chemokine



Chemokine
趋化因子是当今国内外医学生物学研究的热点之一，随着人类基因组计划的完成和生物信息学的迅速发展，近年来有数十种新的趋化因子得以克隆化。功能研究表明，趋化因子在胚胎发育、血管生成、炎症、肿瘤、艾滋病等机体多种生理和病理过程中发挥重要作用，部分趋化因子的衍生物或抑制物具有潜在的临床应用前景。趋化因子的研究有着重要的理论意义和应用价值。为推动我国在趋化因子领域研究工作的开展北京大学人类疾病基因研究中心将于2002年8月在北京大学医学部举办"全国趋化因子理论与实验学习班"，为此，我们收集了趋化因子及其受体的最新报道和文献200多篇，并作了较系统的分类，列举如下，以方便学员和读者查阅，更多的文献，请查阅cmbi的综述查询和相关栏目:
chemokine receptor and signal transduction chemokine and immunization chemokine and disease clinical application	chemokine receptor and signal transduction pseudoexons and regulatory elements in the genomic sequence of the b-chemokine,alternative macrophage activation-assoclated CC-ck(AMAC)-1 The Biology of Chemokines and their Receptors regulation of calcium currents by cks and their receptor CHEMOKINES AND CHEMOKINE RECEPTORS: Biology and Clinical Relevance in Inflammation and AIDS1 chemokines and their receptors the CCcks MDC and TARC induce platelet activation via CCR4 chemokines and their receptor in allograft rejection A new SIV co-receptor, STRL33 myocardial expression of CC-and CXC-chemokines and their receptors in human end-stage heart failure regulation of tyrosine kinase activation and granule release through b-arrestin by CXCR1 Blocking Chemokine Receptors Chemokine receptors in lymphoid organ homeostasis Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses ck receptors keys to AIDS pathogenesis adhesion receptors on haematopoietic progenitor cells OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase chemokine receptor antagonists chemokine receptors Chemokine Receptor CCR5 Signals through SHP1, SHP2, and Syk gene conversion among chemokine receptors the chemokine/chemokine receptor family:potential and progress for threrapeutic intervention cell cytle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity Regulation of tyrosine kinase activation and granule release through -arrestin by CXCR1 Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development expression and regulation of chemokine receptors in human natural killer cells chemokine receptor and their role in inflammation and inflections disease international union of phermacology.XXIL nomenclature for chemokine receptor CCR5 provides a signal for microbial induced production of IL-12 by CD8a+ demdritic cells chemokine cignalling:pivoting around multiple phosphoinositide 3-kinases NFkB-dependent signaling pathways chemokined-linking receptors to response membrance raft microdimains in chemokine receptor function CD40 signaling and plaque instability back chemokine and immunization rantes:a versatile and controversial chemokine the MCP/eotaxin subfamily of cc chemokines Chemokines and Cell Migration in Secondary Lymphoid Organs The chemokine system: redundancy for robust outputs CHEMOKINES AND CHEMOKINE RECEPTORS: Biology and Clinical Relevance in Inflammation and AIDS1 Chemokines Induce Moesin Interaction with ICAM-3 CXC, C and, CX3C Chemokine/Receptor Families Signals and Receptors Involved in Recruitment of Inflammatory Cells Chemokines: A New Classification System and Their Role in Immunity chemokines and homing of dendritic cells to the Tcell areas of lymphoid organs cks and ck-r in the pathogenesis of multiple sclerosis cks in pathology and medicine cks on the rise MCP-1 and restenosis Modulating chemokines: more lessons from viruses Identification and Characterization of a Potent, Selective, and Orally Active Antagonist of the CC Chemokine Receptor-1* cloning of CCR1,an orphan seven transmembrance receptor related to ck-r,espressed abundantly in the heart identification of a novel ck(CCL28), which binds CCR10(GPR2) the chicken chemotactic and angiogenic factor(cCAF),a CXC ck the repulsive chemokine Cytokines, virokines and the evolution of immunity dancing to the tune of chemokines chemokines:the times they are a-changin' in vivo maturation and migration of dendritic cells homocystein induces expression and secretion of monocyte chemoattractant protein-1and interleukin-8 in human aortic endothecial cells novel multi-probe RNase protection assay(RPA) set for the detection of murine ck gene expression quantitative single cell methods that identify ck and ck-expression in dendritic cells Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1 infection of endothelium with E1-E4+,but notE-E-,adenovirus gene transfer vectors enhances leukocyte adhesion and migration by modulation of ICAM-1,VCAM-1,CD34 and chemokine expression cks and leukocyte activation in the fetal circulation during preeclampsia chemokines in allergic lung inflammation Chemokines: A New Classification System and Their Role in Immunity Chemokines in allergy the role of cks in regulating cell migration during human immune responses cks and T lymphocytes :more than an attraction cks and the tissue-specific migration of lymphocytes ck production by rat alveolar macrophages is inhibited by taurine chloramine cks:a new classification system and their role in immunity cks as regulators of T cell differentiation cks,ck-r and allograft rejection endothelial cks destabilize L-selectin-mediated lymphocyte rolling without inducting selectin shedding paracrine dialogue in implantation Th2 inflammation repressed by chemokines the role of cks in linking innate and adaptive immunity transfer of the ch-r CCR5 between cells by membrance-derived microparticles:a mechanism for cellular human immunodeficiency virus 1 infection viral exploitation and subversion of the immune system through ck mimicry lymphocyte traffic control by cks ck signaling and functional responses:the role of receptor dimerization and TK pathway activation cke in lymphopolesis and lymploid organ development lymphoid neogenesis:de novo formation of lymphoid tissue in chronic inflammation through expression of homing cks cks in autoimmune disease The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses cks in inflammation and immunity cks:understanding their role in T-lymphocyte biology cks:immunology's high impact factors DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking CCR5 is characteristic of Th1 lymphocytes The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells A chemokine-driven positive feedback loop organizes lymphoid follicles Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity