated Channels and the Phosphatidylinositol 3-Kinase Signaling Pathway
• Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1
• Asparagine Hydroxylation of the HIF Transactivation Domain-A Hypoxic Switch
• HIF-1 gene therapy
• HIF-1-mediator of physiological and pathophysiological responses to hypoxia
• Transcription factors p53 and HIF-1 as targets of nitric oxide
• HIF-1 and human disease-one highly involved factor
• HIF-1, O2, and the 3 PHDs-How Animal Cells Signal Hypoxia to the Nucleus
• Induction of HIF-1 in response to hypoxia is instantaneous
• HIF-1 and mechanisms of hypoxia sensing
• HIF-1 and mechanisms of hypoxia sensing
• Targeting tumors through the HIF system
• RECODE- a database of frameshifting, bypassing and codon redefinition utilized for gene expression
• Fh-Souassi: a founder frameshift mutation in exon 10 of the LDL-receptor gene, associated with a mild phenotype in Tunisian families
• Sonographic Monitoring of Midline Shift in Space-Occupying Stroke
• Targeting tumors through the HIF system
• HIF-1- mediator of physiological and pathophysiological responses to hypoxia
• Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1-VP16 Hybrid Transcription Factor
• HIF-1 and human disease- one highly involved factor
• AG-HIF-1- Using Two Hands to Flip the Angiogenic Switch
• Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1-VP16 Hybrid Transcription Factor
• HIF-1 and human disease
• Antioxidant-Pro-oxidant Equilibrium Regulates HIF-1 and NF-B Redox Sensitivity
• Hypertension -- Intengan and Schiffrin 35 (6) 1221
• Molecular cloning of cDNAs encoding hypoxia-inducible factor (HIF)-1 and -2 of bovine arterial endothelial cells
• HIF

back

Protein Systhesis

• Oxidant Stress Stimulates Phosphorylation of eIF4E without an Effect on Global Protein Synthesis in Smooth Muscle Cells
• Focal Adhesion Kinase Is Involved in Angiotensin II CMediated Protein Synthesis in Cultured Vascular Smooth Muscle Cells
• Induction of cell death in Arabidopsis by superoxide in combination with salicylic acid or with protein synthesis inhibitors
• Alcohol myopathy: impairment of protein synthesis and translation initiation
• Specific Stimulation of Protein Synthesis by Nitric Oxide Synthase Inhibition -Role of Extracellular Signal–Regulated Kinases 1-2
• Molecular mechanisms for a activity-regulated protein synthesis in the -synapto-dendritic compartment
• Non-cardiac nucleic acid composition and protein synthesis rates in hypertension: studies on the spontaneously hypertensive rat (SHR) model
• Oxidant Stress Stimulates Phosphorylation of eIF4E without an Effect on Global Protein Synthesis in Smooth Muscle Cells
• Protein synthesis in axons and terminals
• Initiation of Protein Synthesis from the A Site of the Ribosome
• Chemical protein synthesis
• Protein synthesis in axons and terminals
• structure and function of initiation factors in eukaryotic protein synthesis
• A post-genomic challenge- learning to read patterns of protein synthesis
• Protein synthesis in axons and terminals
• search of molecular memory- experience-driven protein synthesis
• protein synthesis-A decade of progress in understanding the structural basis of protein synthesis
• A post-genomic challenge- learning to read patterns of protein synthesis
• protein synthesis
• protein synthesize in vivo
• ns-PROTEIN SYNTHESIS AT SYNAPTIC SITES ON DENDRITES
• Molecular Kinesis in Cellular Function and Plasticity-Synaptic regulation of protein synthesis and the fragile X protein
• Cell proliferation and protein synthesis as initial factors in determination of axial polarity
• Plasticity in Skeletal, Cardiac, and Smooth Muscle- IGF-I antibody prevents increases in protein synthesis
• physiol-Plasticity in Skeletal, Cardiac, and Smooth Muscle-IGF-I antibody prevents increases in protein synthesis in epitrochlearis muscles
• PROTEIN SYNTHESIS AT SYNAPTIC SITES ON DENDRITES
• Renal Disease-Can We Increase Protein Synthesis by Anabolic Factors
• Specific Stimulation of Protein Synthesis by Nitric Oxide Synthase Inhibition-Role of Extracellular Signal?§CRegulated Kinases 1-2
• The transorientation hypothesis for codon recognition during protein synthesis
• A tripeptide discriminator for stop codon recognition
• Cysteinyl-tRNA formation and prolyl-tRNA synthetase
• Elongation factor-2 kinase and its newly discovered relatives
• Ribosomal RNA pseudouridines and pseudouridine synthases
• Ribosome as a molecular machine
• Translocation of tRNA during protein synthesis
back

