2002 Star - RNAi



CMBI 新年特别奉献： 2002年度科学明星 —— Small RNA
2002年6月，CMBI曾经以RNAi为主题，收集整理了110多篇专题文献作了一次特别报道（见RNA&RNAi）。12月20日,Science杂志将"Small RNA & RNAi"评为2002年度的最耀眼的明星！同时，Nature杂志亦将Small RNA评为年度重大科技成功之一(详见CMBI每日一文Science/Nature年度特别版)。RNA研究的突破性进展，是生物医学领域近20年来，可与HGP相提并论的最重大成果之一。 RNAi最主要的功能特色在于,它可以调节和关闭基因的表达，进而调控细胞的各种高级生命活动。这不仅提升了人们对RNA分子的认识，还会大大推进基因功能的研究，更为各种劣性传染病的防治和肿瘤等医学顽症的根治，开辟了一条新的有效的途径。因此，Small RNA与RNAi的研究与应用，具有极其重要的理论和实际意义，它将对医学生物学的发展，产生深远的影响。 CMBI继2002年6月推出特别报道以来，又收集了一些近期的文献及相关网络资源与实验室链接，特此刊载，供读者阅读参考。更多的文献资料，请用"RNA"、"RNAi"等关键词，查阅"CMBI综述查询"。

CMBI综述评论
RNAi - 双链RNA引起的基因敲除 RNAi Slides Download (PPT)


近期综述文献
Breakthrough Of The Year: Small RNAs Make Big Splash Science Small RNAs: The genome's guiding hand? Nature RNA Silencing- The Genome's Immune System Glimpses of a Tiny RNA World Dicing Up RNAs RNAi and related mechanisms and their potential use for therapy RNA-RNomics- identification and function of small, non-messenger RNAs RNAi and Heterochromatin--a Hushed-Up Affair An RNA-Guided Pathway for the Epigenome Small Interfering RNAs: A Revolutionary Tool for the Analysis of Gene Function and Gene Thrapy Ancient Pathways Programmed by Small RNAs An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans An Extensive Class of Small RNAs in Caenorhabditis elegans Analysis of a piwi-Related Gene Implicates Small RNAs in Genome Rearrangement in Tetrahymena Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Establishment and Maintenance of a Heterochromatin Domain Methylation of Histone H3 at Lysine 9 Targets Programmed DNA Elimination in Tetrahymena Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi Role for a bidentate ribonuclease in the initiation step of RNA interference Small RNAs Correspond to Centromere Heterochromatic Repeats RNA-Intracellular mRNA localization- motors move messages RNA Interference Reveals a Requirement for Myocyte Enhancer Factor 2A in Activity-dependent Neuronal Survival RNAi functions in cultured mammalian neurons A Chromosome RNAissance ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants Inhibition of cdk2 activating phosphorylation by mevastatin Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action Regulation of Notch Signaling by O-Linked Fucose RNA interference of HIV replication Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi Specific and potent RNA interference in terminally differentiated myotubes Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span The dsRNA Binding Protein RDE-4 Interacts to Direct RNAi in C. elegans Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA Trypanosome Mitochondrial 3' Terminal Uridylyl Transferase (TUTase) Gene Control by Vitamin-RNA Interactions Retroviral delivery of small interfering RNA into primary cells RNA Interference Reveals a Requirement for Myocyte Enhancer Factor 2A in Activity-dependent Neuronal Survival Tissue-specific RNA interference in postimplantation mouse embryos A microRNA in a Multiple-Turnover RNAi Enzyme Complex RNA Interference-A New Weapon against HIV and Beyond siRNA-mediated gene silencing in vitro and in vivo Gene Silencing in Mammal By Small Interfering RNAs Gene-silencing in therapeutic intervention RNAi takes on DNA Confirming Specificity of RNAi in Mammalian Cells Antisense-RNA regulation and RNA interference Killing of leukemic cells with a BCR-ABL fusion gene by RNA interference Targeting an Animal Virus-News from the Front human cervical carcinoma cells treated with siRNA, a primer of RNA interference RNA-RNAi functions in cultured mammalian neurons Efficient delivery of siRNA for inhibition of gene expression in postnatal mice Inhibition of glioma growth by tumor-specific activation of double-stranded RNA–dependent protein kinase PKR RNA interference-listening to the sound of silence Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi RNA interference-antiviral defense and genetic tool Suppression of Gene Expression by RNA Interference in Cultured Plant Cells Combinatorial RNAi-a method for evaluating the functions of gene families Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi Micro-RNAs-small is plentiful Silencing viruses with RNA Control of developmental timing by small temporal RNAs Inhibition of Viral Gene Expression and Replication in Mosquito Cells by dsRNA-Triggered RNA Interference Nature abhors a double-strand Novel Genomic cDNA Hybrids Produce Effective RNA Interference
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相关网络资源
The RNA World Website Substantial collection of Web links to an array of RNA-related resources, from databases to tutorials; maintained by the Institute of Molecular Biotechnology, Jena. RNA Interference and Gene Silencing: History and Overview Brief survey of historical development of RNAi science, from Ambion Inc. RNAi Information on the Web A comprehensive list of papers, labs, and other resources focused on RNAi, provided by Orbigen, Inc. RNA Webring Collection of Web sites of molecular biology groups interested in various aspects of RNA. Developmental Biology: RNAi Interesting discussion of RNAi, on Web site developed to accompany textbook by S. F. Gilbert. RNAi Database Catalog of results from RNAi phenotypic analysis of C. elegans genes. The siRNA User Guide Protocols for siRNA preparation for Drosophila knockout experiments, and links to commercial sources for siRNAs. The RNA Society
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相关实验室链接
Robin Allshire (Wellcome Trust Center for Cell Biology) Victor Ambros (Dartmouth Medical School) David Bartel (MIT) Martin A. Gorovsky (University of Rochester) Ronald H. A. Plasterk (Hubrecht Laboratory) Phil Sharp (MIT) Thomas Tuschl (Max Planck Institute for Biophysical Chemistry) Phillip D. Zamore (University of Massachusetts Medical School)
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年度专题汇总
Science:Breakthrough of the Year 2002 CMBI述评 Nature: Context of Science in 2002
更新于2002-12-28