Autoimmunity



自身免疫( Autoimmunity)
自身免疫是机体免疫系统对自身成分发生免疫应答的现象。机体对外来抗原免疫应答的结局通常是清除抗原，而对自身成分发生免疫应答时，自身的细胞或组织不易被免疫系统的效应细胞完全清除而是不断地受到攻击，结果使机体进入疾病状态，称自身免疫病。已经有80种以上与自身免疫有关的疾病，从一些发病率相对较高的自身免疫性甲状腺病，到威胁生命的系统性红斑狼疮。目前，对于自身免疫的研究主要围绕自身免疫病展开，涉及各种自身免疫疾病机制和可能的治疗、预防方法。过去半个世纪的研究理解了免疫自身、自身与非自身的识别，以及正常自身耐受的机制，清晰了解从对自身成分无反应到自身免疫病的一系列事件。随着对决定免疫反应强弱的宿主遗传特点的进一步了解，识别出那些高敏感性的个例，有可能出现良性的抗原特异性干预法，从而为有效地预防自身免疫病带来光明的未来。 CMBI为大家准备了关于自身免疫的特别报道，以供参考。更多文献敬请查阅CMBI的文献查询。
Autoimmunity at a turning point-from investigation to intervention Conditional autoimmunity mediated by human natural anti-FcRI autoantibodies Neutrophil-specific autoantibodies in chronic inflammatory bowel diseases Autoimmune sensorineural hearing loss 10th International Congress on antiphospholipid antibodies Anti-neutrophil cytoplasmic antibodies and pathogenesis of small vessel vasculitides Antiphospholipid syndrome- pathogenic mechanisms Antiphospholipid syndrome Apoptosis and the liver- relation to autoimmunity and related conditions Application of tetramer technology in studies on autoimmune diseases B lymphocytes contribute to autoimmune disease pathogenesis Chemical-specific properties co-determine the type of adverse immune response Chronic urticaria and autoimmune thyroid disease Cryptic infection and autoimmunity Dosage and characterization of circulating DNA From proteomics to molecular epidemiology Liver transplantation for primary biliary cirrhosis MHC class II peptide flanking residues of exogenous antigens influence recognition by autoreactive T cells Microchimerism in autoimmune disease Modifications of arginines and their role in autoimmunity New insights into the pathogenesis of systemic sclerosis T cell immunity and primary biliary cirrhosis The antiphospholipid syndrome The control of T cell activation vs The epidemiology of autoimmune diseases The role of iron in T cell development and autoimmunity Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease Neutralizing interferon alpha as a therapeutic approach to autoimmune diseases Role of inherited defects decreasing Fas function in autoimmunity Suppression of experimental autoimmune encephalomyelitis Autoantibody-induced apoptosis as a possible mechanism of autoimmune retinopathy Autoantibody-mediated atherosclerosis Improving the effectiveness of autoantibody testing in the clinic New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis Autoantibodies to factor VIII with catalytic activity Autoantibodies to ion channels at the neuromuscular junction Anti-chromatin (anti-nucleosome) autoantibodies Autoantibodies to factor VIII Autoantibodies to heparan sulfate proteoglycans Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1-deficient chimeric mice About CD4pos CD25pos regulatory cells Accelerated atherogenesis in autoimmune rheumatic diseases Adoptive cellular gene therapy of autoimmune disease Adoptive Transfer Enables Tumor Rejection Targeted against a Self-Antigen Antiendothelial cell antibodies in systemic lupus erythematosus Antigen-Specific Mediated Suppression of Cell Autoimmunity by Plasmid DNA Vaccination Antimitochondrial antibodies in primary biliary cirrhosis Autoimmune Diseases Autoimmunity Against the Second Extracellular Loop of β1-Adrenergic Receptors Induces β-Adrenergic Receptor Desensitization and Myocardial Hypertrophy In Vivo Autoimmunity, oxidized LDL and cardiovascular disease Autoimmunization to Epidermal Growth Factor, a component of the immunological homunculus Autologous hematopoietic stem cell transplantation for Crohn's disease Autoreactive T cell responses in pemphigus and pemphigoid B cell receptor signaling and autoimmunity Cancer and autoimmunity Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes Cardiac Myosin Autoimmunity in Acute Chagas' Heart Disease Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity CD40L in autoimmunity and mucosally induced tolerance CD8+ T suppressor cells are back to the game- are they players in autoimmunity Chemokines in autoimmunity- from pathology to therapeutics Chronic Gastritis Patients to Helicobacter pylori-Mediated Autoimmunity Clinical relevance of antiprothrombin antibodies COMPLEXITIES OF CD28-B7- CTLA-4 COSTIMULATORY PATHWAYS IN AUTOIMMUNITY AND TRANSPLANTATION Cytomegalovirus in autoimmunity Do NKT cells control autoimmunity Ectopic Lymphoid Organogenesis - A Fast Track for Autoimmunity Endothelium as a target for anti-phospholipid antibodies and for therapeutical intervention Epitope spreading and molecular mimicry as triggers of autoimmunity in the Theiler's virus-induced demyelinating disease model of multiple sclerosis Evidence of Autoimmunity in Male Twins With Neonatal Diabetes Genetic dissection of familial autoimmune thyroid diseases using whole genome screening Hematopoietic stem cell therapy for type 1 diabetes- induction of tolerance and islet cell neogenesis Heparin-induced thrombocytopenia with thrombotic sequelae High-density lipoprotein-associated apolipoprotein A-I- the missing link between infection and chronic inflammation HIV and autoimmunity Hughes syndrome crosses boundaries Immunglobulin repertoire analysis provides new insights into the immunopathogenesis of Sjogren's syndrome Immunologic Issues in Type 1 Diabetes Immunomodulation for treatment and prevention of atherosclerosis Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis In Vivo Neutralization of TNF- Promotes Humoral Autoimmunity by Preventing the Induction of CTL Inducible and