Fifteen Years Of Endothelin Research



内皮素研究15年
自从1988年日本科学家Yanagisawa发现内皮素以来，至今已逾15年的历史，作为一个心血管的明星分子和重要生物活性多肽，目前积累的文献已逾15205篇，它不仅涉及内皮素的合成、代谢、降解、分布、功能和生理作用，而且在心血管疾病中亦具有十分重要的意义。它是继血管紧张素以后的一个最重要的活性多肽。近年来内皮素受体拮抗剂的出现和临床应用，又为内皮素的基础和临床研究注入了新的活力。此外内皮素还在肿瘤、呼吸系统、肾病、糖尿病、和心源性、败血性、出血性休克等疾病中具有重要的病理生理意义。鉴于内皮素研究的重要性，CMBI特将最新的关于内皮素研究的文献集结成辑，供研究参考。更多文献敬请查阅CMBI的文献查询。
The Endothelin System In Pulmonary Hypertension The Endothelin System And Its Role In Acute Myocardial Infarction Synthesis And Degradation Of Endothelin-1 Sarcolemma And Nuclear Membranes Et-1 Regulates Transcellular Calcium Levels In Heart And Vsmc Role Of Et-1 In The Regulation Of Coronary Circulation Role Of Endothelins In Septic, Cardiogenic, And Hemorrhagic Shock Role Of Endothelins In Congestive Heart Failure Role Of Endothelins In Animal Models Of Hypertension-Focus On Cardiovascular Protection Role Of Endothelin In Regulation Of Resistance, Fluid-Exchange,Functions Of The Systemic Circulation Role Of Endothelin In Human Hypertension Fifteen Years Of Endothelin Research-Preface Modulation And Roles Of The Endothelins In The Pathophysiology Of Pulmonary Embolism Endothelins In Chronic Diabetic Complications Endothelin-1 In Chronic Renal Failure And Hypertension Endothelin-1 In Atherosclerosis And Other Vasculopathies Endothelin In The Perinatal Circulation Cv-Et-1-And No-Mediated Signal Transduction Pathway In Human Brain Capillary Endothelial Cells Sr141716a-Sensitive Enhancement Of Et-1 Hypotensive Effect By Chronic Nos Inhibition Role Of Reactive Oxygen Species In Endothelin-Induced Hypertension Physiology And Pathology Of Endothelin-1 In Renal Mesangium Gene Expression Profile Of Endothelin-1-Induced Growth In Glomerular Mesangial Cells Functional Endothelin Receptors Are Present On Nuclei In Cardiac Ventricular Myocytes Eyeing Endothelins-A Cellular Perspective Eta Receptor Blockade Decreases Vascular Superoxide Generation In Doca-Salt Hypertension Et-1 Increases Distensibility Of Acutely Loaded Myocardium-A Novel Eta And Na+-H+ Exchanger- Endothelin-Receptor Deficiency Predisposes To Pulmonary Edema Formation Via Increased Lung Vascular Endothelial Cell Growth Factor Expression Endothelin-Converting Enzyme-1 (Ece-1) Is A Downstream Target Of The Homeobox Transcription Factor Nkx2-5 Endothelin-A Receptors Mediate Renal Hemodynamic Effects Of Exogenous Angiotensin Ii In Humans Endothelin-1 Concentration In Plasma Is Increased After Jogging But Decreased After Cycling In Healthy Men Endothelin Receptor Antagonists In Cardiology Clinical Trials Endothelin In Neurohormonal Activation In Heart Failure Endothelin Eta Receptor Antagonism Does Not Attenuate Angiotensin Ii-Induced Cardiac Hypertrophy In Vivo Elastase-Induced Suppression Of Endothelin-Mediated Ca2+ Entry Mechanisms Of Vascular Contraction Drug-Development Of Endothelin Receptor Antagonists As Potential Therapeutic Agents Diabetes-Induced Overexpression Of Endothelin-1 And Endothelin Receptors In The Rat Renal Cortex Acute Endothelin-Receptor Antagonism Improves Pulmonary And Systemic Haemodynamics In Patients With Pulmonary Arterial Hypertension Therapeutic Potential Of Endothelin-1 Receptor Antagonists And Endothelin-Converting Enzyme Inhibitors Endothelin-1--Multifunctional Molecule In Cancer Endothelins And Coronary Vascular Biology As-Endothelin, Hypercholesterolemia And Atherosclerosis Endothelin-1 And Vascular Tone In Subjects With Atherogenic Risk Factors Nephroprotective effects of the endothelin ETA receptor antagonist darusentan in salt-sensitive genetic hypertension Functional significance of protein kinase A activation by endothelin-1 