RNA & RNAi



RNA and RNAi
众所周知,RNA在生命活动中具有重要的作用，它和蛋白共同负责基因的表达和表达过程的调控。近年来研究表明,一些小的双链RNA可以高效、特异的阻断体内基因表达，促进RNA降解，可在细胞内发挥基因敲除的作用，称为RNA干预（即RNAi）。它是体内抵御外在感染的一种重要保护机制。为此被Science评为2001年最重要的的成果之一。现将RNA和RNAi的近期报道和相关文献列举如下，以供参考：
RNAi-U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells RNAi-A Short Primer on RNAi-RNA-Directed RNA Polymerase Acts as a Key Catalyst RNAi-ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway RNAi-Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells RNAi-Effective expression of small interfering RNA in human cells RNAi-Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells RNAi-On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing RNAi-RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells RNAi-Role for a bidentate ribonuclease in the initiation step of RNA interference RNAi-U6 promoter–driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells RNAi-Double-Stranded RNA Interference with Gene Expression-RNAi RNAi-Interfering With Gene Expression RNAi-Ribosome Structure and Function RNAi-RNA Interference RNAi-RNAi chapter in Developmental Biology RNAi-A System for Stable Expression of Short Interfering RNAs in Mammalian Cells RNAi as Random Degradative PCR-siRNA Primers Convert mRNA into dsRNAs that Are Degraded to Generate New siRNAs RNAi-Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA RNAi-nature abhors a double-strand RNAi-A DNA vector-based RNAi technology to suppress gene expression in mammalian cells RNAi-A new approach to the inhibition of gene expression RNAi-A Short Primer on RNAi-RNA-Directed RNA Polymerase Acts as a Key Catalyst RNAi-An exon that prevents transport of a mature mRNA RNAi-Antisense Oligonucleotides-Basic Concepts and Mechanisms RNAi-ATP Requirements and Small Interfering RNA Structure in the RNA Interference Pathway RNAi-Bulged residues promote the progression of a loop?§Cloop interaction to a stable and inhibitory antisense?§Ctarget RNA complex RNAi-Combinatorial RNAi-a method for evaluating the functions of gene families RNAi-Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells RNAi-Epigenetics-Regulation Through Repression RNAi-Gene Activation and Gene Silencing RNAi-Gene silencing by double-stranded RNA RNAi-Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs RNAi-Genome-wide RNAi RNAI-Glimpses of a Tiny RNA World RNAi-gt-Gene silencing as a threat to the success of gene therapy RNAi-GTPase Ran Regulates Chromosome Positioning and Nuclear Envelope Assembly In Vivo RNAi-Identification of Novel Genes Coding for Small Expressed RNAs RNAi-mediated oncogene silencing confers resistance to crown gall tumorigenesis RNAi-MicroRNAs-deviants no longer RNAi-Non-coding RNAs-the architects of eukaryotic complexity RNAi-Progression of a loop?§Cloop complex to a four-way junction is crucial for the activity of a regulatory antisense RNA RNAi-Prospects for anti-ras drugs RNAi-RNA-Guiding Gene Silencing RNAi-RNA Interference Can Target Pre-mRNA RNAi-RNA interference-genetic wand and genetic watchdog RNAi-RNA interference is mediated by 21-and 22-nucleotide RNAs RNAi-RNA interference2001 RNAi-RNAi and brain function RNAi-RNAi and double-strand RNA RNAi-RNAi is antagonized by A?I hyper-editing RNAi-RNAi surges on-application to cultured mammalian cells RNAi-RNAi-mediated oncogene silencing confers resistance to crown gall tumorigenesis RNAi-Role for a bidentate ribonuclease in the initiation step of RNA interference RNAi-Running interference RNAi-Stable suppression of gene expression by RNAi in mammalian cells RNAi-Suppression of Gene Expression by Targeted Disruption of Messenger RNA-Available Options and Current Strategies RNAi-Suppression of Gene Expression by Targeted Disruption of Messenger RNA RNAi-TAPping into mRNA Export RNAi-The non-coding RNAs as riboregulators RNAi-Transcriptional silencing and promoter methylation triggered by double-stranded RNA RNAi-Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways RNAi-Using RNA interference to identify genes required for RNA interference RNA-Gene Expression-A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing RNA-Gene Expression-A Unified Theory of Gene Expression RNA-Gene Expression-Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators RNA-Gene Expression-Cooperation between Complexes that Regulate Chromatin Structure and Transcription RNA-Gene Expression-Epigenetic Codes for Heterochromatin Formation and Silencing-Rounding up the Usual Suspects RNA-Gene Expression-Gene-Specific Regulation by General Translation Factors RNA-Gene Expression-Integrating mRNA Processing with Transcription RNA-Gene Expression-Mechanisms of Subcellular mRNA Localization RNA-Gene