高血压的最新发展

   据WHO最新统计,世界上平均每8个死亡病例中就有一个是死于高血压,高血压已攀居世界疾病的第三大杀手。预防、观察、评估和治疗高血压国家联合委员会的第七次报告(The JNC 7 report)--将于2003年5月21日刊登在JAMA的第19期上--重点讨论了怎样才能控制高血压的发生,这其中收缩压的控制是治疗的关键,收缩压达到115mmHg、舒张压达到75mmHg就有发生心血管疾病的危险。年龄在55岁、血压在正常范围的老年人有90%的可能在未来的25年中患有高血压,而如果血压偏低但正朝着正常范围(120/80mmHg)发展的老年人,他患心脏病、心衰、中风及肾脏疾病的几率会很低。报告还同时讨论了治疗高血压的新方案。为此以这篇文章为中心,Cmbi搜集了近一年发表的高血压的报道和文献,奉献给大家。更多的文献查询请访问CMBI的文献查询作进一步的了解。

Hypertension Treatment Guidelines
It's More Than High Blood Pressure
Hypertension Prevalence and Blood Pressure Levels in 6 European Countries, Canada, and the United States
 

  • Altered Renal Handling of Sodium in Human Hypertension

  • An Acyl-CoA Synthetase Gene Family in Chromosome 16p12 May Contribute to Multiple Risk Factors

  • Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

  • Antioxidant Activities and Oxidative Stress Byproducts in Human Hypertension

  • Associations Between Hypertension and Genes in the Renin-Angiotensin System

  • Hypotension and Reduced Catecholamines in Neuropeptide Y Transgenic Rats

  • Interactions Between Leptin and the Human Sympathetic Nervous System

  • Is Altered Adrenal Steroid Biosynthesis a Key Intermediate Phenotype in Hypertension

  • Membrane Microdomains and Vascular Biology

  • New pacing technologies for heart failure

  • Prediction of Genetic Risk for Hypertension

  • Racial Differences in the Prevalence of Hypertensive Retinopathy

  • Review of the Adverse Effects of Peripheral Alpha-1 Antagonists in Hypertension Therapy

  • Beneficial effect of enalapril in SHR cardiac remodeling with nitric oxide synthesis blockade

  • Calcium Antagonist Treatment by Lercanidipine Prevents Hyperpolarization in Essential Hypertension

  • Caspase-Dependent Cell Death Mediates the Early Phase of Aortic Hypertrophy in SHR

  • Differential Expression of AT1 Receptors in the Pituitary and Adrenal Gland of SHR and WKY

  • Exercising Restraint in Measuring Blood Pressure in Conscious Mice

  • Genetic disruption of-melanocyte–stimulating hormone signaling leads to salt-sensitive hypertension

  • History of Hypertension and Enhanced Thrombogenic Activity in Postinfarction Patients

  • Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life

  • Increased Superoxide Generation Is Associated With Pulmonary Hypertension in Fetal

  • Left Atrial Ejection Force (LAEF) in Patients With Hypertension

  • Maternal-Fetal Flow, Negative Events, and Preeclampsia-Role of ACE I-D Polymorphism

  • NADPH Oxidase Activity in Preeclampsia With Immortalized Lymphoblasts Used as Models

  • Negative regulators of sodium transport in the kidney-Key factors in understanding salt-sensitive hypertension

  • Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

  • Parallel Renal and Extremity Blood Supply Abnormalities in Nonmodulation-Responses to ACE Inhibition

  • PI3-Kinase-Induced Hyperreactivity in DOCA-Salt Hypertension Is Independent of GSK-3 Activity

  • Plasma Brain Natriuretic Peptide Levels and Blood Pressure Tracking in the Framingham Heart Study

  • Pressure-Induced Activation of Extracellular Signal-Regulated Kinase 1-2 in Small Arteries

  • regulators of sodium transport in the kidney-Key factors in understanding salt-sensitive hypertension

  • review of the adverse effects of peripheral alpha-1 antagonists in hypertension therapy

  • Salt-sensitive hypertension

  • Should hypertension be treated with angiotensin-converting-enzyme inhibitors, calcium-channel blockers or diuretics

  • Treatment of pulmonary hypertension

  • 20-HETE and Furosemide-Induced Natriuresis in Salt-Sensitive Essential Hypertension

  • Abolition of End-Organ Damage by Antiandrogen Treatment in Female Hypertensive Transgenic Rats

  • Activation of RhoA and Inhibition of Myosin Phosphatase as Important Components in Hypertension in VSMC

  • Administration Time-Dependent Influence of Aspirin on Blood Pressure in Pregnant Women