and ATP Endothelin-1 directly modulates its own secretion Endothelin Receptor Blockade and Exacerbation of Heart Failure Endothelin ETA but not ETB receptors mediate contraction of common bile duct Antiapoptotic Effect of Endothelin-1 in Rat Cardiomyocytes In Vitro NEW VIEWS ON THE ROLE OF ENDOTHELIN Characterization of Endothelin-converting Enzyme-2 Characterization of Endothelin-converting Enzyme-2 Vasopressin Induces Vascular Superoxide Via Endothelin-1 in Mineralocorticoid Hypertension Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress Increased endothelin-1 expression in the kidney in hypercalcemic rats Gender Differences in ET and NOS Systems in ETB Receptor-Deficient Rats ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and Endothelin-Induced Increases in Ca2+ Entry Mechanisms of Vascular Contraction Are Enhanced During High-Salt Endothelin Inhibits NPR-A and Stimulates eNOS Gene Expression in Rat IMCD Cells Endothelin-1 Increases Vascular Superoxide via EndothelinA-NADPH Oxidase Pathway in Hypertension Endothelin Antagonism and the Failing Heart Endothelin B receptor gene hypermethylation in prostate adenocarcinoma Emerging role of endothelin-1 in tumor angiogenesis The First Inner Loop of Endothelin Receptor Type B Is Necessary for Specific Coupling to G13 Endothelin-1 induced proinflammatory markers in the myocardium and leukocytes of guinea-pigs Endothelin receptor blockade lowers plasma aldosterone levels via different mechanisms in primary aldosteronism Alzheimer's Disease-Amyloid Peptide Is Increased in Mice Deficient in Endothelin-converting Enzyme Relaxin, a Pregnancy Hormone, Is a Functional Endothelin-1 Antagonist Emerging role of endothelin-1 in tumor angiogenesis Heterodimerization of Endothelin-converting Enzyme-1 Isoforms Regulates the Subcellular Distribution of This Metalloprotease Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II-Induced Cardiac Damage NEW THERAPEUTICS THAT ANTAGONIZE ENDOTHELIN-PROMISES AND FRUSTRATIONS Concentration of circulating plasma endothelin in patients with angina and normal coronary angiograms Function of the endothelinB receptor in cardiovascular physiology and pathophysiology Expression of endothelins in human cardiogenesis Endothelin B receptor gene hypermethylation in prostate adenocarcinoma drug-Therapeutic Potential for Endothelin Receptor Antagonists in Cardiovascular Disorders Coronary reactivity to endothelin-1 during partial ischemia Celiprolol inhibits mitogen-activated protein kinase and endothelin-1 and transforming growth factor-\|?1 gene in rats Concentration of circulating plasma endothelin in patients with angina and normal coronary angiograms The Extracellular N Terminus of the Endothelin B (ETB) Receptor Is Cleaved by a Metalloprotease in an Agonist-dependent Process Stress-activated protein kinase-c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis Sources of endothelin-1 in hippocampus and cortex following traumatic brain injury Constitutive Phosphorylation of Human Endothelin-converting Enzyme-1 Isoforms Antioxidants inhibit endothelin-1 (1–31)-induced proliferation of vascular smooth muscle cells Analysis of the time course for organ culture-induced endothelin ETB receptor upregulation in rat mesenteric arteries Heart Failure ETA Receptor Blockade Trial Involvement of Endogenous Endothelin-1 in Exercise-Induced Redistribution of Tissue Blood Flow Selective Upregulation of Endothelin B Receptor Gene Expression in Severe Pulmonary Hypertension Role of endothelin-1 in a cirrhotic rat model with endotoxin induced acute renal failure Role of endothelin ETB receptors