The Rice Genome



JAK－STAT pathway and cardiovasula system
JAK－STAT途径是信息传递中酪氨酸蛋白激酶途径的一种，很多的细胞因子和生长因子其受体分子缺乏酪氨酸蛋白激酶活性，但它们能借助细胞内的一类具有激酶结构的连接蛋白JAKs完成信息转导，这种配体与非催化型受体结合后，能活化各自的JAKs，JAKs再通过激活信号转导子和转录激动子而最终影响到基因的转录调节的途径就称为JAK－STAT信号转导通路。近年来研究表明心血管系统的很多反应都是通过JAK-STAT途径来完成信号转导的，这同时也给临床的诊断和治疗带来了新的研究思路。下面我们列举了有关JAK-STAT途径和心血管系统的最新的报道和文献，供读者参考，更多的报道请查阅cmbi的综述查询和相关栏目：
cv-cell-Jak-Stat pathway-signal-Induction of JAB-SOCS-1-SSI-1in cardiovascular system in rat treated with cardiotrophin-1 cv-cell-Jak-Stat pathway-signal-JAK-STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion cv-cell-Jak-Stat pathway-signal-ventricular myocytes under spontaneous hypertension-Role of JAK-STAT pathway cell-signaling-JAK-STAT-What does Stat3 do cell-signalnng-JAK-STAT signaling in human disease imm-Regulation of the Immune System-Cytokine Signaling in 2002-New Surprises in the Jak-Stat Pathway respir-JAK-STAT signaling in asthma cv-cell-Jak-Stat pathway-signal-A Novel Role for STAT3 in Cardiac Remodeling cv-cell-Jak-Stat pathway-signal-Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein cv-cell-Jak-Stat pathway-signal-Activation of JAK-STAT pathway transduces cytoprotective signal in rat acute myocardial infarction cv-cell-Jak-Stat pathway-signal-Activation of STAT5 during EPO-directed suppression of apoptosis cv-cell-Jak-Stat pathway-signal-Activation of the JAK-STAT pathway by reactive oxygen species cv-cell-Jak-Stat pathway-signal-An essential role of the JAK-STAT pathway in ischemic preconditioning cv-cell-Jak-Stat pathway-signal-Anti-Inflammatory Mechanisms in the Vascular Wall cv-cell-Jak-Stat pathway-signal-Biphasic Activation of the JAK-STAT Pathway by Angiotensin II in Rat Cardiomyocytes cv-cell-Jak-Stat pathway-signal-Cardiac Contractile Response in Ventricular Myocytes Under Spontaneous Hypertension-Role of JAK-STAT Pathway cv-cell-Jak-Stat pathway-signal-Cardioprotection with losartan is mediated through the inhibition of janus kinase (JAK) signal transductors and activators of transcription (STAT) cascade cv-cell-Jak-Stat pathway-signal-CELLULAR SIGNALLING PATHWAYS-NEW TARGETS IN LEUKAEMIA THERAPY cv-cell-Jak-Stat pathway-signal-Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-B cv-cell-Jak-Stat pathway-signal-cv-peptide-Inflammatory Cytokines Stimulate Adrenomedullin Expression Through Nitric Oxide cv-cell-Jak-Stat pathway-signal-Immune Mechanisms in Atherosclerosis cv-cell-Jak-Stat pathway-signal-Induction of JAB-SOCS-1-SSI-1 and Is Involved in gp130 in Cardiovascular Treated With Cardiotrophin-1 cv-cell-Jak-Stat pathway-signal-Jaks and Stats as therapeutic targets cv-cell-Jak-Stat pathway-signal-JAK-STAT signaling in human disease cv-cell-Jak-Stat pathway-signal-JAK-STAT Signaling Is Associated With Cardiac Dysfunction During Ischemia and Reperfusion cv-cell-Jak-Stat pathway-signal-Mechanical stress-induced cardiac hypertrophy cv-cell-Jak-Stat pathway-signal-Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species cv-cell-Jak-Stat pathway-signal-Negative Regulators of Cytokine Signaling cv-cell-Jak-Stat pathway-signal-Programmed cell death in the developing heart cv-cell-Jak-Stat pathway-signal-Reactive Oxygen Species Regulate Heat-Shock Protein 70 via the