Protein Design

• Protein Design:Introduction
• De Novo Design of Proteins-What Are the Rules
• De Novo Proteins from Combinatorial Libraries
• Design of Folded Peptides
• Designing Protein Energy Landscapes
• Engineering Novel Metalloproteins
• Enzyme Redesign
• Generation of New Enzymes via Covalent Modification of Existing Proteins
• Peptide-Based Heme-Protein Models
• Peptides-From Structure to Function
• Protein Design and Phage Display

back

Protein Domains

• Calmodulin signaling via the IQ motif
• Can we infer peptide recognition specificity mediated by SH3 domains
• EVH1 domains-structure, function and interactions
• How do 14-3-3 proteins work-Gatekeeper phosphorylation
• Interaction domains-from simple binding events to complex cellular behavior
• MINT-a Molecular INTeraction database
• Normalization of nomenclature for peptide motifs as ligands of modular protein domains
• Pleckstrin homology domains and the cytoskeleton
• Protein domain analysis in the era of complete genomes
• PTB or not PTB-that is the question
• Signaling to the Rho GTPases-networking with the DH domain
• The ENTH domain
• The Eps15 homology (EH) domain
• The FHA domain
• The paxillin LD motifs
• The phosphatidylinositol 3-phosphate-binding FYVE finger
• The spectrin repeat-a structural platform for cytoskeletal protein assemblies
• VHS domain-a longshoreman of vesicle lines
• WH2 domain-a small, versatile adapter for actin monomers
• WW and SH3 domains, two different scaffolds to recognize proline-rich ligands

