G-Protein



G Protein
G-蛋白,又称鸟苷酸调节蛋白（guanine nucleotide regulatory protein）,是位于受体与效应底物分子之间的偶联蛋白。它存在于各个组织和细胞中，是联系外部信息(如神经递质、细胞因子、激素、活性多肽等)和胞内第二信使的中间环节，参与细胞内外信息的转导。自70年代早期发现G-蛋白及Ras等GTP结合蛋白以来，G-蛋白与信号转导关系的研究已获得重大突破，并因之获得1994年诺贝尔医学和生理学奖。G-蛋白的发现具有重要的医学意义，使人们对很多疾病有了更深一层的理解。生理学家们发现G-蛋白的结构和功能改变与心血管疾病、糖尿病、恶性肿瘤等很多重大疾病都密切相关。另外，G-蛋白偶联受体（GPCRS）还是一类非常重要的药物靶标，在当今前50种最畅销的上市药物中，20％属于G蛋白受体相关药物。最近对G-蛋白的研究又有很多新的进展，如发现G－蛋白偶联受体可以介导神经轴突生长的导向等。为了让广大师生了解G蛋白的最新进展，我们收集了G-蛋白相关的文献和报道260篇列举如下，更多的文献请查阅cmbi的综述查询和相关栏目：
cell-g protein-a newly appreciated player in G protein-coupled receptor desensitization cell-g protein-Allosteric modulation of G protein-coupled receptors cell-g protein-Characterization of RGS5 in regulation of G protein-coupled receptor signaling cell-g protein-Cloning and characterization of additional members of the G protein-coupled receptor family cell-g protein-Cloning of a novel biogenic amine receptor-like G protein-coupled receptor cell-g protein-Differential coupling of the extreme C-terminus of G protein α subunits to the G protein-coupled melatonin receptors cell-g protein-Discovery and mapping of ten novel G protein-coupled receptor genes cell-g protein-Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors cell-G protein-Endocrine Manifestations of Stimulatory G Protein -Subunit Mutations and the Role of Genomic Imprinting cell-g protein-Endocytosis and downregulation of G protein-coupled receptors cell-g protein-Endocytosis of G protein-coupled receptors- roles of G protein-coupled receptor kinases and Beta-arrestin proteins cell-G protein-Evolving Concepts in G Protein-Coupled Receptor Endocytosis cell-g protein-Extracellular signal-regulated kinases control expression of G protein-coupled receptor kinase 2 cell-g protein-G protein-coupled receptor for nicotinic acid in mouse macrophages cell-g protein-G protein-coupled receptor interacting proteins cell-g protein-G protein-coupled receptor signalling and cross-talk cell-g protein-Identification of four novel human G protein-coupled receptors expressed in the brain cell-g protein-Identification of G protein-coupled receptor genes from the human genome sequence cell-g protein-Involvement of G protein-coupled receptor kinase-6 in desensitization of CGRP receptors cell-g protein-Lessons from constitutively active mutants of G protein-coupled receptors cell-g protein-Lysophospholipids and their G protein-coupled receptors in inflammation and immunity cell-G protein-Oligomerisation of G-protein-coupled receptors cell-g protein-Orphan G protein-coupled receptors in the CNS cell-g protein-protein-coupled receptor kinases, β-arrestin-2 and associated regulatory proteins cell-g protein-Regulation of G Protein-Coupled Receptor Kinases cell-G protein-Regulator of G Protein Signaling Proteins- Novel Multifunctional Drug Targets cell-g protein-Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors cell-g protein-Structural basis of G protein-coupled receptor function cell-G protein-Structural Mimicry in G Protein-Coupled Receptors cell-G protein-The C Terminus of the Ca Channel 1B Subunit Mediates Selective Inhibition by G-Protein-Coupled Receptors cell-g protein-Trans-regulation of epidermal growth factor receptor by lysophosphatidic acid and G protein-coupled receptors cell-G-Protein-Coupled Receptor Microarrays cell-G-Protein-Coupled Receptors-Structure, Function, and Ligand Interaction cell-G-Protein-Functional Immobilization of a Ligand-Activated G-Protein-Coupled Receptor cell-G-Protein-G-Protein Subunit Dissociation Is not an Integral Part of G-Protein Action cell-G-Protein-Web Sites about G-Protein-Coupled Receptors cell-lipid signal-The Edg Family G Protein-Coupled Receptors for Lysophospholipids cell-signal-Modulation of Postendocytic Sorting of G Protein-Coupled Receptors cell-signal-Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors ck-s-Cytokines and Cancer-Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors cv-adm-Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins cv-genetices-Relation of the G Protein beta3-Subunit Polymorphism With Left Ventricle Structure and Function endocrin-Hormone-induced subcellular redistributionof trimeric G proteins Lipid Signaling-The Edg