AS



Atherogenesis
动脉粥样硬化病（AS）是一种常见病、多发病，是危害人体生命健康最严重的疾病之一。我们曾在特别报道“心血管最新进展”和“炎症免疫与心血管疾病”的相关栏目中涉及到AS。最近Nature Medicine连续发表了一系列的论文，反应了目前AS研究中的热点和亮点。现将近两年有关“动脉粥样硬化形成”的文章收集起来，全文摘编如下，供大家参考。更多信息请用"AS"和"Atherogenesis"为关键词在cmbi 文献查询中查找，并可参考以前特别报道的文章。
Atherogenesis in perspective
A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis A link between diabetes and atherosclerosis A new feature on the cholesterol-lowering landscape angiotensin II signaling and an essential regulator of cardiovascular remodeling Apolipoprotein B secretion and atherosclerosis are decreased in phospholipid-transfer protein deficiency Atherosclerosis Biochemistry and molecular cell biology of diabetic complications CD40L stabilizes arterial thrombi by integrin-dependent mechanism CD99 plays a major role in the migration of monocytes through endothelial junctions Circulating activated platelets exacerbate atherosclerosis Circulating smooth muscle progenitor cells contribute to atherosclerosis Diabetic endothelial dysfunction Hematopoietic stem cells differentiate into vascular cells that participate in atherosclerosis High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells Hypercholesterolemia and inflammation as partners in crime Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair Inflammation in atherosclerosis Innate and acquired immunity in atherogenesis Insulin signalling and the regulation of glucose and lipid metabolism Interferon- elicits arteriosclerosis in the absence of leukocytes Lack of macrophage fatty-acid-binding protein aP2 protects deficient in apolipoprotein E against AS lipid mediator class switching during acute inflammation Mechanisms of angiogenesis and arteriogenesis Molecular multitasking Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis PDGF-D is a specific, protease-activated ligand for the PDGF -receptor Platelets in atherothrombosis PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism Progress in cardiovascular biology Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease Revascularization of ischemic tissues by PlGF treatment, and inhibition of atherosclerosis by anti-Flt1 Immunomodulation:A new role for statins? role of PPAR-gamma in macrophage differentiation and cholesterol uptake SCAP ligands are potent new lipid-lowering drugs Stabilization of atherosclerotic plaques- New mechanisms and clinical targets Subendothelial retention of atherogenic lipoproteins in early atherosclerosis The liver X receptor gene team- Potential new players in atherosclerosis The macrophage foam cell as a target for therapeutic intervention The potential for novel anti-inflammatory therapies for coronary artery disease Vascular endothelial growth factor enhances atherosclerotic plaque progression Vascular proliferation and atherosclerosis- New perspectives and therapeutic strategies Peripartum cardiomyopathy- a selenium disconnection and an autoimmune connection Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism back
Factors Enhancing Atherogenesis
Coronary Structural Alterations and Atherogenesis in the Dahl Sodium-Sensitive Hypertensive Rat Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis Cooperation Between Secretory Phospholipase A2 and TNF-Receptor in Atherogenesis Mitochondrial Integrity and Function in Atherogenesis cell cycle dysregulation and smooth muscle cell dysfunction in atherogenesis Potential role of dendritic cells in atherogenesis Maternal Hypercholesterolemia During Pregnancy Promotes Early Atherogenesis in LDL Receptor-Deficient Mice and Alters Aortic Gene Expression Determined by Microarray Nonoxidative modifications of lipoproteins in atherogenesis neointima-NF-B-pivotal mediator or innocent bystander in atherogenesis Cytokines in atherogenesis Lipids, Lipoproteins, and Their Receptors-Remnant Lipoproteins and Atherogenesis Mechanosensitive Endothelial Gene Expression Profiles-Scripts for the Role of Hemodynamics in Atherogenesis Secretory Phospholipase A2 Elicits Proinflammatory Changes and Upregulates the Surface Expression of Fas Ligand in Monocytic Cells -Potential Relevance for Atherogenesis AT1-Type Angiotensin Receptor in Oxidative Stress and Atherogenesis-Part II AT1 Receptor Regulation Atherogenesis and the Arginine Hypothesis Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1) in Atherogenesis Tumor Necrosis Factor Receptor and Ligand Superfamily Family Members TNFRSF14 and LIGHT-New Players in Human Atherogenesis The smooth muscle cell membrane during atherogenesis Tumor Necrosis Factor Receptor Superfamily 14 Is Involved in Atherogenesis by Inducing Proinflammatory Cytokines and Matrix Metalloproteinases Endogenous heparin activity deficiency-the `Missing Link' in atherogenesis Temporal Expression of Heat Shock Proteins 60 and 70 at Lesion-Prone Sites During Atherogenesis in ApoE-Deficient Mice The role of vitamin E in atherogenesis Oxidants in cigarette smoke extract modify low-density lipoprotein in the plasma and facilitate atherogenesis in the aorta of Watanabe heritable hyperlipidemic rabbits Induction of Rapid Atherogenesis by Perivascular Carotid Collar Placement in Apolipoprotein E–Deficient and Low-Density Lipoprotein Receptor–Deficient Mice Preferential pharmacological inhibition of macrophage ACAT increases plaque formation in mouse and rabbit models of atherogenesis Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant protein-1 via a p38 mitogen-activated protein kinase mediated pathway: Implications for atherogenesis Glycoxidation and lipid peroxidation of low-density lipoprotein can synergistically enhance atherogenesis Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000 THE ROLE OF LIPOPROTEIN(a) IN ATHEROGENESIS AND THROMBOSIS back
Factors Reducing Atherogenesis
Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis Toll-like Receptor 4 Polymorphisms and Atherogenesis Tumour necrosis factor-, inflammatory biomarkers, and atherogenesis Changing concepts of atherogenesis Heme Oxygenase-1 Inhibits Atherogenesis Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis In Vivo Downregulation of T Helper Cell 1 Immune Responses Reduces Atherogenesis The smooth muscle cell membrane during atherogenesis-A potential target for amlodipine in atheroprotection Heme Oxygenase-1 Inhibits Atherogenesis in Watanabe Heritable Hyperlipidemic Rabbits Age-Related Effects on Atherogenesis and Scavenger Enzymes of Intracranial and Extracranial Arteries in Men Without Classic Risk Factors for Atherosclerosis In Vivo Downregulation of T Helper Cell 1 Immune Responses Reduces Atherogenesis in Apolipoprotein E-Knockout Mice Endogenous Neutralizing Antibodies Against Platelet-Derived Growth Factor-AA Inhibit Atherogenesis in the Cholesterol-Fed Rabbit The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits A potential role for sterol 27-hydroxylase in atherogenesis Expression of Human Apolipoprotein A-I-C-III-A-IV Gene Cluster in Mice Induces Hyperlipidemia but Reduces Atherogenesis Influence of Helicobacter pylori Infection During Atherogenesis In Vivo in Mice Absence of EC-SOD Does Not Promote Atherogenesis in Mice: Have We Lost Yet Another Player? Decreased Coagulability Has No Clinically Relevant Effect on Atherogenesis: Observations in Individuals With a Hereditary Bleeding Tendency back
更新于2003-01-09