back

蛋白质组

• Alternative splicing and functional genemics
• Genomics & proteomics
• Large-scale analysis of the yeast proteome by multidimensional protein identification technology
• Piecing together the significance of splicing
• Recent patents in proteomics
• The end of the beginning for genomic medicine
• 3D modelling of gene expression patterns
• PROTEIN INTERACTION MAPS FOR MODEL ORGANISMS
• Relationship between Whole Proteome Aminoacid Composition and Static DNA Curvature
• The past, present and future of molecular computing
• A Proteome Analysis of the Cadmium Response in Saccharomyces cerevisiae
• Molecular Cloning and Characterization of Endosialin, a C-type Lectin-like Cell Surface Receptor of Tumor Endothelium
• New Ways of Initiating Translation in Eukaryotes
• Breaking open a protein barrel
• Mechanisms of protein folding
• Protein microarrays- prospects and problems
• Proteomics and genomics A selection of World Wide Web sites
• proteomr-Proteinˉnucleic acid interactions
• Are you getting enough protein
• Protein microarrays
• Functional proteins from a random-sequence library
• Imaging mass spectrometry-A new technology for the analysis of protein expression
• Insights into a plasma membrane signature
• Mutation processes at the protein level
• Functional proteomic analysis of PKC signaling complexes in the normal heart and during cardioprotection
• Cardiovascular Proteomics
• Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
• Proteome Sciences - Links
• Proteome Sciences - The Proteomic Technology
• Proteome Sciences - web
• Search Results for proteome and 2001
• Making predictions about the proteome
• PROTEOME SCIENCES PLC SUCCESSFULLY COMPLETES FUNDING AND EXTENDS ITS RESEARCH AGREEMENT WITH THE CLORE LABORATORY
• The age of proteomics arrives
• Proteomics 2001
• Proteomics in Genomeland
• Proteome analysis
• Proteome analysis-2
• Measuring gene expression by quantitative proteome analysis
• Origin of multicellular eukaryotes – insights from proteome comparisons
• The nature of the universal ancestor and the evolution of the proteome
• their post-translational modifications in proteome analysis
• 2D or not 2D
• A Biological Atlas of Functional Maps
• A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
• A functional genomics strategy that to reveal the phenotype of silent mutations
• A genomic perspective on plant transcription factors
• A network of protein-protein interactions in yeast
• A post-genomic challenge- learning to read patterns of protein synthesis
• A post-genomic perspective
• A yeast prion provides a mechanism for genetic variation and phenotypic diversity
• Advances in 2D gel techniques
• Advances in mass spectrometry for proteome analysis
• Alternative splicing- increasing diversity in the proteomic world
• Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
• Analysis of the microbial proteome
• Antibodies in diagnostics – from immunoassays to protein chips
• Applied genomics- integration of the technology within pharmaceutical research and development
• Caution marks prospects for exploiting the genome
• Characterisation of bacterial proteomes by two-dimensional electrophoresis
• Chemical biology beyond binary codes
• Chemical strategies for the global analysis of protein function
• Computational methods for protein function analysis
• Convergent evolution with combinatorial peptides
• Current status and perspectives of proteomics in aging research
• DNA microarrays for expression profiling
• Domain repertoires as a tool to derive protein recognition rules
• Four years of post-genomic life with 6000 yeast genes
• From the analysis of protein complexes to wide linkage maps
• Functional annotation of a full-length mouse cDNA collection
• Functional genomic analysis of C
• Functional genomics by mass spectrometry
• Gene expression data analysis
• Gene expression profiling
• generic protein purification method for protein complex characterization and proteome exploration
• Genome-wide protein interaction maps using two-hybrid systems
• Genomic analysis of biochemical function
• Genomics and medicine
• H
• Identifying the  software tools
• Integrated studies on plant biology using multiparallel techniques
• Integration of genome data and protein structures
• Is the development of a new tuberculosis vaccine possible
• Large-scale functional analysis using peptide or protein arrays
• Lessons from metabolic engineering for functional genomics and drug discovery
• Microarrays and cell cycle transcription in yeast
• Molecular evidence for an ancient duplication of the entire yeast genome
• Molecular markers of tumor initiation and progression
• new insights from complete genome analysis
• New methods of proteome analysis
• Novel method for the proteomic investigation of a dairy-associated Bacillus cereus biofilm
• Peptide inhibitors expressed in vivo
• Pharmacogenetics and adverse drug reactions
• PPMdb-proteome database
• Probing proteomes--seeing the whole picture
• Profiling the specific reactivity of the proteome with non-directed activity-based probes
• Protein arrays and microarrays
• Protein biochips for differential profiling
• Protein complexes and analysis of their assembly by mass spectrometry
• Protein structure prediction
• Proteins emerge from disarray
• Proteins, peptides, proteomics
• Recent advances in large-scale transposon mutagenesis
• Selection and application of peptide-binding peptides
• sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
• Sequences and topology- Genome and proteome informatics
• Spliceosome-mediated RNA trans-splicing as a tool for gene therapy
• Status of genome projects for nonpathogenic bacteria and archaea
• Strategy for qualitative and quantitative analysis in proteomics based on signature peptides,
• Surfing the p53 network
• The protein-protein interaction map of Helicobacter pylori
• The use of recombinant antibodies in proteomics
• Towards a truly integrative biology through the functional genomics of yeast
• Towards the minimal eukaryotic parasitic genome
• Use of mass spectrometry-derived data to annotate nucleotide and protein sequence databases
• Use of protein-interaction maps to formulate biological questions
• Whole genomes- the foundation of new biology and medicine
• Will genomics revolutionize antimicrobial drug discovery
• Proteomic analysis
• Studying heart disease using the proteomic approach
• a major new technology for the drug discovery process
• Proteomics and genomics A selection of World Wide Web
• Proteomics and genomics Presidential preference, protein purpose
• applications in basic and applied biology
• Experimentalism in proteomics
• Guilt-by-association goes global
• Mass spectrometry and proteomics
• new perspectives, new biomedical opportunities
• Parasite Proteomics
• the industrialization of protein chemistry
• the next step after genomics
• Proteomics to study genes and genomes
• translating genomics into products
• Trends in automation and mass spectrometry for proteomics
• Using mass spectrometry for quantitative proteomics
• Proteomics
• Current status and perspectives of proteomics in aging research
• Databases and knowledge resources for proteomics research
• proteme-High-throughput purification- walk-up versus dedicated support
• Characterisation of the transition states for protein folding
• Folding and binding Emerging themes in protein folding and assembly
• Folding nuclei in proteins
• folding studies of related proteins
• Integration of genome data and protein structures
• Mechanisms of protein folding
• Practical proteomagics
• Protein design based on folding models
• Recent advances in RNA–protein recognition
• The endoplasmic reticulum- integration of protein folding, quality control, signaling and degradation