Family G Protein-Coupled Receptors for Lysophospholipids medicine-Are acetylcholine-induced acetyl groups driving fuel cells in the systems of transducin, t and G proteins ns-neurochem-Regulators of G Protein Signaling pharmacol-DIMERIZATION-An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function pharmacol-DRUG EFFICACY AT G PROTEIN–COUPLED RECEPTORS pharmacol-Measures of Efficacy Using G Proteins as Endpoints-Differential Engagement of G Proteins through Single Receptors pharmacol-Recommendations for the Nomenclature of Multimeric G Protein-Coupled Receptors pharmacol-Structural Mimicry in G Protein-Coupled Receptors pharmacol-THE BINDING SITE OF AMINERGIC G PROTEIN–COUPLED RECEPTORS cell-signal-Cellular Regulation of RGS Proteins-Modulators and Integrators of G Protein Signaling cell-signal-GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors cell-signal-How the G protein-coupled receptor activates GTP-binding protein cell-signal-Lessons from constitutively active mutants of G protein-coupled receptors cell-signal-G Protein Pathways pharmacol-G Protein-Coupled Receptor Allosterism and Complexing physiol-G PROTEINS AND OLFACTORY SIGNAL TRANSDUCTION physiol-G PROTEINS AND PHEROMONE SIGNALING physiol-G PROTEINS AND PHOTOTRANSDUCTION cell-regulation of mitochondrial physiology by organelle-associated GTP-binding proteins cell-mitochondrial-The regulation of mitochondrial physiology by organelle-associated GTP-binding proteins cell-signal-How the G protein-coupled receptor activates GTP-binding protein pharmacol-GTP-binding proteins in cell survival and demise cell-signal-G Protein Pathways cell-signal-Identification of G protein-coupled receptor genes from the human genome sequence cv-tm-Cloning and characterization of a novel regulator of G protein signalling in human platelets cell-signaling-Functional Characterization of the G Protein Regulator RGS13 imm-Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors cell-signal-RGS2-a multifunctional regulator of G-protein signaling cv-adrenergic-c-Src Tyrosine Kinase Binds the 2-Adrenergic Receptor via Phospho-Tyr-350, Phosphorylates G-protein-linked Receptor Kinase 2 cell-signaling-RGS2-a multifunctional regulator of G-protein signaling cv-Nucleotide Receptors-Physiological Regulation of G Protein-Linked Signaling cv-adrenergic-Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors cv-adrenergic-Physiological Regulation of G Protein-Linked Signaling cv-adrenergic-Increased expression of G protein-coupled receptor kinases cv-adrenergic-Evolving Concepts in G Protein-Coupled Receptor Endocytosis-The Role in Receptor Desensitization and Signaling cv-Nucleotide Receptors-G Protein Subunit Interaction with a Receptor Regulates Receptor-stimulated Nucleotide Exchange cell-signaling-G protein-coupled receptor signalling and cross-talk cell-signaling-G protein specificity-Traffic direction required cell-signaling-G protein specificity-Traffic direction required cell-signaling-G protein-coupled receptor signalling and cross-talk-Achieving rapidity and specificity cv-Nucleotide Receptors-Small GTP-Binding Proteins cell-GTP-binding proteins in cell survival and demise cell-signaling-G protein-coupled receptor interacting proteins pharmacol-Adenosine receptors-G protein-mediated signalling and the role of accessory proteins cv-genetics-G protein-coupled receptor kinase 4 gene variants in human essential hypertension cv-Adrenergic-G Protein-coupled Receptors cv-Adrenergic-G Protein-coupled Receptors. III. NEW ROLES FOR RECEPTOR KINASES AND-ARRESTINS IN RECEPTOR SIGNALING AND DESENSITIZATION cv-Adrenergic-G Protein-coupled Receptors. II. MECHANISM OF AGONIST ACTIVATION cell-signaling-G protein-coupled receptor signalling and cross-talk-Achieving rapidity and specificity cell-signaling-G protein specificity-Traffic direction required cell-signal-G protein-coupled receptor interacting proteins cv-Adrenergic-Physiological Regulation of G Protein-Linked Signaling ck-Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors drug discovery-REGULATORS OF G-PROTEIN SIGNALLING AS NEW CENTRAL NERVOUS SYSTEM DRUG TARGETS cell-signaling-Target validation of G-protein coupled receptors cv-Adrenergic-Role of