Reversible β-Cell Autoimmunity and Hyperplasia in Transgenic Mice Expressing a Conditional Oncogene Insulin autoimmunity-prediction-precipitation-prevention type 1A diabetes Iodine- an environmental trigger of thyroiditis Is peripartum cardiomyopathy an organ-specific autoimmune disease Lack of Coreceptor Allows Survival of Stimulated Double-negative T Cells for Autoimmunity Ligand for the Chemokine Receptor CCR7 Can Influence the Homeostatic Proliferation of CD4 T Cells and Progression of Autoimmunity Long-Term Outcome of Interferon--Induced Thyroid Autoimmunity Mechanisms for the induction of autoimmunity by infectious agents Neuroprotective autoimmunity autoimmunity-Prospective study of enteroviral infections and development of beta-cell autoimmunity Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype- effect of multiple gene interactions Pathogenesis of heparin-induced thrombocytopenia and thrombosis Pathogenic effects of anti-Fc gamma receptor IIIb (CD16) on polymorphonuclear neutrophils in non-organ-specific autoimmune diseases Pregnancy outcome in systemic lupus erythematosus Primary biliary cirrhosis and hepatocellular carcinoma Prolactin and autoimmunity Protective Autoimmunity Is a Physiological Response to CNS Trauma Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor Induce Antigen-specific Protection of Mice from Autoimmunity Resistance to Xenobiotic-Induced Autoimmunity Maps to Chromosome 1 Rheumatic fever- the T cell response leading to autoimmune aggression in the heart Role of Cyclin Kinase Inhibitor p21 in Systemic Autoimmunity Role of profibrogenic cytokines secreted by T cells in fibrotic processes in scleroderma Sex hormones and rheumatoid arthritis Sex ratio and rheumatic disease T cell homeostasis and systemic autoimmunity T cell homeostatic proliferation elicits effective antitumor autoimmunity targets of nephritogenic antibodies in systemic autoimmune disorders Th2-type immunopathological manifestations induced by mercury chloride or gold salts The clearance of apoptotic cells- implications for autoimmunity The pathogenesis of inflammatory muscle diseases The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT Thyroid autoimmunity Thyroid Function and Autoimmunity during Interferon β-1b Treatment Tolerance and autoimmunity Transgenic Expression of Granulocyte Macrophage-Colony Stimulating Factor Initiates Autoimmunity Transplantation Tolerance and Autoimmunity After Xenogeneic Thymus Transplantation Treatment of pregnancy loss in Hughes syndrome Viral etiopathogenesis of Sjogren's syndrome Characterization of Regulatory Elements and Methylation Pattern of the Autoimmune Regulator (AIRE) Promoter Rituximab therapy and autoimmune disorders- Prospects for anti-B cell therapy myocarditis-Amiodarone minimizes experimental autoimmune myocarditis Celiac Disease-a model autoimmune disease with gene therapy applications Gene therapy in autoimmune, demyelinating disease of the central nervous system Vectors for the treatment of autoimmune disease spectrum of autoimmune autonomic neuropathies Neuroimmunomodulation-Neuroendocrine and Neural Factors in Autoimmune, Inflammatory, Infectious, and Allergic Disease Neuroimmunomodulation-Sympathetic Abnormalities during Autoimmune Processes- Potential Relevance of Noradrenaline-Induced Apoptosis glomerulonephritis-Chemokines- therapeutic targets for autoimmune and inflammatory renal disease Identification Of The Cell Antigen Targeted By A Prevalent Population Of Pathogenic Cd8+ T Cells In Autoimmune Diabetes The Myelin Basic Protein-Reactive T Cell Receptor V Repertoire During Experimental Autoimmune Encephalomyelitis Immune Mechanisms and Disease-Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune-Prone MRL Immune Mechanisms and Disease-CD137-Mediated T Cell Co-Stimulation Terminates Existing Autoimmune Disease in SLE-Prone NZB-NZW F1 Mice Immune Mechanisms and Disease-Tolerogenic Dendritic Cells Induced by Vitamin D Receptor Ligands Enhance Regulatory T Cells Inhibiting Autoimmune Diabetes Cytokine-based immunointervention in the treatment of autoimmune diseases diabetes-glutamic acid decarboxylase (GAD) self peptides in NOD mice autoimmune diabetes molecular med-Pathogenesis of endometriosis-natural immunity dysfunction or autoimmune disease Cytokine-based immunointervention in the treatment of autoimmune diseases Autoimmunity to Gastrointestinal Endocrine Cells in Autoimmune Polyendocrine Syndrome Type I Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-- mice Regulatory lymphocytes-JANUS-LIKE ROLE OF REGULATORY INKT CELLS IN AUTOIMMUNE DISEASE AND TUMOUR IMMUNITY Antigen presentation by keratinocytes directs autoimmune skin disease Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease Autonomic myasthenia- the case for an autoimmune pathogenesis Alternative Core Promoters Regulate Tissue-specific Transcription from the Autoimmune Diabetes-related ICA1 (ICA69) Gene Locus Peripartum cardiomyopathy- a selenium disconnection and an autoimmune connection The Genetics of Autoimmune Thyroid Disease Transgenic models of autoimmune disease Harm or heal – divergent effects of autoimmune neuroinflammation Interleukin-6-Deficient Mice Resist Development of Autoimmune Myocarditis Associated Is peripartum cardiomyopathy an organ-specific autoimmune disease the T cell response leading to autoimmune aggression in the heart Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

Last Modified: 2003-11-02