obesity



Obesity
肥胖对人类健康的危害早已被广大医学专家和社会所公认，并已被WHO列为危害人类的全球10大健康问题之一。众所周知，肥胖的流行可以导致心血管疾病、糖尿病和肿瘤等多种疾病的发病率增高，但由于肥胖的病因和机制及其复杂，所以临床上还没有研究出一个很好的方法和药物来针对肥胖及其肥胖带来的负面影响。最近Science上报道了多篇有关肥胖的新闻，涉及到分子遗传学、肥胖病因的研究、如何预防以及药物的靶向治疗等领域，希望能给人们带来新的希望。下面我们收集了有关肥胖的最新报道和综述250多篇，并作了较系统的分类，供大家参考，更多的文章请使用cmbi文献查询：
以下是Science上发表的几篇文章： A Clinical View of the Obesity Problem A War on Obesity, Not the Obese Obesity and the Environment- Where Do We Go from Here Obesity Drug Pipeline Not So Fat The Ironic Politics of Obesity Cellular Warriors at the Battle of the Bulge
流行病发病机理 Leptin与脂代谢肥胖与心血管疾病肥胖与糖尿病肥胖与肿瘤肥胖的预防与治疗其他	流行病 Epidemiological study on obesity and its comorbidities in urban Chinese older than 20 years of age Twenty-year changes in the prevalence of overweight in Japanese adults Asians are different from Caucasians and from each other in their body mass index-body fat Obesity in Malaysia The relationship between body mass index and the prevalence of related diseases based in Korea Weight loss causes increased mortality Weight loss causes increased mortality-2 A War on Obesity, Not the Obese What Is To Be Done obesity epidemic in young children Obesity Hypertension in Children-A Problem of Epidemic Proportions Epidemiological study on obesity and its comorbidities in urban Chinese Public Health-The Public Health Problem of Increasing Prevalence Rates of Obesity and What Should Be Done About It THE PUBLIC HEALTH IMPACT OF OBESITY public health-MINISYMPOSIUM ON OBESITY Public Health-MINISYMPOSIUM ON Overview and Some Strategic Considerations Asians are different from Caucasians and from each other in body mass index-body fat per cent relationship The biology of white adipocyte proliferation Is obesity an inflammatory condition The investigation and management of obesity Appropriate Asian body mass indices back 发病机理 The biomechanics of adiposity - structural and functional limitations of obesity Energy balance and pollution by organochlorines and polychlorinated biphenyls Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity GENETICS AND PATHOPHYSIOLOGY OF HUMAN OBESITY Dietary fat is a major player in obesity - but not the only one Dietary fat plays a major role in no Obesity and the Environment- Where Do We Go from Here Obesity and the Environment Hypothalamic obesity in humans Adiponectin and resistin-Resistin-Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator-Activated Receptor-[gamma] Action in Humans Adiponectin and resistin-Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-Action Contemporary Challenges in Obesity and Eating Disorders What Mental Health Professionals Need to Know PREVENTING OBESITY IN CHILDREN AND ADOLESCENTS Accumulation of Triglyceride-Rich Lipoprotein in Subjects With Abdominal Obesity Association Between SAH- an Acyl-CoA Synthetase Gene- and Hypertriglyceridemia, Obesity, and Hypertension The mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men DGAT and Triglyceride Synthesis; A New Target for Obesity Treatment Resistin and associated insulin resistance Connections between obesity and dyslipidaemia related phenotypes interaction with a common lipoprotein lipase gene variation Skeletal Muscle Lipoprotein Lipase-Mediated Resistance to Obesity and Insulin Action Results in Increased Expression of Munc18c Adipogenesis and fat-cell function in obesity and diabetes A ‘thrifty’ gene linked to obesity Diseases of liporegulation- new perspective on obesity and related disorders Effects of the Magenstrasse and Mill operation for obesity on plasma leptin and insulin resistance The biomechanics of adiposity-structural and functional limitations of obesity and implications for movement Pathogenesis of obesity and diabetes mellitus Pathogenesis of obesity and diabetes mellitus - insights provided by indirect calorimetry in humans Pathogenesis of obesity and diabetes mellitus- insights provided by indirect calorimetry in humans EFFECTS OF NEUROPEPTIDES AND LEPTIN ON NUTRIENT PARTITIONING- Dysregulations in Obesity The sympathetic neurobiology of essential hypertension: disparate influences of obesity, stress, and noradrenaline transporter dysfunction? rp-Neuropeptides and obesity physiol-Body Weight-Adiposity Regulation-Genetics of Pathways Regulating Body Weight in the Development of Obesity in Humans peptide-orexin-Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist Protection From Obesity in Mice Lacking the VLDL Receptor Participation of the Hypothalamus-Hypophysis Axis in the Sympathetic Activation of Human Obesity The peripheral sympathetic nervous system in human obesity Metabolic precursors and effects of obesity in children Expression of 11[beta]-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue Cortisol, 11\|?