G-protein availability in differential signaling by alpha 2-adrenoceptors cv-Adrenergic-Agonist-induced conformational changes in the G-protein-coupling domain of the 2 adrenergic receptor EFFICACY AT G-PROTEIN-COUPLED RECEPTORS cell-signaling-Accessory Proteins in the Biogenesis of G Protein-Coupled Receptors pharmacol-Adenosine receptors-G protein-mediated signalling and the role of accessory proteins signaling-Adenosine receptors-G protein-mediated signalling and the role of accessory proteins Signaling-G Protein Signaling and Asymmetric Cell Division physioll-Adenosine receptors-G protein-mediated signalling and the role of accessory proteins cv-heart failure-G protein-coupled receptor kinases-gotta real kure for heart failure signaling-Regulation of G Protein-Coupled Receptor Kinases Signaling-Physiological Regulation of G Protein-Linked Signaling Signaling-Evolving Concepts in G Protein-Coupled Receptor Endocytosis-The Role in Receptor Desensitization and Signaling Signaling of G12 Family of G Proteins Through a Tyrosine Kinase and a Ras-GAP Regulation of G Protein-Coupled Receptor Kinases PHARMACOL-GENETIC VARIATIONS AND POLYMORPHISMS OF G PROTEIN-COUPLED RECEPTORS-Functional and Therapeutic Implications Endocrine-Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors Endocrine-Insights into G Protein-Coupled Receptor Function Using Molecular Models Endocrine Manifestations of Stimulatory G Protein-Subunit Mutations and the Role of Genomic Imprinting endocrin-Insights into G Protein-Coupled Receptor Function Using Molecular Models drug discovery-Regulator of G Protein Signaling Proteins-Novel Multifunctional Drug Targets cv-pharmacol-Structural Mimicry in G Protein-Coupled Receptors cv-pharmacol-Regulator of G Protein Signaling Proteins-Novel Multifunctional Drug Targets cv-PHARMACOL-COMPARTMENTATION OF G PROTEIN-COUPLED SIGNALING PATHWAYS IN CARDIAC MYOCYTES cv-genetics-Molecular genetics of G proteins and atherosclerosis risk cv-cell-Signaling of G12 Family of G Proteins Through a Tyrosine Kinase and a Ras-GAP cell-Untying the Gordian Knot of Cytokinesis-Role of Small G Proteins and Their Regulators cell-Rho-related G proteins-Semaphorin-mediated axonal guidance via Rho-related G proteins bi-db-Annotating the human proteome-the Human Proteome Survey Database (HumanPSDTM) and an in-depth target database for G protein-coupled receptors (GPCR-PDTM) from Incyte Genomics signaling-The many faces of Ras-recognition of small GTP-binding proteins protein-Small GTP-Binding Proteins cv-cell-Activation of the Small GTP-binding Protein Ras in the Heart by Hypertrophic Agonists cv-CARDIOMYOPATHY-Activation of the Small GTP-binding Protein Ras in the Heart by Hypertrophic Agonists cell-signaling-Small GTP-Binding Proteins signal-Sphingosine signalling via the endothelial differentiation gene family of G-protein-coupled receptors signaling-Regulators of G-protein Signaling in Receptor Complexes Protein-protein interactions at G-protein-coupled receptors pharmAcol-Is G16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors pharmacol- Heterodimerization of G-protein-coupled receptors-pharmacology, signaling and trafficking Peptide hormone binding to G-protein-coupled receptors endocrine-Functional Significance of Oligomerization of G-protein-coupled Receptors endocrine-Activation of MAPK Cascades by G-protein-coupled Receptors drug discovery-Peptide hormone binding to G-protein-coupled receptors-Structural characterization via NMR techniques drug discovery-EFFICACY AT G-PROTEIN-COUPLED RECEPTORS cv-pharmacol-Diversity and specificity in the regulated endocytic membrane trafficking of G-protein-coupled receptors bi-db-tGRAP, the G-protein coupled receptors mutant database cv-cell-Regulators of G-protein Signaling in Receptor Complexes cell-Oligomerisation of G-protein-coupled receptors Involvement of Nuclear Factor-B and Apoptosis Signal-Regulating Kinase 1 in G-Protein–Coupled Receptor Agonist–Induced Cardiomyocyte Hypertrophy Evolving Concepts in G Protein-Coupled Receptor Endocytosis- The Role in Receptor Desensitization and Signaling Molecular Basis of Downregulation of G-Protein–Coupled Inward Rectifying K+ Current (IK,ACh) in Chronic Human