  • Adult Rabbit Offspring of Mothers With Secondary Hypertension Have Increased Blood Pressure

  • Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertension

  • Anandamide-Induced Depressor Effect in Spontaneously Hypertensive Rats-Role of the Vanilloid Receptor

  • Association Between Periodontal Disease and Left Ventricle Mass in Essential Hypertension

  • Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks

  • Body mass index is the main risk factor for arterial hypertension

  • Cardiac Transcriptome Analysis in Obesity-Related Hypertension

  • Characterization of an Animal Model of Postmenopausal Hypertension in Spontaneously Hypertensive Rats

  • Contrasting Regression of Blood Pressure and Cardiovascular Structure in Renovascular Hypertensive

  • Contributions of 20-HETE to the Antihypertensive Effects of Tempol in Dahl Salt-Sensitive Rats

  • Cytochrome P450 Enzymes and Impaired Vasodilation With Angiotensin Salt-Sensitive Hypertension

  • DASH Diet Lowers Blood Pressure and Lipid-Induced Oxidative Stress in Obesity

  • Downregulation of Basal iNOS at the Rostral Ventrolateral Medulla Is Innate in SHR

  • Doxycycline induced intracranial hypertension

  • Effects of Different Dihydropyridines on Sympathetic and Baroreflex in Hypertension

  • Enhancement of Intrarenal Angiotensinogen in Dahl Salt-Sensitive Rats on High Salt Diet

  • Evaluation of tissue kallikrein activity on survival time after acute coronary artery ligation in hypertensive rats

  • Family History of Hypertension and Type 2 Diabetes in Relation to Preeclampsia Risk

  • Glomerular autacoids stimulated by bradykinin regulate efferent arteriole tone

  • GTP Cyclohydrolase 1 Downregulation Contributes to Glucocorticoid Hypertension

  • Human Chromosome 17 in Essential Hypertension

  • Kinin B2 receptor localization and expression in the hypothalamo–pituitary–adrenal axis of spontaneously hypertensive rats

  • Left Ventricular Concentric Geometry as a Risk Factor in Gestational Hypertension

  • Low-Density Lipoprotein Subfractions and Cardiovascular Risk in Hypertension

  • Myocardial PKC [beta]2 and Na-K-ATPase to Marinobufagenin Are Reduced by Cicletanine in Hypertension

  • Myocardial Uptake and Biochemical and Hemodynamic Effects of ACE Inhibitors in Humans

  • Na-H Exchange Isoform 1 Is Involved in Mineralocorticoid-Salt-Induced Cardiac Injury

  • Outcomes With Nifedipine GITS or Co-Amilozide in Hypertensive Diabetics

  • Placental Insufficiency Leads to Development of Hypertension in Growth-Restricted Offspring

  • Rapid Child Growth Raises Blood Pressure in Adolescent Boys Who Were Thin at Birth

  • Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance

  • Role of Na+-H+ exchanger in acetylcholine-mediated pulmonary artery contraction of Spontaneously hypertensive

  • Role of the Subfornical Organ in the Chronic Hypotensive Response to Losartan in Normal Rats

  • Roles of Oxidative Stress and AT1 Receptors in Renal Hemodynamics and Oxygenation in 2K,1C Kidney

  • Self-Perpetuating Effects of Birth Size on Blood Pressure Levels in Elderly People

  • ST Segment Depression Criteria and the Prevalence of Silent Cardiac Ischemia in Hypertensives

  • Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy

  • The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats

  • A review of the adverse effects of peripheral alpha-1 antagonists in hypertension therapy

  • Activation of the Fas-Fas ligand pathway in hypertensive renal disease in Dahl-Rapp rats

  • Altered Tropomyosin Expression in Essential Hypertension

  • An Analysis of Antihypertensive Drug Prescribing in the Aftermath of the Calcium Channel Blocker Scare

  • Angiotensin-converting enzyme inhibition in adult hypertensive rats

  • Antihypertensive Treatments Obscure Familial Contributions to Blood Pressure Variation

  • Antioxidant-Rich Diet Relieves Hypertension and Reduces Renal Immune Infiltration in SHR

  • Atrial Fibrillation in Hypertension

  • Blood Pressure Response to Hyperventilation Test Reflects Daytime Pressor Profile

  • Coronary Vasodilator Capacity and Hypertension-Induced Increase in Left Ventricular Mass

  • Differential alterations in sympathetic neurotransmission in mesenteric arteries and veins in DOCA-salt hypertensive rats

  • Differential expression of vasopressin V1a and V1b receptors mRNA in the brain of renin transgenic TGR

