最近国外有学者提出，心血管病是一种慢性炎症和自身免疫性疾病的观点，认为免疫和炎症是内在和外在危险因素致心血管再塑和发病的中介和中心环节，应用抗炎和免疫调节治疗可以有效控制心血管疾病的发生和发展。这不仅进一步揭示了心血管病的发病本质，而且为在今后15年内研究和攻克心血管病提出了新的方向和道路。 CMBI在本期开辟了炎症、免疫与心血管疾病相关的专题，以供大家参考。
Atherosclerosis- Is atherosclerosis a cellular or humoral mediated autoimmune disease atrial natriuretic peptide regulates the production of inflammatory mediators in macrophages Endothelial Atheroprotective and Anti-inflammatory Mechanisms Greater exposure to viruses increases risk of heart disease High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis Inflamm-aging- An Evolutionary Perspective on Immunosenescence Inflammation and Atherothrombosis Inflammatory Mechanisms and Persistence of Atrial Fibrillation Regulation of Immune Mechanisms in Atherosclerosis Role of Adaptive Immunity in Atherosclerosis Carotid Artery Ligation Induces Platelet-Leukocyte–Dependent Luminal Fibrin, Required for Neointima Development inflammatory response in myocardial infarction role of scavenger receptors in the innate immune system Scavenger Receptor Expression in Human Monocyte-Macrophages and THP-1 Cells - A Potential Mechanism of Increased Atherosclerosis in Hypertension vascular dendritic cells in atherosclerotic arteries Activation of the immune system and coronary artery disease Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats Angiotensin II Induces Leukocyte–Endothelial Cell Interactions In Vivo Via AT1 and AT2 Receptor–Mediated P-Selectin Upregulation Angiotensin, Inflammation, Hypertension, and Cardiovascular Disease Antibodies Against Oxidized LDL and Carotid Artery Intima-Media Thickness Antibodies to Oxidized LDL in Relation to Carotid Atherosclerosis Antiinflammatory and Antiarteriosclerotic Actions of HMG-CoA Reductase Inhibitors Anti-Inflammatory Mechanisms in the Vascular Wall Apolipoprotein J-clusterin limits the severity of murine autoimmune myocarditis Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media Association Between Influenza Vaccination and Reduced Risk of Brain Infarction Association Between Pulse Pressure and C-Reactive Protein Association of C-reactive protein with markers of prevalent atherosclerotic disease Atherosclerosis — An Inflammatory Disease Atherosclerosis—An autoimmune disease Atorvastatin reduces NF-κB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells Blood Pressure and Inflammation Cardiac fibrosis and inflammation Cardiotrophin-1 can protect cardiac myocytes Cardiovascular Disease, Interleukin-6, and Risk of Mortality CD4+ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis CD40 signaling and plaque instability , CD40 Signaling and Plaque Instability CD40-CD40L Interactions in Atherosclerosis Chlamydia pneumoniae Infection in Circulating Human Monocytes Is Refractory to Antibiotic Treatment Chronic Infections and the Risk of Carotid Atherosclerosis circulating cytokines in chronic heart failure Circulating Immune Complexes in 50-Year-Old Men as a Strong and Independent Risk Factor for Myocardial Infarction C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease C-Reactive Protein as a Cardiovascular Risk Factor C-Reactive Protein- Linking Inflammation to Cardiovascular Complications CXC-chemokines, a new group of cytokines in congestive heart failure Cytokines and Cytokine Receptors in Advanced Heart Failure Cytokines as Emerging Targets in the Treatment of Heart Failure Cytokines in atherogenesis Decreased natural killer cell activity is associated with atherosclerosis Detection of Lipid Pool, Thin Fibrous Cap, and Inflammatory Cells in Human Aortic Atherosclerotic Plaques by Near-Infrared Spectroscopy Effect of Immune Deficiency on Lipoproteins and Atherosclerosis in Male Apolipoprotein E–Deficient Mice Effects of interleukin-10 on monocyte-endothelial cell adhesion and MMP-9-TIMP-1 secretion Effects of sex and age on atherosclerosis and autoimmunity Effects of statins on vascular wall- vasomotor function, inflammation, and plaque stability Elevation of Plasma High-Density Lipoprotein Concentration Reduces Interleukin-1–Induced Expression of E-Selectin in an In Vivo Model of Acute Inflammation Elevation of Tumor Necrosis Factor- and Increased Risk of Recurrent Coronary Events After Myocardial Infarction Evolutionary Biology, Inflammation, Infection, and the Causes of Atherosclerosis High-Sensitivity C-Reactive Protein and Atherosclerosis- From Theory to Therapy Homocysteine Induces Expression and Secretion of Monocyte Chemoattractant Protein-1 and Interleukin-8 in Human Aortic Endothelial Cells - Implications for Vascular Disease Immune Mechanisms in Atherosclerosis Immune recognition of OxLDL in atherosclerosis Immunity, atherosclerosis and cardiovascular disease Immunomodulating Therapy With Intravenous Immunoglobulin in Patients With Chronic Heart Failure Immunopathogenesis of Atherosclerosis Immunoreceptor Tyrosine-Based Activation Motif Play Pivotal Role in Initiation and Generation of Neointimal Hyperplasia After Vascular Injury Impact of Infectious Burden on Extent and Long-Term Prognosis of Atherosclerosis Implications for Immune Targeting and Cardiovascular Disease In Vivo Downregulation of T Helper Cell 1 Immune Responses Reduces Atherogenesis Increased CD8+ T Cells Associated With Chlamydia pneumoniae in Symptomatic