Natural Killer Cells

        自然杀伤细胞（Natural killer cell,NK)是粒状淋巴细胞，由于它能迅速溶解小鼠体内的特定肿瘤细胞而被发现。NK因为这种先天的细胞溶解能力而得名。在人外周血中NK细胞占淋巴细胞总数的约5％－15％，在脾中约占相似百分比。此外在肺、消化道、肝中亦有发现。前几年关于Nk细胞能溶解特定肿瘤细胞是NK的研究热点，期望能因此而找到恶性肿瘤的治疗途径。最近几年，关于NK细胞的其他其他功能，尤其是产生细胞因子的功能是另一个研究热点。NK细胞通过释放细胞因子能调节其他细胞（尤其是免疫系统的细胞）的活性。NK细胞的主要功能包括抗肿瘤、抗炎、调节造血系统、调节移植物抗宿主病、调节免疫和自身免疫以及在妊娠中的作用。鉴于NK细胞在病毒感染保护、调节免疫系统中的重要作用， CMBI特为大家准备了关于自然杀伤细胞的特别报道，更多文献敬请查阅CMBI的文献查询。

• Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
  
• ACTIVATING RECEPTORS AND CORECEPTORS INVOLVED IN HUMAN NATURAL KILLER CELL-MEDIATED CYTOLYSIS
  
• Activation of Natural Killer (NK) T Cells during Murine Cytomegalovirus Infection
  
• Crystal structure of the murine NK cell-activating receptor NKG2D
  
• Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines
  
• Genes encoding putative natural killer cell C-type lectin receptors
  
• HIV-1 Antiviral Activity of Recombinant Natural Killer Cell Enhancing Factors, NKEF-A and NKEF-B
  
• IL-15 availability conditions homeostasis of peripheral natural killer T cells
  
• In Vivo Survival and Homeostatic Proliferation of Natural Killer Cells
  
• Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
  
• Innate immunity
  
• Mouse V14i natural killer T cells are resistant to cytokine polarization in vivo
  
• Natural killer cells and viral infections
  
• Natural killer cells can mediate cardiac allograft vasculopathy
  
• NK CELL RECEPTORS
  
• NK-cell activity in immunotoxicity drug evaluation
  
• NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
  
• NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
  
• NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway
  
• On guard--activating NK cell receptors
  
• Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis
  
• Regulation of antiviral CD8+ T cells by inhibitory natural killer cell receptors
  
• REGULATION OF THE NATURAL KILLER CELL RECEPTOR REPERTOIRE
  
• Specific and nonspecific NK cell activation during virus infection
  
• STRUCTURE AND FUNCTION OF NATURAL KILLER CELL RECEPTORS
  
• The choices of a natural killer
  
• The NK cell receptor repertoire
  
• The NKG2D receptor and its ligands
  
• Turning On Natural Killer Cells
  
• ULBP4 is a novel ligand for human NKG2D
  
• Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection
  
• WHAT DOES IT TAKE TO MAKE A NATURAL KILLER
  
• NATURAL KILLER CELLS AND NATURAL KILLER T CELLS
  
• Murine natural killer cell progenitors and their requirements for development
  
• IMMUNE FUNCTIONS ENCODED BY THE NATURAL KILLER GENE COMPLEX
  
• NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus
  
• Reversible Defect in Natural Killer T Cell Function Characterizes the Progression to Malignant Myeloma
  
• Specific inhibitors of protein phosphatase 2A inhibit tumor metastasis through augmentation of natural killer cells
  
• TNF-related apoptosis-in surveillance of tumor metastasis by liver natural killer cells
  
• Relationship between natural killer activity and anger expression in coronary heart disease
  
• Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
  
• IL-15 availability conditions homeostasis of peripheral natural killer T cells