Atrial Fibrillation Small GTP-Binding Proteins bi-Prediction of the coupling specificity of G protein coupled receptors to their G proteins bi-A genetic algorithm for designing gene- the G protein-coupled receptor protein superfamily bi-A genetic algorithm for designing gene- the G protein-coupled receptor protein superfamily Identification of a family of mammalian G protein-coupled receptors bi-An Expressed Sequence Tag EST- Discovery of New G-Protein Coupled Receptors Treasures throughout the life-cycle of G-protein-coupled receptors rp-Opiate tolerance and dependence- receptors, G-proteins, and antiopiates Oxidized Low-Density Lipoprotein Downregulates Endothelial Basic Fibroblast Growth Factor Through a Pertussis Toxin-Sensitive G-Protein Pathway: Mediator Role of Platelet-Activating Factor-Like Phospholipids Gγ-like (ggl) domains: new frontiers in g-protein signaling and β-propeller scaffolding Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors Endocytosis and downregulation of G protein-coupled receptors mp-G Protein Diseases Small GTP-Binding Protein Ral Modulates Regulated Exocytosis of von Willebrand Factor by Endothelial Cells ns-Ion Channels and G Protein-Coupled Receptors ns-Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors renal disease-Variable imprinting of the heterotrimeric G protein Gs -subunit within different segments of the nephron How activated receptors couple to G proteins Stimulating G Protein¨CCoupled Receptors - Cure or Cause for Heart Failure Substrate assisted catalysis ¨C application to G proteins renal disease-G PROTEIN¨CCOUPLED PROSTANOID RECEPTORS AND THE KIDNEY Gene Transfer of Heterologous G Protein–Coupled Receptors to Cardiomyocytes Gene Transfer of Heterologous G Protein–Coupled Receptors to Cardiomyocytes Differential Effects on Contractility Gene Transfer of Heterologous G Protein–Coupled Receptors to Cardiomyocytes Differential Effects on Contractility Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors Orphan G-protein-coupled receptors and natural ligand discovery physiol-Role of endocytosis in mediating downregulation of G-protein-coupled receptors Association between a polymorphism in the G protein 3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction Association between a polymorphism in the G protein β3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction physiol-G PROTEIN–COUPLED PROSTANOID RECEPTORS AND THE KIDNEY biotech-Substrate assisted catalysis – application to G proteins cv-Activation of the Small GTP-binding Protein Ras in the Heart by Hypertrophic Agonists Inhibitory effects of SR141716A on G-protein activation in rat brain Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets: Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling Cloning and direct G-protein regulation of phospholipase D from tobacco Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle Low-density lipoprotein (LDL) binds to a G-protein coupled receptor in human platelets: Evidence that the proaggregatory effect induced by LDL is modulated by down-regulation of binding sites and desensitization of its mediated signaling C825T Polymorphism of the G Protein ?3-Subunit and Antihypertensive Response to a Thiazide Diuretic Association between a polymorphism in the G protein β3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction Activator of G protein signaling 3 is a guanine dissociation inhibitor for Gai subunits t-Heterotrimeric G Protein Signaling mr-st-Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors ET-Functional Coupling of G Proteins to Endothelin Receptors Is Ligand and Receptor Subtype Specific calcium channels-Mechanisms of modulation of voltage-dependent calcium channels by G proteins Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors gene therapy-Overexpression of G Protein–Coupled Receptor Kinase-2 in Smooth Muscle Cells Attenuates Mitogenic Signaling via G Protein–Coupled and Platelet-Derived Growth Factor Receptors cv-G Proteins in Heart Disease gene therapy-Overexpression of G Protein–Coupled Receptor Kinase-2 in Smooth Muscle Cells Attenuates Mitogenic Signaling via G Protein–Coupled and Platelet-Derived Growth Factor Receptors Ca2+ Elevation Evoked by