-hydroxysteroid dehydrogenase type 1 and central obesity Adipocyte apoptosis in the regulation of body fat mass by leptin POMC processing in the hypothalamus-impact on melanocortin signalling and obesity The Human Obesity Gene Map-The 2000 Update The Human Obesity Gene Map-The 2001 Update Metabolically active components of fat-free mass and resting energy expenditure in humans Dietary fat plays a major role in obesity A role for olestra in body weight management Elevated C-Reactive Protein : Another Component of the Atherothrombotic Profile of Abdominal Obesity back Leptin与脂代谢 endocrin-obesity-The Human Obesity Gene Map-The 2000 Update endocrin-obesity-The Human Obesity Gene Map-The 2001 Update cv-hypertension-Obesity-related Hypertension-Role of the Sympathetic Nervous System, Insulin, and Leptin obesity-Adipocyte apoptosis in the regulation of body fat mass by leptin Obesity hypertension: role of leptin and sympathetic nervous system Effects of the Magenstrasse and Mill operation for obesity on plasma leptin and insulin resistance Obesity -EFFECTS OF NEUROPEPTIDES AND LEPTIN ON NUTRIENT PARTITIONING- Dysregulations in Obesity Obesity, leptin and blood pressure among children in Taiwan: the Taipei children's heart study cv-risk-Influence of Leptin on Arterial Distensibility-A Novel Link Between Obesity and Cardiovascular Disease cv-hp-Adenoviral leptin as gene therapy for obesity related hypertension, respir-TLeptin and the obesity hypoventilation syndrome cv-diabetes-LIPIDS AND INSULIN RESISTANCE-Uncoupling Proteins, Leptin, and Obesity cv-Inflammation, Thrombosis, and Atherosclerosis-Prothrombotic Effects of Leptin-Possible Implications for the Risk of Cardiovascular Disease in Obesity back 肥胖与心血管疾病 Obesity, coronary heart disease risk factors and diabetes in Chinese body fat percentage and cardiovascular risks at low body mass index among Chinese, Malays and Indians The lifecycle effects of nutrition and body size on adult adiposity, diabetes and cardiovascular disease Overweight is an independent risk factor for cardiovascular disease in Chinese populations and cardiovascular risk factors in Hong Kong Chinese Obesity, low for gestational age birth weight, and subsequent cardiovascular risk adrenoceptor-Alpha2-adrenoceptor function in arterial hypertension associated with obesity childhood hypertension-Obesity hypertension Current Reports-Hypertension-Pathophysiology of Obesity Hypertension epidemol-Longitudinal Analysis of Changes in Indices of Obesity from Age 8 Years to Age 18 Years GENETICS AND PATHOPHYSIOLOGY OF HUMAN OBESITY Ghrelin, growth and obesity childhood hypertension-Obesity hypertension Gender difference in diet-induced obesity hypertension-implication of renal 2-adrenergic receptors Obesity hypertension Obesity, hypertension and the sympathetic nervous system hyperten-Obesity and hypertension Inflammation, Thrombosis, and Atherosclerosis-Prothrombotic Effects of Leptin-Possible Implications for the Risk of Cardiovascular Disease in Obesity Obesity and the Regulation of Energy Balance-cell Adiponectin and resistin-5' Flanking Variants of Resistin Are Associated With Obesity Adiponectin and resistin-Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by PPAR Adiponectin and resistin-missing link with obesity Adiponectin and resistin-Resistin and Resistin-Like Molecules Also Link Obesity to Inflammatory Diseases Adiponectin and resistin-Variants of Resistin Are Associated With Obesity Ghrelin, growth and obesity ghrelin-Circulating Ghrelin Levels Are Decreased in Human Obesity Hemodynamic consequences of neuropeptide Y-induced obesity Sympathetic Neural Activation in Visceral Obesity remodeling-Association between obesity and coronary atherosclerosis and vascular remodeling Influence of Leptin on Arterial Distensibility-A Novel Link Between Obesity and Cardiovascular Disease Nutritionally Induced Obesity Is Attenuated in Transgenic Plasminogen Activator Inhibitor-1 Obesity Accelerates the Progression of Coronary Atherosclerosis in Young Men Obesity and the Risk of Heart