| May 31, 2001 |
Percutaneous In Situ Coronary Venous Arterialization |
|
...We
report the use of a catheter-based system for arterializing the
adjacent anterior cardiac vein in a patient with chronic total
occlusion of the left anterior descending coronary artery... |
| May 30, 2001 |
mRNA turnover |
|
Nuclear RNA-binding proteins can record
pre-mRNA processing events in the structure of messenger ribonucleoprotein particles
(mRNPs). |
| May 29, 2001 |
International standards in laboratory
medicine |
|
International
standards play an important role in establishing quality
systems. A considerable number of standards have been created by
ISO and CEN for medical laboratories. Standards can be looked
upon in a hierarchal manner but most standards are produced in
similarly with iterative consultations and review by the
intended users. |
| May 28, 2001 |
Switch-based mechanism of kinesin
motors |
|
Kinesin
motors are specialized enzymes that use hydrolysis of ATP to
generate force and movement along their cellular tracks,
themicrotubules. |
| May 27, 2001 |
Beyond Insomnia: Strategies of
Circadian Genomics |
|
With people flying
across time zones in ever-increasing numbers, jet lag is
attracting lots of attention. In fact, research on biological
rhythms is now a hot area in genomics. |
| May 26, 2001 |
APOPTOSIS:Death of a Monopoly? |
|
Programmed cell
death (PCD, also called apoptosis or physiological cell death),
a common and evolutionarily conserved property of all metazoans,
is an essential part of life. In many fundamental biological
processes such as development and the strictly regulated
cellular homeostasis, PCD is required to eliminate unwanted and
supernumerary cells. |
| May 25, 2001 |
The Discovery of Type 1 Diabetes |
|
The
etiological heterogeneity of idiopathic diabetes has been
recognized for 25 years, and subdivision into type 1 and type 2
diabetes is fundamental to the way we think about the disease.
|
| May 24, 2001 |
Biomarkers for Early Detection of Colon Cancer |
|
There is an increasing
demand for biomarkers in colon cancer for risk assessment, early
detection, prognosis, and surrogate end points. |
| May 23, 2001 |
Control of a Genetic Regulatory Network by a Selector Gene |
|
The formation of many complex
structures is controlled by a special class of transcription
factors encoded by selector genes. |
| May 22, 2001 |
Whole-cell simulation: a grand challenge of the 21st century |
|
Study of the cell will never be complete unless its dynamic behavior is
understood. The complex behavior of the cell cannot be determined or
predicted unless a computer model of the cell is constructed and computer
simulation is undertaken. |
| May 21, 2001 |
Proteomics: a technology-driven and
technology-limited discovery science |
|
An emerging field
for the analysis of biological systems is the study of the
complete protein complement of the genome, the ‘proteome’.
There are several complementary tools available for proteome
analysis including... |
| May 20, 2001 |
Continuous recycling: a mechanism for modulatory signal transduction |
|
Modulatory signal transduction commonly requires
efficient ‘on demand’assembly of specific multicomponent
cellular machines that convert signals to cellular actions. This
article suggests that for these signaling machines to detect and
respond to fluctuations in signal strength, they must be
continuously disassembled in an energy-dependent process that
probably involves molecular chaperones. |
| May 19, 2001 |
DISCOVERY(April 2001) - our genome’s
geography |
|
Obesity
Gene, Dangerous Beauty, Protein Fights HIV, Human Genome
Sequenced, Stories from the Genome, SNP Map, Rett Syndrome. |
| May 18, 2001 |
The Nuclear Pore Complex as a
Transport Machine |
|
Eukaryotic
cells separate the nuclear synthesis of DNA and RNA from
cytoplasmic protein synthesis with a barrier termed the nuclear
envelope (NE). The NE is perforated by large proteinaceous
assemblies, called nuclear pore complexes (NPCs), which act as
the sole gatekeepers controlling the exchange of material
between the two locales. |
| May 17, 2001 |
The case of CO signaling: why the jury
is still out |
|
CO is a
signaling agent cite circumstantial evidence: CO is synthesized
in vivo by heme oxygenase (HO), HO colocalizes with soluble
guanylate cyclase (sGC) in numerous brain regions (2), and HO
knockout mice demonstrate enteric dysfunction. |
| May 16, 2001 |
The impact of the Human Genome Project
on medical genetics |
|
The near completion
of the Human Genome Project stands as a remarkable achievement,
with enormous implications for both science and society.
