抗病毒药物与呼吸系统感染
寻找有效的抗病毒药物和方法是控制和防治SARS的一个重要措施。为了促进防治SARS的研究，CMBI搜集了一些有关的文献，供研究人员参考。更多的文献资料，特别是抗HIV、肝炎病毒等其他非呼吸系统疾病病毒的药物，请访问CMBI的文献查询作进一步的了解。
综述
Antiviral Drugs GeneticVariability:The Key Problem in the Prevention andTherapy of RNA-BasedVirus Infections
drug design-STRATEGIES IN THE DESIGN OF ANTIVIRAL DRUGS drug-antiviral-Antiviral immunity drug-Antiviral-therapeutical approaches toward this strategic virus reservoir Nonsense-mediated mRNA decay in health and disease drug-antiviral-a Model System To Test Antiviral Gene Therapies drug-antiviral-An anti-idiotypic antibody with an internal image and human interferon--like antiviral activity drug-antiviral-Antiviral drugs-current state of the art drug-antiviral-Antiviral drugs-unapproved uses, dosages, or indications drug-antiviral-Contact dermatitis from topical antiviral drugs DRUG-Antiviral-The importance of specific virus diagnosis and monitoring for antiviral treatment drug-antiviral-Novel antiviral molecules drug-antiviral-Novel antiviral molecules2 drug-antiviral-Novel antiviral molecules-3 drug-antiviral-Novel antiviral molecules-4 inf-antiviral-Novel antiviral molecules-5 drug-antiviral-Structural Identification, Levels in Plasma, and Antiviral Activities drug-antiviral-The antiviral effects of nitric oxide drug-antiviral-The role of CC chemokine receptor 5 in antiviral immunity inf-antiviral-Influenza-virus-induced signaling cascades-targets for antiviral therapy inf-antiviral-Resistance to Macrolides and Related Antibiotics in Streptococcus pneumoniae inf-antiviral-The potential use of influenza virus as an agent for bioterrorism inf-antiviral-The role of antivirals in the control of influenza inf-antiviral-Viral suppression of systemic silencing inf-antiviral-Virus interception of cytokine-regulated pathways mp-The importance of specific virus diagnosis and monitoring for antiviral treatment
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疫苗
drug-antiviral-Gene vaccines drug-antiviral-Hydrodynamic injection of viral DNA drug-antiviral-VACCINES AND ANTIVIRAL AGENTS vaccine-Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways respir-respiratory medicine-PNEUMOCOCCAL AND INFLUENZA VACCINATION Pediatric-Respiratory syncytial virus vaccine development Association Between Influenza Vaccination and Reduced Risk of Brain Infarction Association of Influenza Vaccination and Reduced Risk of Recurrent Myocardial Infarction cv-imm-Association Between Influenza Vaccination and Reduced Risk of Brain Infarction Immunoadjuvant activity of interferon-γ-liposomes co-administered with influenza vaccines inf-A novel bioadhesive intranasal delivery system for inactivated influenza vaccines inf-Influenza vaccination for healthy children inf-Influenza vaccination in old age Intranasal immunization with inactivated influenza vaccine Medical Progress-Is It Time to Give Influenza Vaccine to Healthy Infants medicine-Evidence-Based-inactivated vaccines provide the greatest protection against influenza in healthy people pediatric infectious diseases-Cold-adapted influenza vaccines public healthConsiderations for adding pneumonia and influenza vaccines to public health programmes respir-respiratory medicine-PNEUMOCOCCAL AND INFLUENZA VACCINATION The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus,Implications for peptide vaccination vaccine-Influenza virosomes vaccine-Novel approaches in the development of immunopotentiating reconstituted influenza virosomes vaccines-Influenza vaccines-present and future
呼吸系统抗病毒
drug-antiviral-A cotton rat model of human parainfluenze 3 laryngotracheitis-Virus growth, pathology, and therapy drug-antiviral-Antiviral agents against respiratory viruses drug-antiviral-Antiviral drugs-Treatment of influenza and respiratory syncytial virus infections drug-antiviral-The treatment of influenza with antiviral drugs drug-antiviral-Beta-cyclodextrin de-to enhance antiviral activity of an antisense oligonucleotide directed-a coronavirus drug-antiviral-Cost burden of viral respiratory infections drug-antiviral-Cost-effectiveness of newer treatment strategies for influenza drug-antiviral-Decision analysis of empirical antiviral treatment of influenza virus infection versus treatment based on rapid test results drug-antiviral-Defective influenza A virus generated entirely from