back

蛋白相互作用

• protein-protein interactions-1
• protein-protein interactions -2
• protein-protein interactions -3
• Protein-protein interactions in intracellular membrane fusion
• Protein-protein interactions define specificity in signal transduction
• A network of protein–protein interactions in yeast
• protein interactions in intracellular Ca2+-release channel function

back

• Getting in and out of the proteasome
• Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome
• Proteolysis and developmental signal transduction
• Proteolytic regulation of apoptosis
• Targeting of lysosomal proteins
• Endoplasmic reticulum-associated protein degradation

back

Biocatalysis

• Biocatalysis and biotransformation
• Industrial biocatalysis today and tomorrow
• Production of fine chemicals using biocatalysis
• Synthesis methods that exploit enzymatic activities
• Updated and improved Applied Biocatalysis
• Combinatorial and computational challenges for biocatalyst design
• Combinatorial taking the lead from Nature
• Enabling the chemistry of life
• Enzymes for chemical synthesis
• Improving enzymes by using them in organic solvents
• Modular enzymes
• NOVOZYMES — Driven by research and scientists
• biocatalysis-web　

back

脂蛋白

• high-density lipoprotein
• Are high density lipoprotein (HDL) and triglyceride levels relevant in stroke prevention
• Clinical treatment of dyslipidemia
• Divergent approaches to the treatment of dyslipidemia
• Dyslipidemia, gender, and the role of high-density lipoprotein cholesterol-implications for therapy
• Evaluating niacin in its various forms
• High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease
• ity lipoprotein cholesterol and lowering low-density lipoprotein cholesterol as adjunctive therapy to coronary artery revascularization
• lipid-Differentiating the effects of raising low levels of high-density lipoprotein cholesterol versus lowering normal triglycerides
• Nonpharmacologic management of low levels of high-density lipoprotein cholesterol
• Oxidized LDL and HDL-antagonists in atherothrombosis
• Raising high-density lipoprotein cholesterol with niacin and fibrates
• sity lipoprotein-epidemiology of low levels of high-density lipoprotein cholesterol in patients with and without coronary artery disease
• The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides
• The pharmacokinetics and pharmacodynamics of agents proven to raise high-density lipoprotein cholesterol
• ABC transporters and cholesterol metabolism
• Apolipoprotein E- a cholesterol transport protein with lipid transport-independent cell signaling properties
• Apolipoprotein(a)- structure and biology
• Fetal lipid metabolism
• Intestinal lipid absorption and transport
• Lipoprotein lipase- physiology, biochemistry, and molecular biology
• Lipoprotein subclasses and atherosclerosis
• Macrophage foam cells and atherosclerosis
• Members of the low density lipoprotein receptor family control diverse physiological processes
• Mouse models of hyperlipidemia and atherosclerosis
• POSTPRANDIAL LIPOPROTEINS AND ATHEROSCLEROSIS
• Roles of plasma lipid transfer proteins in reverse cholesterol transport
• Signposts in the assembly of chylomicrons
• Structural, biochemical and signaling properties of the low-density lipoprotein receptor gene family
• Transcriptional regulation of the human apolipoprotein genes
• lipid-binding proteins-2