cks in the brain:neuroimmunology and beyond cks and ocular pathology caused by corneal infection with herpes simplex virus induction of the chemokine stromal-derived factor-1 following DNAdamage improves human stem cell function Chemokines and the Homing of Dendritic Cells to the T Cell Areas of Lymphoid Organs cks and lymphopoiesis in human thymas Chemokine signaling in inflammation celebrating chemokines the role of cks in linking innate and adaptive immunity decoy receptors:a strategy to regulate inflammatory cytokines and cks ck regulation of normal and pathologic immune responses dendritic cell migration to lymph nodes :cytokines,chemokines,and lipid mediators cytokines and cks in T lymphopoiesis and T-cell effector function inflammation in human skine:a model to study chemokine-mediated leukocyte migration in vivo back chemokine and disease Role of chemokines in the pathogenesis of asthme Advances in Immunology: Asthma Chemokines and asthma: redundancy of function or a coordinated effort? CKsand asthma:redundancy of function or a coordinated effort? Chemokines in cancer CKs and CKs-R in CNS pathology_ CKs and CH-R expression in the central neroue system CKs and their CH-R expression in the central neroue system Neuropotective activity of against N-methyl-D-aspartact Atorvastatin reduces NF-kb activation and ck expression in vascular smooth muscle cells and mononuclear cells CXC-cks,a new group of cytokines in congestive heart failure-possible role of platelets and monocytes The role of cks in human cardiovascular pathology:enhanced biological insights Role of Chemokine SDF-1/PBSF and Its Receptor CXCR4 in Blood Vessel Development Chemokines, leukocytes, and atherosclerosis Linded chromosome 16q13 cks,macrophage-perived ck,fractalking,and thymus and activation-regulated ck are expressied in human atherosclerotic lesions Chemokines CKs and atherosclerosis cks:understanding their role in T-lymphocyte biology Expression of ck-r CXC-R3 and its ligand ip-10 during humancardica allograft rejection Folic acid treatment reduces ck release from peripheral blood mononuclear cell,in hyperhomecysteinemic subject CKon the rise MCP-1 restenosis Monocyte chemoattractant protein-1 is increased in the cerebrospinal fluid of patients with ischemic stroke pleiptropic effects of cks in vascular lesion development Fourth intermational seminar on cardiovascular biology and medicine:part 2 CKon the rise MCP-1 restenosis cks:the link between inflammation,restenosis and atheosclerosis The stromal cell-derived faceor-1 ck is a potent platelet agonist highly expressed in atherosclerotic plaques Thrombocidins,microbicidal proteins from humanblood platelets,are c-terminal deletion products of CXC cks CC ck I-309 is the principal monocyte chemoattractant induced by apolipoprotein in human vascular endothelial cells interfering with ck networks-the hope for mew therapeutics Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions allergic contact dermatitis cks and disease The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis role of ck and ck-r in the gastrointestinal tract interference with the signaling capaity of ccck-r5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo Expression cloning of new receptors used by simian and human immunodeficiency viruses Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody The antigenic structure of the HIV gp120 envelope glycoprotein Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4 Chemokine signaling in inflammation ck-r and their role in inflammation and inflectious disease cks and ck-r in infectious disease critical role for a lign-affinity ck-binding protein in r-herpesvirus-induced lethal meningitis Chemokines in Neurological Trauma Models Ischemia-reperfusion of rat myocardium activates nuclear factor-kB and induces neutrophil infiltration via lipopolysaccharide-induced CXC ck cks and peripheral nerve demyelination expression of CX3CR1 ck-r on neurons and their role in neuronal survival Erratum: Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation association between polymorphism in the ck-r CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis The Human Cytomegalovirus Chemokine Receptor US28 Mediates Vascular Smooth Muscle Cell Migration CC Chemokine Receptor 2 Is Required for Macrophage Infiltration and Vascular Hypertrophy in Angiotensin II–Induced Hypertension cks and their role in airway hyper-reactivity CCR5 provides a signal for microbial induced production of IL-12 by CD8+ dendritic cells ck-r in airway disease:which receptor to target ck-r expression on B cells and effect of interferon-b inmultiple sclerosis genetic fusion of cks to a self tumor antigen induces protective,T-cell dependent antitumor immunity back clinical application Advances in Immunology: Allergy and Allergic Diseases Is there a genetic basis for resistance atherosclerosis?� Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies Diabets and Atherosclerosis Dendritic cells and immunotherapy for malignant disease Modulation of C-reactive protein-mediated monocyte_ Chemokine and leukocyte activation during preeclampsia Interactions between opooid and chemokine receptors:heterologous desensitization Physiology of Cytokine Pathways in Rheumatoid Arthritis Advances in Immunology: Allergy and Allergic Diseases Chemokines receptor:multifaceted therapeutic targets Chemokines/chemokine receptor in the central nervous system and alzheimer's disease Chemokines and alzheimer's disease Chemokines:agents for the immunotherapy of cancer? Chemokines,chemokine receptor and renal disease:from basic science to pathophysiologic and therapeutic studies Chemokines anatherosclerosis what adam smith has to say about vascular disease Viral antichemokines:from pathogenesis to drug discovery Chemokine expression in coronary circulation after coronary angioplasty as a prognostic factor for restenosis new therapeutics that modulate chemokine networks Chemokine control of HIV-1 infection chemokines in pathology and medicine chemokines:new target molecules in renal disease ck blockade disease as a therapy for renal disease cks as therapeutic targets in renal cks and disease back

更新于2002－07－28