plasmids-its RNA is expressed in infected mouse lung and modulates disease drug-antiviral-Development of a novel influenza A antiviral assay respir-ARDS.ALI-Respirable antisense oligonucleotides-a new drug class for respiratory disease inf-coronavirus-a database of virus-specific oligonucleotides drug-antiviral-Evaluation of a rapid test (QuickVue) compared with the shell vial assay for detection of influenza virus clearance after antiviral treatment drug-antiviral-Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus drug-antiviral-Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes drug-antiviral-Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses drug-antiviral-Influenza-virus-induced signaling cascades-targets for antiviral therapy drug-antiviral-Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression drug-antiviral-Nosocomial pneumonia drug-antiviral-Optimization of in situ cellular ELISA performed on influenza A virus-infected monolayers for screening of antiviral agents drug-antiviral-Rapid and sensitive detection of respiratory virus infections for directed antiviral treatment using R-Mix cultures drug-antiviral-Reduction of the influenza burden in children drug-antiviral-Respiratory consequences of rhinovirus infection drug-antiviral-The common cold drug-antiviral-The treatment of influenza with antiviral drugs drug-antiviral-Viral respiratory infection therapy drug-antiviral-Viral respiratory infections in association with asthma and sinusitis inf-SARS-The treatment of influenza with antiviral drugs respir-ARDS.ALI-Antibiotic therapy of community respiratory tract infections respir-ARDS.ALI-viral respiratory infections-Viral respiratory infection therapy respir-Influenza-Will New Diagnostic Tests and Antiviral Drugs Make a Difference DRUG-Antiviral-Current research on respiratory viral infections
非特异性免疫
drug-antiviral-Mycophenolate mofetil-New applications for this immunosuppressant drug-antiviral-NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus drug-antiviral-Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT-1 and NF-B) complexes by antibody-dependent enhancement of macrophage infection inf-Human cytomegalovirus terminase as a target for antiviral chemotherapy drug-antiviral-Cytotoxic T lymphocytes, chemokines and antiviral immunity drug-Antiviral-Synthesis, cytotoxicity and antiviral activity of N,N'-bis-5-nitropyrimidyl derivatives of dispirotripiperazine drug-antiviral-Antiviral Actions of Interferons drug-antiviral-c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity drug-antiviral-Cyclin-dependent kinases as cellular targets for antiviral drugs drug-antiviral-Improving Nucleoside Diphosphate Kinase for Antiviral Nucleotide Analogs Activation drug-antiviral-Inhibition of Cyclin-Dependent Kinase 1 by Purines-with Antiviral Activity drug-antiviral-Interferon-Induced Mx Proteins-Dynamin-Like GTPases with Antiviral Activity drug-antiviral-Interferons and their application in the diseases of the lung drug-antiviral-ISG20, a new interferon-defines an alternative antiviral pathway against RNA genomic viruses drug-antiviral-Pokeweed antiviral protein-a potential nonspermicidal prophylactic antiviral agent drug-antiviral-Severe acute interstital pneumonia and gefitinib drug-antiviral-The Antiviral Response to Gamma Interferon drug-antiviral-The virus battles-IFN induction of the antiviral state and mechanisms of viral evasion drug-antiviral-Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication inf-Balancing Selection at the Prion Protein Gene Consistent with Prehistoric Kurulike Epidemics ck-IFN induction of the antiviral state and mechanisms of viral evasion ck-IFN-s mediate antiviral protection through a distinct class II cytokine receptor complex ck-Cytokine receptors, signaling pathways and viruses-IFN induction of the antiviral state and mechanisms ck-The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors therapy-Protein-protein interactions as targets for antiviral chemotherapy inf-The interferon antiviral response-from viral invasion to evasion drug-antiviral-Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates drug-antiviral-Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors drug-antiviral-Enantioselectivity of the antiviral effects of nucleoside analogues drug-antiviral-Immunomodulatory antivirals. Antiviral activity of nucleoside derivatives
