T细胞活化

       大约20年前编码T细胞抗原受体的基因被识别，出现了关于这个蛋白质复合体的最初的描述。从那时起大量的进展是关于导致T细胞活化的中间过程的了解，这些过程是通过生化、细胞生物、遗传学、和影像方法获得的。这些试验的结果就是产生了T细胞活化的模型，在模型中确定了许多参与T细胞活化的成分。T细胞活化要求抗原受体、粘附分子和共刺激分子的相互作用。这些分子如何起作用以及它们之间的相互关系是现在研究的热点。在免疫反应中T淋巴细胞，作为直接效应细胞和调节身体防御功能的细胞，扮演着一个重要角色。正常的T细胞功能对于维持免疫系统内外的稳态是必需的。T细胞功能异常会导致免疫疾病，自身免疫病、过敏反应和免疫缺陷病。 为此CMBI特为大家准备了关于T细胞活化的特别报道，以供大家参考。更多文献敬请查阅CMBI的文献查询。

• T cell activation
  
• All roads lead to actin-the intimate relationship between TCR signaling and the cytoskeleton
  
• An architectural perspective on signaling by the pre-, and T cell receptors
  
• An evolutionary and structural perspective on T cell antigen receptor function
  
• GTPases and T cell activation
  
• Independent CD28 signaling via VAV and SLP-76
  
• Initiation of TCR signaling
  
• Initiation of TCR signaling-regulation within CD3 dimers
  
• JNK and p38 MAP kinases in CD4+ and CD8+ T cells
  
• Kinetic perspectives of T cell antigen receptor signaling.
  
• Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development
  
• Lipid phosphatases in the regulation of T cell activation
  
• Molecular and immunological basis of X-linked lymphoproliferative disease
  
• Molecular modifiers of T cell antigen receptor triggering threshold
  
• Negative feedback of T cell activation through inhibitory adapters and costimulatory receptors
  
• On the role of self-recognition in T cell responses to foreign antigen
  
• Protein kinase C-(PKC)-it's all about location, location, location
  
• Regulation of cytokine receptor signaling by SOCS1
  
• Role of protein tyrosine phosphatases in T cell activation
  
• Role of Shc in T-cell development and function
  
• Sin-good or bad-A T lymphocyte perspective
  
• T cell activation II-Signal integration
  
• T cell anergy and costimulation
  
• The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation
  
• The PI-3 kinase-Akt pathway and T cell activation
  
• The PKC gene module-molecular biosystematics to resolve its T cell functions
  
• The Ras-MAPK cascade and the control of positive selection
  
• The role of Tec family kinases in T cell development and function
  
• The roles of membrane microdomains (rafts) in T cell activation
  
• The TCR ADAPts to integrin-mediated cell adhesion
  
• The Wiskott-Aldrich syndrome protein-forging the link between actin and cell activation
  
• Transmembrane adapters-attractants for cytoplasmic effectors
  
• Vav1-a key signal transducer downstream of the TCR
  
• Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction
  
• Immune Mechanisms and Disease-Coordination of T Cell Activation and Migration through Formation of the Immunological Synapse
  
• T cell activation and enhanced apoptosis in non-ST elevation myocardial infarction
  
• A Novel ERK-dependent Signaling Process That Regulates Interleukin-2 Expression in a Late Phase of T Cell Activation
  
• The control of T cell activation vs
  
• Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation
  
• Positive and negative regulation of T cell activation through kinases and phosphatases
  
• Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
  
• Nitric oxide- a regulator of mast cell activation and mast cell-mediated inflammation
  
• Positive and negative regulation of T cell activation through kinases and phosphatases