Membrane Depolarization Regulates G Protein Cycle via RGS Proteins in the Heart st-Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle st-Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle Regulatory mechanisms that modulate signalling by G-protein-coupled receptors G-protein-independent signaling by G-protein-coupled receptors Endothelial G Protein --Subunits Trigger Nitric Oxide– but not Endothelium-Derived Hyperpolarizing Factor–Dependent Dilation in Rabbit Resistance Arteries Edg-1, the G protein Ccoupled receptor for sphingosine-1-phosphate, is essential for vascular maturation 2-Adrenergic and Several Other G Protein¨CCoupled Receptors in Human Atrial Membranes Activate Both Gs and Gi Regulators of G Protein Signaling (RGS) and RGS-Like Proteins The Role of Rho in G Protein-Coupled Receptor Signal Transduction The Regulator of G Protein Signaling Family ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN¨CCOUPLED RECEPTOR REGULATION Ion Channels and G Protein-Coupled Receptors Phosphorylation of Phosducin and Phosducin-like Protein by G Protein-coupled Receptor Kinase 2 Interacts with Regulator of G Protein Signaling Proteins and Modulates Their Activity Role of Small G Proteins and Their Regulators Regulators of G Protein Signaling- A Bestiary of Modular Protein Binding Domains Regulators of G Protein Signaling (RGS) and RGS-Like Proteins Heptahelical Receptor Signaling- Beyond the G Protein Paradigm The brain-speci￠c G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31 Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins G-protein coupled receptor kinases as modulators of G-protein signalling DESENSITIZATION OF G-PROTEIN–COUPLED RECEPTORS IN THE CARDIOVASCULAR SYSTEM A G-protein signaling network mediated by an RGS protein Localization of G-protein-coupled receptors in health and disease Functional Significance of Oligomerization of G-protein-coupled Receptors Metabotropic G-protein-coupled glutamate receptors as therapeutic targets Molecular localisation of a G-protein mRNA using differential display and in situ hybridization Oxidized LDL–Induced NF-B Activation and Subsequent Expression of Proinflammatory Genes Attenuates Mitogenic Signaling via G Protein-Coupled and Platelet-Derived Growth Factor Receptors Overexpression of G Protein–Coupled Receptor Kinase-2 in Smooth Muscle Cells Attenuates Mitogenic Signaling via G Protein-Coupled and Platelet-Derived Growth Factor Receptors Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein subunits 2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine-Threonine Kinase B-Raf Regulator of G Protein Signaling RGS3T Is Localized to the Nucleus and Induces Apoptosis Localization of G-protein-coupled receptors in health and disease A G-protein signaling network mediated by an RGS protein Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors Evidence for kinship between diverse G-protein coupled receptors Ca2+-Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity Mechanical Stress?§CInduced Heat Shock Protein 70 Expression in Vascular Smooth Muscle Cells Is Regulated by Rac and Ras Small G Proteins but Not Mitogen-Activated Protein Kinases The Small G-protein Rac Mediates Depolarization-induced Superoxide Formation in Human Endothelial Cells Ca2+-Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity Using green fluorescent proteins to study G protein coupled receptor localization and trafficking The G protein ?Acirc;3 subunit polymorphism in human hypertension Activation of MAPK Cascades by G protein coupled Receptors Type-specific Sorting of G Protein-coupled Receptors after Endocytosis Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein-Coupled Receptor Kinases in the Heart PAR1 Thrombin Receptor-G Protein Interactions Impaired Vasodilator Function in Hypertension The Role of Alterations in Receptor-G Protein Coupling Beta-Adrenergic Receptor-G Protein-Adenylyl Cyclase Signal Transduction in the Failing Heart The small G-Protein Rac mediates depolarization induced superoxide formation in human endothelial Cells GTP-binding protein Budding actors in mammalian G-protein signaling Regulation of tyrosine kinase cascades by G-protein-coupled receptors

更新于2002-10-19