抗病毒药物
drug-antiviral-Separation methods for tricyclic antiviral drugs drug-antiviral-Separation methods for acyclovir and related antiviral compounds drug-antiviral-Separation methods for antiviral phosphorus-containing drugs drug-antiviral-Synthesis and antiviral activity evaluation of novel 2-phenyl-4-(d-arabino-4′-cycloaminobutyl)triazoles drug-antiviral-Synthesis and antiviral activity of acyclovir-5′-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug drug-antiviral-Synthesis and Antiviral Activity of Cyclohexenyl Nucleosides drug-antiviral-Synthesis and antiviral activity of novel d-and l-2′-azido-2′,3′-dideoxyribofuranosyl-4′-thiopyrimidines and purines drug-antiviral-Synthesis and antiviral evaluation of nucleic acid-based (NABTM) libraries drug-antiviral-Synthesis and antiviral-antiproliferative activity of some N-sulphonylbenzimidazoles drug-antiviral-Synthesis of 2′, 3′-dideoxy-3′-C-(hydroxymethyl)-4′-thiopentofuranosyl nucleosides as potential antiviral agent drug-antiviral-Synthesis of novel (2R,4R)-and (2S,4S)-iso dideoxynucleosides with exocyclic methylene as potential antiviral agents drug-antiviral-Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies drug-antiviral-Virogenomics-a novel approach to antiviral drug discovery drug-antiviral-Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents drug-antiviral-Antiviral activity of cyclopentenyl nucleosides against orthopox viruses drug-antiviral-drug-antiviral-5-Bromo (or chloro)-6-azido-5,6-dihydro-2′-deoxyuridine and-thymidine derivatives with potent antiviral activity drug-antiviral-Heterocyclic nucleoside analogues-design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles drug-antiviral-Molecular Modeling Approach to Understanding the Mode of Action of L-Nucleosides as Antiviral Agents drug-antiviral-Synthesis and antiviral activities of N-9-oxypurine 1,3-Dioxolane and 1,3-oxathiolane nucleosides Genetic risks of antiviral nucleoside analogues drug-Antiviral-2-chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections therapy-patent-Novel therapeutic strategies for sulfonamide derivativ as anticancer, anti-inflammatory and antiviral-patent mol med-inf-Ribavirin's antiviral mechanism of action-lethal mutagenesis medicine-drug-An attempt to predict a possible existence of antiviral and antimicrobial activity drug-Antiviral-Antiadenovirus activity of milk protein-lactoferrin prevents viral infection DRUG-Antiviral-Antiviral activities of lactoferrin drug-Antiviral-Characterizing antiviral activity of adefovir dipivoxil drug-Antiviral-Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent drug-Antiviral-Synthesis of new 3-methylthio-5-aryl-4-isothiazolecarbonitriles with broad antiviral spectrum
核酸药物
drug-antiviral-RNA interference-a promising approach to antiviral therapy drug-antiviral-RNAi is successful as an antiviral in proof of principle experiments RNAi-RNA interference-antiviral defense and genetic tool RNAi-Targeting an Animal Virus-News from the Front RNAi-Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs RNAi-Interference of hepatitis C virus RNA replication by short interfering RNAs RNAi-lentivirus-based system to functionally silence genes in mammalian cells, stem cells by RNA interference RNAi-RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription RNAi-Lentivirus-delivered stable gene silencing by RNAi in primary cells RNAi-Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells RNAi-RNA Interference-A New Weapon against HIV and Beyond RNAi-RNA Interference-A New Weapon against HIV and Beyond-fig1 RNAi-RNA Interference-A New Weapon against HIV and Beyond-fig2 RNAi-RNA Interference-A New Weapon against HIV and Beyond-tab1 RNAi-RNA Interference - A New Weapon against HIV and Beyond RNAi-RNA interference of HIV replication RNAi-Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 RNAi-hiv-Choosing CCR5 or Rev siRNA in HIV-1RNAi-Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs RNAi-hepatitis-RNA interference targeting Fas protects mice from fulminant hepatitis RNAi-hepatitis-siRNAs knock down hepatitis RNAi-RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells gt-RNA-Based Anti-HIV-1 Gene Therapeutic Constructs in SCID-hu Mouse Model gt-Gene therapy for liver diseases-recent strategies for treatment of viral hepatitis and liver malignancies gt-inf-Inhibition of HIV-1 replication by novel lentiviral vectors-Rev and HIV-1 env antisense gt-Antisense therapy of influenza respir-Respirable antisense oligonucleotides-a new drug class for respiratory disease Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis drug antisense-Efficiency of Antisense Oligonucleotide Drug Discovery