• lipid-binding proteins-3

• lipid-binding proteins-4

• lipid-binding proteins-5

• Introduction- lipid-binding proteins

back

分子诊断

• Molecular Genetic Pathology- Coming of Age in the Molecular World
• New Challenges for Biomedical Research Utilizing Human Biological Materials
• Molecular Profiling of Clinical Tissue Specimens- Feasibility and Applications
• New Tools in Molecular Pathology
• Molecular Diagnosis of Epstein-Barr Virus-Related Diseases
• Molecular Diagnostic Approach to Non-Hodgkin’s Lymphoma
• The Development of a Post-Baccalaureate Certificate Program in Molecular Diagnostics

back

蛋白折叠

• Protein folds-molecular systematics in three dimensions
• protein Folding and binding Emerging themes in protein folding and assembly
• Characterisation of the transition states for protein folding
• Integration of genome data and protein structures
• Keeping it in the family- folding studies of related proteins
• Macromolecular assemblies
• Mechanisms of protein folding
• Protein design based on folding models
• The endoplasmic reticulum- integration of protein folding,
• Protein foliding-Macromolecular crowding

back

Protein technologies

• Protein folds propelled by diversity
• post-genomic cartography to understand gene function
• Advances in directed protein evolution by genetic recombination- applications to therapeutic proteins
• Analyzing single protein molecules using optical methods
• and commercial enzymes
• Creating and evaluating protein diversity
• Emerging principles of de novo catalyst design
• Engineering proteins for thermostability
• High-throughput three-dimensional protein structure determination
• In vitro display technologies- novel developments and applications
• Mapping proteinˉprotein interactions with combinatorial biology methods
• Novel concepts for selection of catalytic activity
• Novel frameworks as a source of high-affinity ligands
• Producing proteins in transgenic plants and animals
• Protein engineering by cell-surface display
• Protein interaction databases
• Using proteins in their natural environment- potential and limitations of microbial in applied biocatalysis
• The interrelationships of side-chain and main-chain conformations in proteins
• PROTEIN–LIPID INTERACTIONS

back

蛋白磷酸化（01-08）

• Kinetic and Catalytic Mechanisms of Protein Kinases
• Protein Phosphatases-A Phylogenetic Perspective
• Chemical Inhibitors of Protein Kinases
• Comparative QSAR Study of Tyrosine Kinase Inhibitors
• c-Src Tyrosine Phosphorylation of Epidermal Growth Factor Receptor
• Cyclin-Dependent Kinases
• Dynamics of cAMP-Dependent Protein Kinase
• Glycogen Synthase Kinase-3
• Growth Factor-Dependent Signaling and Cell Cycle Progression
• Histidine Phosphorylation and Two-Component Signaling in Eukaryotic Cells
• Introduction- Protein Phosphorylation and Signaling
• MAP Kinases
• Molecular Reactions of Protein Phosphatases-Insights from Structure and Chemistry
• Nonreceptor Tyrosine Phosphatases in Cellular Signaling
• Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases
• Physiological Substrates of cAMP-Dependent Protein Kinase
• Regulatory Mechanisms for Receptor Protein Tyrosine Phosphatases
• Structural Basis for Control by Phosphorylation
• Structure and Regulation of Calcium-Calmodulin-Dependent Protein Kinases

back

膜蛋白（01-08）

• Membrane Proteins Structural Biology Minireview Series
• Detergents as Tools in Membrane Biochemistry
• How Membranes Shape Protein Structure
• Membrane Targeting by C1 and C2 Domains
• Structure and Assembly of -Barrel Membrane Proteins

胰岛素生长因子（01-08）

• The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth
• IGF system, cirrhosis and liver transplantation
• Insulin-like growth factors and prostate cancer
• I receptor signalling in transformation and differentiation
• Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells
• Signalling pathways involved in antiproliferative effects of IGFBP-3
• The IGF axis and hepatocarcinogenesis
• The IGF system in thyroid cancer- new concepts
• The IGFBP system in CNS malignancy
• The three dimensional structure of the type I insulin-like growth factor receptor
• Identification of a Nonpeptide Ligand That Releases Bioactive Insulin-like Growth Factor-I from Its Binding Protein Complex

back