Failure Obesity as a disease entity Obesity as a risk factor in coronary artery disease Obesity assessment Obesity, Metabolic Syndrome, and Coronary Atherosclerosis Obesity, the metabolic syndrome, and cardiovascular disease Cardiologists should target obesity Pathophysiology of Associated Cardiovascular Disease Urocortin-Mutation Screening of the Urocortin Gene-Identification of New Single Nucleotide Polymorphisms and Association Studies with Obesity Obesity hypertension: role of leptin and sympathetic nervous system Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites Obesity May Not Be Bad for Heart Failure Patients Obesity and cardiovascular risk factors in Hong Kong Chinese Oxidative Stress in a Rat Model of Induced Hypertension Associated Cardiovascular Disease Obesity, leptin and blood pressure among children in Taiwan: the Taipei children's heart study Obesity in the pediatric patient: cardiovascular complications treatment of related hypertension. therapy-Pharmacotherapy of Obesity Current Reports-Diet and Pharmacologic Therapy of Obesity to Modify Atherosclerosis Adenoviral leptin as gene therapy for obesity related hypertension, The renin-angiotensin system and natriuretic peptides in associated hypertension the effects on cardiovascular and renal systems, Heritability Estimates of Obesity Measures in Siblings With and Without Hypertension Overweight is an independent risk factor for cardiovascular disease in Chinese populations back 肥胖与糖尿病 obosity-of free fatty acids on insulin secretion in obesity Current Reports-harmacologic Treatment of Type 2 Diabetes Mellitus and Obesity Current Reports-Nutritional Treatment of Type 2 Diabetes Mellitus and Obesity Current Reports-Obesity and Sedentary Lifestyle-Modifiable Risk Factors for Prevention of Type 2 Diabetes Genetics of human obesity therapy-Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity Obesity, coronary heart disease risk factors and diabetes in Chinese LIPIDS AND INSULIN RESISTANCE-Neuroimaging and Obesity LIPIDS AND INSULIN RESISTANCE-New Approaches to Gene Discovery with Animal Models of Obesity and Diabetes LIPIDS AND INSULIN RESISTANCE-Positional Cloning of an Obesity-Diabetes Susceptibility Gene(s) on Chromosome 11 LIPIDS AND INSULIN RESISTANCE-Uncoupling Proteins, Leptin, and Obesity LIPIDS AND INSULIN RESISTANCE-Is a Pro12Ala Polymorphism of the PPAR2 Gene Related to Obesity and Type 2 Diabetes Mellitus Regulation of Insulin Production-Genetics of Obesity and Type 2 Diabetes Adiponectin and resistin-a new link between obesity and insulin resistance Adiponectin and resistin-adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Adiponectin and resistin-Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity Adiponectin and resistin-Resistin and obesity-associated insulin resistance Adiponectin and resistin-Resistin, Obesity, and Insulin Resistance Current Reports-Hypertension-Hypertension and Metabolic Disarray-Diabetes Mellitus, Insulin Resistance and Obesity hypertension-Insulin-mediated sympathetic stimulation-role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why) hypertension-Obesity-related Hypertension-Role of the Sympathetic Nervous System, Insulin, and Leptin hyprtension-Insulin-mediated sympathetic stimulation-role in the pathogenesis of obesity-related hypertension Adiponectin and resistin-The hormone resistin links obesity to diabetes risk-Cardiovascular risk factors in children with obesity, hypertension and diabetes The Glycemic Index-Physiological Mechanisms Relating to Obesity, Diabetes, and Cardiovascular Disease Adiponectin and resistin-Human Resistin Gene, Obesity, and Type 2 Diabetes Adiponectin and resistin-Hypoadiponectinemia in Obesity and Type 2 Diabetes Adiponectin and resistin-Resistin, central obesity, and type 2 diabetes Adiponectin and resistin-Resistin-a new hormone that links obesity with type 2 diabetes The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity bi-The mouse SWISS-2D PAGE database- a tool for proteomics study of diabetes and obesity Circulating lipoproteins and hepatic sterol metabolism in Psammomys obesus prone to obesity, hyperglycemia and hyperinsulinemia Endocrine-The crucial role of a phosphatase in insulin resistance and obesity New Approaches to Gene Discovery with Animal Models of Obesity and Diabetes obesity-A central role for JNK in obesity and insulin resistance