|
| May 15, 2001 |
Computing Comes to Life |
|
Biologists and computer scientists have designed
digital logic gates based on the metabolism of living cells,
with the aim of eventually building a computer out of colonies
of Escherichia coli or some other single-celled organism. |
| May 14, 2001 |
The role of MHC class II-restricted tumor antigens
and CD4+ T cells in antitumor
immunity |
|
Both clinical and animal studies suggest that
therapeutic strategies that have mainly focused on the use of CD8+
T cells (and MHC class I-restricted tumor antigens) are not
effective in eliminating cancer cells. Recent interest has been
directed towards the use of CD4+ T cells in generating antitumor
immunity. |
| May 13, 2001 |
The parts list of life |
|
The genome has turned out to be
a relatively poor source of explanation for the differences
between cells or between people.
|
| May 12, 2001 |
Molecular targets for breast cancer therapy and prevention |
|
The recent completion of the
human genome sequence has raised great hopes for the discovery
of new breast cancer therapies based on newly-discovered genes
linked to breast cancer development and progression. Here we
describe breast cancer therapies that have emerged from
gene-based scientific efforts over the past 20 years and that
are now approved for clinical testing or treatment. |
| May 11, 2001 |
Breast cancer genetics: What we know and what we
need |
|
Unanswered questions include the
number and nature of genetic variants that predispose women to
breast cancer, the interplay between those variants and
environmental factors, and the optimal use of that information
to reduce both the personal and social costs of breast cancer. |
| May 10, 2001 |
Journal impact factors: a `bioequivalence' issue? |
|
Journal impact
factors (IMFs) are used increasingly by institutions as
performance indicators of the quality of `individual research
output'. |
| May 9, 2001 |
Gene transfer of antisense hypoxia inducible
factor-1 a enhances the therapeutic efficacy of cancer
immunotherapy |
|
Solid tumors meet
their demands for nascent blood vessels and increased glycolysis,
to combat hypoxia, by activating multiple genes involved in
angiogenesis and glucose metabolism. |
| May 8, 2001 |
The Mitochondrion: Is It Central to Apoptosis? |
|
Researchers studying apoptosis are divided
into two camps. At issue: whether the mitochondria or enzymes
called caspases are primary in triggering programmed cell death.
|
| May 7, 2001 |
Differentiation of Embryonic Stem Cell Lines Generated from Adult Somatic Cells by Nuclear Transfer |
|
ntES cells contributed to an extensive variety of cell types,
including dopaminergic and serotonergic neurons in vitro and germ cells in vivo. |
| May 6, 2001 |
Molecular markers predictive of
response to chemotherapy in gastrointestinal tumors |
|
Gastrointestinal
cancers account for a large amount of human tumors. Surgery is
the standard treatment for localized gastrointestinal cancer,
but in a large number of patients, tumors are unresectable at
time of diagnosis and even when resectable, survival is often
poor. |
| May 5, 2001 |
Molecular Analyses of Oral Polio Vaccine Samples |
|
The “OPV/AIDS hypothesis” suggests
that the OPV used in this campaign was produced in chimpanzee kidney
epithelial cell cultures rather than in monkey kidney cell
cultures. |
| May 4, 2001 |
The many ways to cross the plasma membrane |
|
The which monitor
or modify molecule-specific intracellular processes, provides an
efficient way to study the temporal and spatial regulation of
protein systems that underlie basic cellular functions. |
| May 3, 2001 |
Postgenomic technologies: hunting the genes for common disorders |
|
The publication of a draft sequence of 90% of the
human genome heralds an exciting era in human genetics research.
In the past 20 years, efforts have focused on mapping and cloning the genes for about
1000 human genetic disorders. |
| May 2, 2001 |
Gearing up for the post-genome world |
|
To deliver on the
promise of the genome, scientists are developing highthroughput
tools, and the tools themselves are fueling a revolution in
biology. |
| May 1, 2001 |
Do Centrosome Abnormalities Lead to Cancer? |
|
Evidence suggests that at least some cancers arise because
centrosome malfunction causes chromosome damage and missorting.
|
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