Carotid Plaque Infection and Inflammation Induce LDL Oxidation In Vivo Infections, Immunity, and Atherosclerosis Infections, Inflammation, and the Risk of Coronary Heart Disease Inflammation – fanning the flames of cardiovascular disease Inflammation and Thrombosis Inflammation- Chronic Inflammatory Cytokines Stimulate Adrenomedullin Expression Inflammatory gene polymorphisms and ischaemic heart disease Inflammatory pathways in atherosclerosis and acute coronary syndromes Influence of HMG–CoA reductase inhibitors on markers of coagulation, systemic inflammation and soluble cell adhesion Inhibition of CD40 signaling limits evolution of established atherosclerosis Interaction between monocytes and vascular endothelial cells induces adrenomedullin production Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction Interleukin-10 Inhibits Intimal Hyperplasia After Angioplasty or Stent Implantation in Hypercholesterolemic Rabbits Kinin B1 receptors and the cardiovascular system LDL Immunization Induces T-Cell–Dependent Antibody Formation and Protection Against Atherosclerosis Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis Low Circulating Vitamin B6 Is Associated With Elevation of the Inflammation Marker C-Reactive Protein Independently of Plasma Homocysteine Levels Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes Markers of inflammation as predictors in cardiovascular disease Mechanism of Arterial Infection by Chlamydia pneumoniae molecular role of mast cells in atherosclerotic cardiovascular disease Monocyte-Macrophage Regulation of Vascular Calcification In Vitro Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity Negative Regulation of Inflammation by Fas Ligand Expression on the Vascular Endothelium Network of Vascular-Associated Dendritic Cells in Intima New Anti–Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E New insights into the pathophysiological role for cytokines in heart failure Non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease Novel Clinical Markers of Vascular Wall Inflammation Oligoclonal T Cell Expansions in Atherosclerotic Lesions Overexpression of Eotaxin and the CCR3 Receptor in Human Atherosclerosis - Using Genomic Technology to Identify a Potential Novel Pathway of Vascular Inflammation Pathogenesis of venous thrombosis Perivascular Inflammation After Balloon Angioplasty Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction PPAR Activators Inhibit Tissue Factor Expression and Activity in Human Monocytes Procoagulant and proinflammatory activity in acute coronary syndromes Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions Risk of Myocardial Infarction and Angina in Patients With Severe Peripheral Vascular Disease- Predictive Role of C-Reactive Protein role of chemokines in human cardiovascular pathology Role of Monocyte Chemoattractant Protein-1 in Cardiovascular Remodeling Role of novel markers of inflammation in patients with stable coronary heart disease Roles of P-Selectin in Inflammation, Neointimal Formation, and Vascular Remodeling Secretory phospholipase A elicits proinflammatory for atherogenesis Serum Vitamin C Concentration Is Low in Peripheral Arterial Disease and Is Associated With Inflammation and Severity of Atherosclerosis Simvastatin Has Anti-Inflammatory and Antiatherosclerotic Activities Independent of Plasma Cholesterol Lowering Soluble P-Selectin and the Risk of Future Cardiovascular Events Stimulation of arteriogenesis- a new concept for the treatment of arterial occlusive disease Stress, inflammation and cardiovascular disease Suppression of Inflammation in Primary Systemic Vasculitis Restores Vascular Endothelial Function- Lessons for Atherosclerotic Disease T-Cell Factor Signaling Cascade in Vascular Remodeling T-cell immunity in acute coronary syndromes T-Cell Immunity in Acute Coronary Syndromes-1 T-Cell–Mediated Lysis of Endothelial Cells in Acute Coronary Syndromes The continuous administration of aspirin attenuates atherosclerosis in apolipoprotein E-deficient mice The inflammatory response in myocardial infarction The multiple mechanisms by which infection may contribute to atherosclerosis development and course The role of neutrophils in myocardial ischemia–reperfusion injury Tissue Factor, the Emerging Link Between Inflammation, Thrombosis, and Vascular Remodeling Transfer of CD4+ T Cells Aggravates Atherosclerosis Tumor Necrosis Factor and Endothelial Cell Death Tumor necrosis factor in CHF Tumor necrosis factor in myocardial hypertrophy and ischaemia Upregulation of CD40 and CD40 Ligand (CD154) in Patients With Moderate Hypercholesterolemia Vaccination against infections by Chlamydia pneumoniae Vascular Remodeling in Hypertension- Roles of Apoptosis, Inflammation, and Fibrosis Vascular Remodeling in Hypertension Atherosclerosis High titres of serum antinuclear antibodies, mostly directed against nucleolar antigens, are associated with the presence of coronary atherosclerosis Inflammation in acute coronary syndromes Inflammatory gene polymorphisms and ischaemic heart disease Tumour necrosis factor gene polymorphism- a predisposing factor to non-ischaemic myocardial dysfunction Early inflammatory-immunological lesions in juvenile atherosclerosis
更新于 2002-03-02