pediatric-Obesity and insulin resistance in young people MP-UCP- Major Link between Obesity, Cell Dysfunction, and Type 2 Diabetes molecular medicine-Obesity and an avalanche of new information Inhibition of Platelet-Collagen Interaction -An In Vivo Action of Insulin Abolished by Insulin Resistance in Obesity Impaired glucose metabolism and obesity in Swedish patients with borderline isolated systolic hypertension: Skaraborg Hypertension and Diabetes Project Factor VII, Tissue Factor Pathway Inhibitor, and Monocyte Tissue Factor in Diabetes Mellitus: Influence of Type of Diabetes, Obesity Index, and Age Pancreatic-cell growth and survival –a role in obesity-linked type 2 diabetes obesity-Effects of free fatty acids on insulin secretion in obesity back 肥胖与肿瘤 Weight control and physical activity in cancer prevention Weight control, physical activity and cancer prostate cancer-Is obesity a risk factor for prostate cancer 肥胖的预防与治疗 Preventive strategies against weight gain and obesity From instinct to intellect- the challenge of maintaining healthy weight in the modern world An updated systematic review of interventions to improve health professionals' management of obesity A role for olestra in body weight management Obesity Drug Pipeline Not So Fat Treatment of obesity A Clinical View of the Obesity Problem Anti-obesity drugs-a critical review of current therapies and future opportunities discovery-OBESITY THERAPY-ALTERING THE ENERGY INTAKE-AND-EXPENDITURE BALANCE SHEET Sibutramine_A SEROTONIN¨CNOREPINEPHRINE REUPTAKE-INHIBITOR FOR THE TREATMENT OF OBESITY Drug Therapy-Obesity Anti-obesity drugs-drug drug sibutramine (Meridia)-hypertension and cardiac arrhythmias Mitochondrial uncoupling as a target for drug development for the treatment of obesity Protein tyrosine phosphatase 1B-a new target for the treatment of obesity and associated co-morbidities Combining Behavioral and Pharmacological Treatments for Obesity mp-Treatment of obesity obesity -The health at any size paradigm for obesity treatment- the scientific evidence diagnosis, prevention, and treatment Recent developments in the treatment of related hypertension treatment of related hypertension. hyprtension-Choice of drug treatment for related hypertension-where is the evidence endocrine-Obesity therapy internal medicine-Long-term Pharmacotherapy of Obesity 2000 Antiobesity pharmacotherapy in the management of Type 2 diabetes Obesity and its surgical management Abdominal adiposity predicts endothelial dysfunction in uncomplicated obesity: an analysis of traditional and novel risk factors Clinical aspects of obesity in childhood and adolescence Preventive strategies against weight gain and obesity medicine-Inhibition of gastric inhibitory polypeptide signaling prevents obesityi The Prevention of Obesity PREVENTING OBESITY IN CHILDREN AND ADOLESCENTS Interventions for preventing obesity in childhood Prevention of obesity - is it possible PUBLIC HEALTH-PREVENTING OBESITY IN CHILDREN AND ADOLESCENTS pediatric-The management of obesity Taste, food intake and obesity ENVIRONMENTAL INFLUENCES ON EATING AND PHYSICAL ACTIVITY Adipocyte apoptosis in the regulation of body fat mass by leptin THE PUBLIC HEALTH IMPACT OF OBESITY n updated systematic review of interventions to improve health professionals management of obesity From instinct to intellect-the challenge of maintaining healthy weight in the modern world back 其他 The Ironic Politics of Obesity Approaching healthy body mass index norms for children and adolescents Childhood obesity Metabolically active components of fat-free mass and resting energy expenditure in humans Obesity, haemostasis and the fibrinolytic system Assessment of Free-Living Physical Activity in Humans Gastro-oesophageal reflux disease in obesity New Insights in Obesity Obesity, haemostasis and the fibrinolytic system Resting Energy Expenditure the science behind the management gall-bladder motor function in obesity Obesity Obesity Obesity and health-related quality of life ENVIRONMENTAL INFLUENCES ON EATING AND PHYSICAL ACTIVITY Bias, Discrimination, and Obesity Childhood overweight MINISYMPOSIUM ON OBESITY Quality of life and obesity the role of thermogenesis in human obesity PUBLIC HEALTH IMPACT OF OBESITY public healthTHE PUBLIC HEALTH IMPACT OF OBESITY Self-reported weight and height Implications for obesity research 　 back

更新于2003-02-20