Expression-Nuclear RNA Turnover RNA-Gene Expression-Protein Folding and Unfolding at Atomic Resolution RNA-Gene Expression-Ribosome Structure and the Mechanism of Translation RNA-Gene Expression-The Complexities of Trypanosome RNA Editing RNA-Gene Expression-The Contribution of Nuclear Compartmentalization to Gene Regulation RNA-Gene Expression-The RNA Polymerase II Machinery-Structure Illuminates Function RNA-a method to specifically inhibit PCR amplification of known members of a multigene family by degenerate primers RNA-analysis by ion-pair reversed-phase high performance liquid chromatography RNA-commutes to work-regulation of plant gene expression by systemically transported RNA molecules RNA-interference2001 RNA-polymerase II and the integration of nuclear events RNA-Targets of the Fragile X Protein RNA-Co-transcriptional splicing of pre-messenger RNAs RNA-Linear 2' O-Methyl RNA probes for the visualization of RNA in living cells RNA-Messenger RNA on the move-implications for cell polarity RNA-Micro-RNAs-small is plentiful RNA-microRNAs-Tiny Regulators with Great Potential RNA-mRNA Expression Analysis of Tissue Sections and Single Cells RNA-Non-coding RNAs RNA-Regulation of mRNA stability in mammalian cells RNA-The cross-link from the upstream region of mRNA to ribosomal protein S7 i RNA-A handful of intron-containing genes produces the lion's share of yeast mRNA RNA-bi-A computational approach to identify genes for functional RNAs in genomic sequences RNA-Coupled nucleotide covariations reveal dynamic RNA interaction patterns RNA-DExD-H Box RNA Helicases-From Generic Motors to Specific Dissociation Functions RNA-Genomic-scale quantitative analysis of yeast pre-mRNA splicing-Implications for splice-site recognition RNA-Getting the Message Across-The Intracellular Localization of mRNAs in Higher Eukaryotes RNA-Identification of Novel Genes Coding for Small Expressed RNAs RNA-Internal ribosome entry sites in eukaryotic mRNA molecules RNA–ligand chemistry-A testable source for the genetic code RNA-Maximizing RNA folding rates-A balancing act RNA-mRNA surveillance in eukaryotes RNA-mRNA surveillance in mammalian cells-The relationship between introns and translation termination RNA-NON-CODING RNA GENES AND THE MODERN RNA WORLD RNA-Nuclear RNA Export Pathways RNA-On the wobble GoU and related pairs RNA-Quantitative analysis of mRNA amplification by in vitro transcription RNA-Recognition of Nascent RNA by the Human La Antigen RNA-Recognizing the D-loop of transfer RNAs RNA-Running rings around RNA-a superfamily of phosphate-dependent RNases RNA-Short Primer on RNAi-RNA-Directed RNA Polymerase Acts as a Key Catalyst RNA-Sorting out the complexity of SR protein functions RNA-the activation and regulation of mRNA surveillance RNA-The Intracellular Localization of mRNAs in Higher Eukaryotes RNA-Translation-In retrospect and prospect RNA-Upstream Open Reading Frames as Regulators of mRNA Translation RNA_The challenge of target sequence specificity in CU RNA editing RNA-Intergenic mRNA Molecules Resulting from trans-Splicing RNA-Killing the messenger-new insights into nonsense-mediated mRNA decay RNA-Role of Nucleoporin Induction in Releasing an mRNA Nuclear Export Block RNA-Stable suppression of gene expression by RNAi in mammalian cells RNA-The emerging conceptual framework of evolutionary developmental biology RNA-Poly(A) tail synthesis and regulation-recent structural insights RNA-MESSENGER-RNA-BINDING PROTEINS AND THE MESSAGES THEY CARRY RNA-MicroRNAs-Hidden in the Genome RNA-Skiing Toward Nonstop mRNA Decay RNA-Transcription-Surprising Role for an Elusive Small Nuclear RNA RNA-An mRNA Surveillance Mechanism That Eliminates Transcripts Lacking Termination Codons RNA-Exosome-Mediated Recognition and Degradation of mRNAs Lacking a Termination Codon RNA-Using RNA interference to identify genes required for RNA interference RNA-A System for Stable Expression of Short Interfering RNAs in Mammalian Cells RNA-Computational Genomics of Noncoding RNA Genes RNA-Small Nucleolar RNAs-An Abundant Group of Noncoding RNAs with Diverse Cellular Functions RNA-Small nucleolar RNAs-an abundant group of noncoding RNAs with diverse cellular functions-1 RNA-Small RNAs in Bacteria-Diverse Regulators of Gene Expression in Response to Environmental Changes RNA-Spliceosomal snRNAs-Mg2+-Dependent Chemistry at the Catalytic Core RNA-Structure and function of the eukaryotic ribosome-the next frontier RNA-Extracellular mRNA Induces Dendritic Cell Activation by Stimulating Tumor Necrosis Factor-Secretion and Signaling through a Nucleotide Receptor RNA-MESSENGER-RNA-BINDING PROTEINS AND THE MESSAGES THEY CARRY

更新于2002-06-04