Molecular Imaging



Molecular Imaging
当今生命科学遇到的挑战表现在对生命现象的定量和精确描述上。所谓定量主要表现在从分子水平上把物质的运动规律定量的描述出来, 同时在时空上是足够精确的。体内分子成像可在机体完整的微环境状态下观察生物系统的病理过程。此外，与现今仍然以人体解剖学和病理学为基础的核医学成像技术、磁共振成像技术（MR）和光学成像技术相比，分子成像已深入到在纳米尺寸的单个生物分子水平上进行研究，使疾病在基因水平上的早期诊断和监测以及更进一步地微观评价疗效成为可能。美国NIH于2002年度投资510万美元资助医学分子成像系统和方法的研究，此类研究成果与技术可望被广泛用于生物学和疾病的研究。为了方便广大师生和研究人员进一步了解分子成像的信息，现将近两年的综述和报道列举如下供大家参考，更多的文献请查阅CMBI的综述查询和相关栏目。
Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools Can small animal imaging accelerate drug development Chemical microarrays, fragment diversity, label-free imaging by plasmon resonance-a chemical genomics approach Combined vascular targeted imaging and therapy Evolution of radiopharmaceuticals for diagnosis and therapy Fluorescence emission-based detection and diagnosis of malignancy Functional and molecular MR imaging of angiogenesis Grappling with metastatic risk-Bringing molecular imaging of Met expression toward clinical use In vivo molecular imaging In vivo molecular-genetic imaging Introduction to the physics of molecular imaging with radioactive tracers in small animals Magnetic resonance microscopy approaches to molecular imaging Model-based biological Raman spectral imaging Molecular imaging in small animals-roles for micro-CT Molecular imaging of regional brain tumor biology Molecular imaging of tumor angiogenesis Molecular imaging-An old and new field connecting basic science and clinical medicine Molecular imaging-New applications for biochemistry Molecular imaging-The application of small animal positron emission tomography Nanobiosensors-Probing the sanctuary of individual living cells Non-invasive imaging of reporter genes Non-invasive imaging of vulnerable plaques by molecular targeting of oxidized LDL with tagged oxidation-specific antibodies Observations on the role of nuclear medicine in molecular imaging Prospects of molecular imaging in neurology Quantitative assessment of tumor oxygen dynamics-Molecular imaging for prognostic radiology Radionuclide imaging in the post-genomic era Understanding immune cell trafficking patterns via in vivo bioluminescence imaging drug discovery-MOLECULAR IMAGING IN DRUG DISCOVERY AND DEVELOPMENT A Molecular Map for Neurodegeneration Advances in Biomedical Imaging Molecular imaging of cancer with positron emission tomography A clearer vision for in vivo imaging A Noninvasive Molecular Imaging Model of Prostate Cancer Suicide Gene Therapy ADVANCES IN IN VIVO BIOLUMINESCENCE IMAGING OF GENE EXPRESSION Direct Imaging of Transient Molecular Structures with Ultrafast Diffraction In Vivo Imaging of Proteolytic Activity in In Vivo Molecular Imaging of Met Tyrosine Kinase Growth Factor Receptor Activity in Normal Organs and Breast Tumors Kinetic modelling approaches to in vivo imaging Magnetic relaxation switches capable of sensing molecular interactions Microscope-based techniques to study cell adhesion and migration Molecular Imaging and Gene Therapy MOLECULAR IMAGING WITH POSITRON EMISSION TOMOGRAPHY Molecular topography imaging by intermembrane fluorescence resonance energy transfer MRI and Characterization of Atherosclerotic Plaque-Emerging Applications and Molecular Imaging MRI Contrast Agent for Molecular Imaging of Fibrin Optical biosensors in drug discovery Picture perfect Positron emission tomography provides molecular imaging of biological processes Pushing, pulling, dragging, and vibrating renal epithelia by using atomic force microscopy Shedding light onto live molecular targets Turning the spotlight on cellular imaging Two-photon tissue imaging cv-ultrasonic-Targeted ultrasonic contrast agents for molecular imaging and Therapy biotech-Developments in whole-body molecular imaging of live subjects Novel MRI Contrast Agent for Molecular Imaging of Fibrin

Last Modified: 2003-03-09