生物信息数据库集锦(2002)

    近几年来,随着人类基因组计划和蛋白质组工程的实施,生物信息资源不断膨胀,生物信息学的重要性日益突出。而国内外相关的生物信息数据库的数目也日益膨胀,其中有如NCBI、EMBL、SWISS-PROT等各专业中最为知名的大型数据中心,更多的,是一些从小处入手的更为专业的二级数据库。
    为帮助大家了解并有效利用这些数据库资源,CMBI从Nucleic Acids Research等杂志中摘录了各专业相关网站的评述近二百篇供各位用户选择,希望大家可以从中找到自己工作所需的数据库。(更多生物医学信息网站请查询Amos' WWW Links)


Database Category

Comparative Genomics

Gene Expression

Gene Identification and Structure

Genetic and Physical Maps

Genomic Databases

Intermolecular Interactions

Major Sequence Repositories-1

Metabolic Pathways and Cellular Regulation

Mutation Databases

Pathology

Protein Sequence Motifs

Proteome Resources

Retrieval Systems and Database Structure

RNA Sequences

Structure

Transgenics

Varied Biomedical Content

Alphabetical Database List

Protein Databases


Database Reference

5S Ribosomal RNA Database

A comprehensive leukemia database

AngioDB-database of angiogenesis and angiogenesis-related molecules

Annotating the human proteome-the Human Proteome Survey Database (HumanPSDTM) and an in-depth target database for G protein-coupled receptors (GPCR-PDTM) from Incyte Genomics

AraC-XylS database-a family of positive transcriptional regulators in bacteria

ASPD (Artificially Selected Proteins-Peptides Database)-a database of proteins and peptides evolved in vitro

ASTRAL compendium enhancements

BRENDA, enzyme data and metabolic information

CDD-a database of conserved domain alignments with links to domain three-dimensional structure

Celera Discovery SystemTM

CKAAPs DB-a Conserved Key Amino Acid Positions DataBase

Comparative Genometrics (CG)-a database dedicated to biometric comparisons of whole genomes

CSDBase-an interactive database for cold shock domain-containing proteins and the bacterial cold shock response

Database resources of the National Center for Biotechnology Information-2002 update

DBTSS-DataBase of human Transcriptional Start Sites and full-length cDNAs

DIP, the Database of Interacting Proteins-a research tool for studying cellular networks of protein interactions

DNA Data Bank of Japan (DDBJ) for genome scale research in life science

DT40 web site-sampling and connecting the genes of a B cell line

EcoCyc Database

Ensembl genome database project

euGenes-a eukaryote genome information system

Eukaryotic Promoter Database, EPD

European database on small subunit ribosomal RNA

ExInt-an Exon Intron Database

EXProt-a database for proteins with an experimentally verified function

FANTOM DB-database of Functional Annotation of RIKEN Mouse cDNA Clones

FIMM, a database of functional molecular immunology update 2002

FLAGdb-FST-a database of mapped flanking insertion sites (FSTs) of Arabidopsis

FlyBase database of the Drosophila genome projects and community literature

FUGOID-functional genomics of organellar introns database

GenBank

Gene Expression Omnibus-NCBI gene expression and hybridization array data repository

Gene Resource Locator-gene locus maps for transcriptome analysis

GeneNet-a database on structure and functional organisation of gene networks

Genew-the Human Gene Nomenclature Database

Genome Information Broker (GIB)-data retrieval and comparative analysis system for completed microbial genomes and more

Genomic and Proteomic Databases; Large-Scale Analysis and Integration of Data

Genomic database resources for Dictyostelium discoideum

Gramene-a resource for comparative grass genomics

GTOP-a database of protein structures predicted from genome sequences

HERVd-database of human endogenous retroviruses

HGVbase-a human sequence variation database emphasizing data quality and a broad spectrum of data sources

Histone Database

Homophila-human disease gene cognates in Drosophila

HOWDY-an integrated database system for human genome research

HOX Pro DB-the functional genomics of hox ensembles

HUGE-a database for human large proteins identified in the Kazusa cDNA sequencing project