天然药物
drug-antiviral-Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge drug-antiviral-Antiviral activity of an acidic polysaccharides fraction extracted from Cedrela tubiflora leaves drug-antiviral-Antiviral activity of Bolivian plant extracts drug-antiviral-Antiviral and antimicrobial activities of Colombian medicinal plants drug-antiviral-Antiviral and cytotoxic activities of some Indonesian plants drug-antiviral-Antiviral Chinese medicinal herbs against respiratory syncytial virus drug-antiviral-Evaluation of the antiviral activity of an aqueous extract from Phyllanthus orbicularis drug-antiviral-Further evaluation of Rwandan medicinal plant extracts for their antimicrobial and antiviral activities drug-antiviral-In vitro antiviral activity of thirty-six plants from La Réunion Island drug-antiviral-Screening of Australian medicinal plants for antiviral activity drug-antiviral-Screening of Nepalese medicinal plants for antiviral activity drug-Antiviral-Antiviral activity of Plantago major extracts and related compounds
其他
drug-antiviral-Antiviral drug design-Computational Analyses of the Effects of the L100I Mutation for HIV-RT on the Binding of NNRTIs drug-antiviral-Antiviral Effects of Pyrrolidine Dithiocarbamate on Human Rhinoviruses drug-antiviral-Application of Real-Time PCR for Determination of Antiviral Drug Susceptibility of Herpes Simplex Virus drug-antiviral-Hepatitis C-molecular virology and antiviral targets drug-antiviral-New anti-HIV derivatives-synthesis and antiviral evaluation drug-antiviral-Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors drug-antiviral-Short constrained peptides that inhibit HIV-1 entry inf-antiviral-In vitro activity of potential anti-poxvirus agents inf-antiviral-Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus inf-antiviral-Therapy and short-term prophylaxis of poxvirus infections DRUG-Antiviral International Symposium on Viral Hepatitis mol med-inf-Inhibition of duck hepatitis B virus replication by intrahepatic expression of an antiviral resistance gene drug-Antiviral-Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease drug-Antiviral-Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides drug-Antiviral-Hepatitis B treatment DRUG-Antiviral-HIV fusion and its inhibition drug-Antiviral-Identification of active antiviral compounds against a New York isolate of West Nile virus DRUG-Antiviral-Immunopathogenesis of hepatitis B e antigen negative chronic hepatitis B infection DRUG-Antiviral-Inhibition of cytomegalovirus immediate early gene expression-a therapeutic option drug-Antiviral-Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound drug-Antiviral-Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug drug-Antiviral-Treatment of picornavirus infections drug-Antiviral-Treatment comparisons in HIV infection drug-Antiviral-Nucleotide triphosphatase-helicase of hepatitis C virus as a target for antiviral therapy DRUG-Antiviral-Novel cell culture systems for the hepatitis C virus drug-Antiviral-Magnitude and quality of antibody response to a combination hepatitis A and hepatitis B vaccine drug-Antiviral-Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza drug-Antiviral-Lamivudine resistance in hepatitis B-mechanisms and clinical implications drug-Antiviral-Anti-HIV activity of a novel aminoglycoside-arginine conjugate drug-Antiviral-Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses drug-Antiviral-Evidence of dual sites of action of dendrimers-SPL-2999 inhibits both virus entry and late stages of herpes simplex virus replication drug-Antiviral-Experimental therapy of filovirus infections drug-Antiviral-Goals and milestones during treatment of HIV-1 infection with antiretroviral therapy drug-Antiviral-Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn drug-antiviral-HCV RNA-dependent RNA polymerase as a target for antiviral development