JAK-STAT Pathway cv-cell-Jak-Stat pathway-signal-Role of NAD(P)H Oxidase in Angiotensin II-Induced JAK-STAT Signaling and Cytokine Induction cv-cell-Jak-Stat pathway-signal-Role of the JAK-STAT Pathway in Rat Carotid Artery Remodeling After Vascular Injury cv-cell-Jak-Stat pathway-signal-Signaling by Type I and II cytokine receptors cv-cell-Jak-Stat pathway-signal-Signaling mechanisms of cytokine receptors and their perturbances in disease cv-cell-Jak-Stat pathway-signal-Signaling through the JAK-STAT pathway, recent advances and future challenges cv-cell-Jak-Stat pathway-signal-Significance of ERK cascade compared with JAK-STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy cv-cell-Jak-Stat pathway-signal-STAT family of transcription factors in cytokine-mediated biological responses cv-cell-Jak-Stat pathway-signal-STAT proteins and transcriptional responses to extracellular signals cv-cell-Jak-Stat pathway-signal-STAT-signalling through the cytoplasmic compartment-Consideration of a new paradigm cv-cell-Jak-Stat pathway-signal-The Jak-Stat Pathway and Urokinase Receptor Signaling in Human Aortic Vascular Smooth Muscle Cells cv-cell-Jak-Stat pathway-signal-The Jak-Stat pathway in normal cv-cell-Jak-Stat pathway-signal-The Jak-STAT pathway cv-cell-Jak-Stat pathway-signal-The suppressors of cytokine signaling (SOCS) proteins-Important feedback inhibitors of cytokine action cv-cell-Jak-Stat pathway-signal-Thrombin Regulates Vascular Smooth Muscle Cell Growth and Heat Shock Proteins via the JAK-STAT Pathway cv-cell-Jak-Stat pathway-signal-Thrombopoietin-a pan-hematopoietic cytokine cv-cell-Jak-Stat pathway-signal-Vascular Inflammation and Renin-Angiotensin System cv-cell-Jak-Stat pathway-signal-[beta]-Cell Apoptosis-Stimuli and Signaling cv-cell-Jak-Stat pathway-signal-CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. cv-cell-Jak-Stat pathway-signal-Cytokine signaling in sepsis cv-cell-Jak-Stat pathway-signal-Oncogenic kinase signalling cv-cell-Jak-Stat pathway-signal-Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways Reactive Oxygen Species Regulate Heat-Shock Protein 70 via the JAK-STAT Pathway Reactive Oxygen Species Regulate Heat-Shock Protein 70 via the JAK-STAT Pathway Abrogated Leptin-Induced Cardiac Contractile Response in Ventricular Myocytes Under Spontaneous Hypertension -Role of JAK-STAT Pathway Jak-STAT--cytokine-signal Interferon Induces AT2 Receptor Expression in Fibroblasts by Jak-STAT Pathway and Interferon Regulatory Factor-1 Activation of JAK-STAT pathway transduces cytoprotective signal in rat acute myocardial infarction Interleukin-6-type cytokine signalling through the gp 130-Jak-STAT pathway Role of NAD(P)H Oxidase in Angiotensin II–Induced JAK-STAT Signaling and Cytokine Induction The Jak-Stat pathway in normal and perturbed hematopoiesis An essential role of the JAK-STAT pathway in ischemic preconditioning An essential role of the JAK-STAT pathway in ischemic preconditioning cv-physiol-Emerging Role of the JAK-STAT Pathway as a Mechanism of Protection Against Ischemia sc-Stem Cell Self-Renewal Specified by JAK-STAT Activation in Response to a Support Cell Cue cell-signaling-JAK-STAT-Stat proteins and oncogenesis

更新于2002-06-22