in the renal hemodynamic and excretory responses to big endothelin-1 Renal protective effect of YM598, a selective endothelin ETA receptor antagonist Preproendothelin-1 Gene Polymorphism Is Related to a Change in Vascular Reactivity Plasma endothelin in patients with acute aortic disease Pharmacological possibilities for protection against myocardial reperfusion injury Peptides acting at gap junctions Leptin Induces Endothelin-1 in Endothelial Cells Increased Activity of Endogenous Endothelin in Patients With Type II Diabetes Mellitus Hydrogen peroxide regulation of bovine endothelin-converting enzyme-1 Function of the endothelinB receptor in cardiovascular physiology and pathophysiology Function and Regulation of Endothelin-1 and Its Receptors in Salt Sensitive Hypertension Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis Endothelium-derived mediators and hypoxic pulmonary vasoconstriction Endothelin-1-Induced Enhancement of Coronary Smooth Muscle Contraction via MAPK-Dependent Endothelin suppresses cell migration via the JNK signaling pathway Endothelin receptors Endothelin Mediates Increased Pulmonary Vascular Tone in Patients With Heart Failure Endothelin is an important determinant of renal function Endothelin in the mechanism of endothelial injury and neutrophil adhesion in the post-ischemic guinea-pig heart Endothelin Blockade on Basal and Stimulated Forearm Blood Flow in Patients With Essential Hypertension Endothelin A-receptor antagonist administration immediately after experimental myocardial infarction Endothelin Antagonism and Interleukin-6 Inhibition Attenuate Effects of C-Reactive Protein Endothelial responses to mechanical stress Endothelial cell dynamics and complexity theory Effects of cerebrovascular challenges on plasma endothelin Effect of Ro 61-1790, a selective endothelin-A receptor antagonist Cortical expression of endothelin receptor subtypes A and B following middle cerebral artery occlusion Complete results of the first randomized, placebo-controlled study of bosentan, a dual endothelin receptor antagonist, in pulmonary arterial hypertension Combined Endothelin Receptor Blockade Evokes Enhanced Vasodilatation in Patients With Atherosclerosis Collagen accumulation after myocardial infarction-effects of ETA receptor blockade and implications for early remodeling Chronic ETA receptor blockade prevents endothelial dysfunction of small arteries Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention Bosentan, a dual endothelin receptor antagonist Biphenylsulfonamide Endothelin Receptor Antagonists bioactive peptide endothelin causes multiple biologic responses Autocrine Stimulation of Cardiac Na+-Ca2+ Exchanger Currents by Endogenous Endothelin advances in endothelin research and first antagonist gains FDA approval Activation of the cardiac endothelin system in left ventricular hypertrophy Activated Mast Cells Increase the Level of Endothelin-1 mRNA in Cocultured Endothelial Cells A role for endothelin receptor blockade in improving the endothelial function of coronary artery grafts Vascular Remodeling After Injury Revealed by Endothelin-B Receptor-Knockout Mice Mechanism of endothelin-1-induced cytosolic Ca2+ mobility in cultured H9c2 myocardiac ventricular cells Endothelin 1 Type A Receptor Antagonism Prevents Vascular Dysfunction Diabetes-Induced Renal Overexpression of Endothelin-1 and Endothelin A and B Receptors Clinical Efficacy of Sitaxsentan, an Endothelin-A Receptor Antagonist Association Between Plasma Endothelin-1 Levels and Cheyne-Stokes Respiration in Patients With Congestive Heart Failure

Last Modified: 2003-12-22