  • Differential regulation of nitric oxide synthases and their allosteric regulators in heart and vessels of hypertensive rats

  • Effect of hypertension and candesartan on the blood flow velocity of the extraocular vessels in hypertensive patients

  • Effect of Sodium Intake on Sympathetic and Hemodynamic Response to Thermal Receptor Stimulation

  • Effects of Isosorbide Mononitrate and AII Inhibition on Pulse Wave Reflection in Hypertension

  • Effects of Severe Hypertension on Endothelial and Platelet Microparticles

  • False Claims of Blood Pressure-Independent Protection by Blockade of the Renin Angiotensin Aldosterone

  • Haplotype Analysis of the Human Renin Gene and Essential Hypertension

  • Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

  • Hypertension, Platelets, and the Endothelium

  • Hypertensive Emergencies- Etiology and Management

  • Hypertensive risk factors in kidney disease

  • Important New Advances in Modeling Antihypertensive Treatment Effects in Genetic Studies of Hypertension

  • Increased Systolic Performance With Diastolic Dysfunction in Adult Spontaneously Hypertensive Rats

  • Initial Treatment of Hypertension

  • Lipid Peroxidation Is Not Increased in Patients With Untreated Mild-to-Moderate Hypertension

  • Mice Lacking Endothelial ACE

  • Morning Blood Pressure Peak, QT Intervals, and Sympathetic Activity in Hypertensive Patients

  • Myocardial Ultrasonic Backscatter in Hypertension

  • Nephron Number, Renal Function, and Arterial Pressure in Aged GDNF Heterozygous Mice

  • Nitric Oxide Opposes Glucose-Induced Hypertension by Suppressing Sympathetic Activity

  • NOS3 Genotype-Dependent Correlation Between Blood Pressure and Physical Activity

  • Overexpression of eNOS in RVLM Improves Impaired Baroreflex Control of Heart Rate in SHRSP

  • Peroxisome Proliferator-Activated Receptor-[gamma] Coactivator-1 Gene Locus

  • Prenatal Dexamethasone Programs Hypertension and Renal Injury in the Rat

  • Radical-Trapping Activity, Blood Pressure, and Carotid Enlargement

  • Regression of Hypertensive Myocardial Fibrosis by Na+-H+ Exchange Inhibition

  • Renal Sympathetic Nerve Responses to Tempol in Spontaneously Hypertensive Rats

  • Renoprotection by ACE Inhibition or Aldosterone Blockade Is Blood Pressure-Dependent

  • Restoration of arterial baroreflex function contributes to organ protection in SHR

  • RGS2- a turn-off in hypertension

  • Treating Hypertension — What Are We to Believe

  • Wall Stiffness Suppresses Akt-eNOS and Cytoprotection in Pulse-Perfused Endothelium

  • Ablation of NK1 Receptors in Rat Nucleus Tractus Solitarii Blocks Baroreflexes

  • Angiotensin II and Oxidative Stress in Dahl Salt-Sensitive Rat With Heart Failure

  • Ascorbic Acid Reduces Blood Pressure and Arterial Stiffness in Type 2 Diabetes

  • Augmented Diurnal Variations of the Cardiac Renin-Angiotensin System in Hypertensive Rats

  • Blunted Tubuloglomerular Feedback by Absence of Angiotensin Type 1A Receptor Involves Neuronal NOS

  • Calcium Channel Antagonists in the Treatment of Hypertension

  • Classification of Blood Pressure Levels by Ambulatory Blood Pressure in Hypertension

  • Diagnosis of Pheochromocytoma

  • Effects of Doxazosin and Propranolol on A2A Adenosine Receptors in Essential Hypertension

  • Endocrine Tumors Causing Hypertension

  • Health-Related Quality-of-Life Assessments and Patient-Physician Communication

  • Hypertension and Hypokalemia with cushing syndrome

  • Insulin Resistance But Not Inflammation Is Associated With Gestational Hypertension

  • Lack of Long-Term Effect of Vitamin C Supplementation on Blood Pressure

  • Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor

  • Pheochromocytoma

  • Prevalence, Awareness, Treatment, and Control of Hypertension in China

  • Primary Aldosteronism

  • Reactivity as a Predictor of Subsequent Blood Pressure

  • Serum Antioxidant Vitamins and Blood Pressure in the United States Population

  • The Verdict From ALLHAT-Thiazide Diuretics Are the Preferred Initial Therapy for Hypertension

  • cv-hypertrophy-Midwall myocardial shortening in athletic left ventricular hypertrophy

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  • 更新于2003-05-20