HugeIndex-a database with visualization tools for high-density oligonucleotide array data from normal human tissues

human (PEDB) and mouse (mPEDB) Prostate Expression Databases

IDR-the ImmunoDeficiency Resource

IMB Jena Image Library of Biological Macromolecules-2002 update

InBase-the Intein Database

JSNP-a database of common gene variations in the Japanese population

KEGG databases at GenomeNet

LIGAND-database of chemical compounds and reactions in biological pathways

MAGEST-Maboya Gene Expression patterns and Sequence Tags

MagnaportheDB-a federated solution for integrating physical and genetic map data with BAC end derived sequences for the rice blast fungus Magnaporthe grisea

MDB-a database system utilizing automatic construction of modules and STAR-derived universal language

MDB-the Metalloprotein Database and Browser at The Scripps Research Institute

MEROPS-the protease database

MIPS-a database for genomes and protein sequences

MIPS Arabidopsis thaliana Database (MAtDB)-an integrated biological knowledge resource

MitoNuc-a database of nuclear genes coding for mitochondrial proteins. Update 2002

MMDB-Entrez’s 3D-structure database

MODBASE, a database of annotated comparative protein structure models

Molecular Biology Database Collection-2002 update

NCIR-a database of non-canonical interactions in known RNA structures

NUREBASE-database of nuclear hormone receptors

Olfactory Receptor Database-a metadata-driven automated population from sources of gene and protein sequences

Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

PALS db-Putative Alternative Splicing database

PASS2-a semi-automated database of Protein Alignments Organised as Structural Superfamilies

Pfam Protein Families Database

PharmGKB-the Pharmacogenetics Knowledge Base

PlantCARE, a database of plant cis-acting regulatory elements and a portal to tools for in silico analysis of promoter sequences

PLANT-PIs-a database for plant protease inhibitors and their genes

PlasmoDB-the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data

Predictome-a database of putative functional links between proteins

PRINTS and PRINTS-S shed light on protein ancestry

Progenetix.net-an online repository for molecular cytogenetic aberration data

PROSITE database, its status in 2002

Protein Data Bank-unifying the archive

Protein Information Resource-an integrated public resource of functional annotation of proteins

ProTherm, Thermodynamic Database for Proteins and Mutants

quest to deduce protein function from sequence-the role of pattern databases

Rat Genome Database (RGD)-mapping disease onto the genome

READ-RIKEN Expression Array Database

Recent improvements to the SMART domain-based sequence annotation resource

RiceGAAS-an automated annotation system and database for rice genome sequence

RIDOM-Ribosomal Differentiation of Medical Micro-organisms Database

Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO)

SCOP database in 2002-refinements accommodate structural genomics

SCOR-a Structural Classification of RNA database

SELEX_DB-a databaseon in vitro selected oligomers adapted for recognizing natural sites and for analyzing both SNPs and site-directed mutagenesis data

Sentra, a database of signal transduction proteins

S-MARt DB-a database on scaffold-matrix attached regions

SubtiList-the reference database for the Bacillus subtilis genome

SUPERFAMILY-HMMs representing all proteins of known structure

suPFAM—a database of potential protein superfamily relationships derived by comparing sequence-based and structure-based families

SWEET-DB-an attempt to create annotated data collections for carbohydrates

SYSTERS, GeneNest, SpliceNest-exploring sequence space from genome to protein

tGRAP, the G-protein coupled receptors mutant database

The androgen receptor gene mutations database

The EMBL Nucleotide Sequence Database

The MetaCyc Database

The Mouse Genome Database (MGD)-the model organism database for the laboratory mouse

The SBASE protein domain library, release 9.0-an online resource for protein domain identification

The tmRNA Website-invasion by an intron

TRANSCompel-a database on composite regulatory elements in eukaryotic genes

Transcription Regulatory Regions Database (TRRD)

Transterm-a database of mRNAs and translational control elements

TRIPLES database-a community resource for yeast molecular biology

TTD-Therapeutic Target Database

Update of AMmtDB-a database of multi-aligned Metazoa mitochondrial DNA sequences

UTRdb and UTRsite-specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs

VirOligo-a database of virus-specific oligonucleotides

Wanda-a database of duplicated fish genes

yMGV-helping biologists with yeast microarray data mining

YPL.db-the Yeast Protein Localization database

 


更新于 2002-02-10