Protein Folding

        蛋白质的生物活性不仅决定于蛋白质分子的一级结构，而且与其特定的空间结构密切相关。异常的蛋白质空间结构很可能导致其生物活性的降低、丧失，甚至会导致疾病，疯牛病，Alzheimer's 症等都是由于蛋白质折叠异常引起的疾病。蛋白质如何在细胞内正确地折叠？为什么这个过程有时会失败？过去四十年间关于蛋白质折叠过程的研究集中在当变性剂被缓冲液稀释后变性的蛋白质如何再重新折叠这一问题上。但是这样的体外研究与真正的细胞内情况相去甚远。强调活体细胞内的蛋白质正常折叠、异常折叠的研究，尤其是折叠催化剂、分子伴侣和大分子的参与是这一领域目前的研究热点。在功能和结构细节上阐明关于蛋白质折叠的过程将对相关疾病的预防和治疗有重要意义。为此CMBI特为大家准备了关于蛋白质折叠的特别报道，更多文献敬请查阅CMBI的文献查询。

• biophys-protein folding-A Cardiologist's Introduction to Protein Folding and Degradation
  
• biophys-protein folding-A fully automatic evolutionary classification of protein folds
  
• biophys-protein folding-A global representation of the protein fold space
  
• biophys-protein folding-A Pharmacological Strategy for Disorders of Protein Folding and Trafficking
  
• biophys-protein folding-A Subset of Chaperones and Folding Enzymes Form Multiprotein Complexes in Endoplasmic Reticulum to Bind Nascent Proteins
  
• biophys-protein folding-Alleviation of a Defect in Protein Folding by Increasing the Rate of Subunit Assembly
  
• biophys-protein folding-An affibody in complex with a target protein- Structure and coupled folding
  
• biophys-protein folding-An atomically detailed study of the folding pathways of protein A with the stochastic difference equation
  
• biophys-protein folding-Analysing Six Types of Protein–Protein Interfaces
  
• biophys-protein folding-Attraction within the membrane- Forces behind transmembrane protein folding and supramolecular complex assembly
  
• biophys-protein folding-Automatic classification of protein structure by using Gauss integrals
  
• biophys-protein folding-Biochemical basis of oxidative protein folding in the endoplasmic reticulum
  
• biophys-protein folding-biophys-protein folding-NMR spin relaxation methods for characterization of disorder and folding in proteins
  
• biophys-protein folding-Chaperonin-mediated protein folding
  
• biophys-protein folding-Chaperonins in disease- mechanisms, models, and treatments
  
• biophys-protein folding-Chaperonins in disease
  
• biophys-protein folding-Competition of Spontaneous Protein Folding and Mitochondrial Import Causes Dual Subcellular Location of Major Adenylate Kinase
  
• biophys-protein folding-Constructing smooth potential functions for protein folding
  
• biophys-protein folding-Coupling of folding and binding for unstructured proteins
  
• biophys-protein folding-Defective protein folding as a basis of human disease
  
• biophys-protein folding-Desolvation shell of hydrogen bonds in folded proteins, protein complexes and folding pathways
  
• biophys-protein folding-Diffusion-collision model study of misfolding in a four-helix bundle protein
  
• biophys-protein folding-Direct molecular dynamics observation of protein folding transition state ensemble.
  
• biophys-protein folding-Dissection of receptor folding and ligand-binding property with functional minireceptors of LDL receptor-related protein
  
• biophys-protein folding-Dynamics of Hydrogen Bond Desolvation in Protein Folding
  
• biophys-protein folding-Evolutionary aspects of protein structure and folding
  
• biophys-protein folding-Experimental evaluation of topological parameters determining protein-folding rates
  
• biophys-protein folding-Experimental Identification of Downhill Protein Folding
  
• biophys-protein folding-Extent of hydrogen-bond protection in folded proteins- A constraint on packing architectures
  
• biophys-protein folding-Folding and binding Emerging themes in protein folding and assembly
  
• biophys-protein folding-Folding and binding- Problems with proteins
  
• biophys-protein folding-Folding Intermediates of a Model Three-helix Bundle Protein
  
• biophys-protein folding-folding Nuclei in proteins
  
• biophys-protein folding-Folding of newly translated proteins in vivo- the role of molecular chaperones.;
  
• biophys-protein folding-Heat capacity of folding of proteins corrected for disulfide cross-links
  
• biophys-protein folding-Heat capacity of protein folding
  
• biophys-protein folding-Helical membrane protein folding, stability, and evolution
  
• biophys-protein folding-Hsp90- a specialized but essential protein-folding tool
  
• biophys-protein folding-in vitro folding of alpha-helical membrane proteins
  
• biophys-protein folding-Inaugural Article- An amino acid code for protein folding
  
• biophys-protein folding-Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
  
• biophys-protein folding-Intramolecular chaperones
  
• biophys-protein folding-Intramolecular modulation of electric fields in folding proteins
  
• biophys-protein folding-Is there a unifying mechanism for protein folding
  
• biophys-protein folding-Keeping it in the family- folding studies of related proteins
  
• biophys-protein folding-Keeping it in the family-folding studies of related proteins
  
• biophys-protein folding-Kinetic Intermediate in the Folding of Human Prion Protein
  
• biophys-protein folding-Lectin control of protein folding and sorting in the secretory pathway
  
• biophys-protein folding-Making a Network of Hydrophobic Clusters
  
• biophys-protein folding-Manipulation of oxidative protein folding and PDI redox state in mammalian cells
  
• biophys-protein folding-Mechanisms of protein folding
  
• biophys-protein folding-Membrane protein folding
  
• biophys-protein folding-Mitochondrial Hsp70 Ssc1- Role in Protein Folding
  
• biophys-protein folding-Molecular chaperones- containers and surfaces for folding, stabilising or unfolding proteins
  
• biophys-protein folding-Molecular Chaperones in the Cytosol- from Nascent Chain to Folded Protein
  
• biophys-protein folding-Molecular dynamics simulations of protein folding from the transition state
  
• biophys-protein folding-Multi-class protein fold recognition using support vector machines and neural networks
  
• biophys-protein folding-Native Topology or Specific Interactions- What is More Important for Protein Folding
  
• biophys-protein folding-Neurodegeneration in age of molecular biology-protein folding holds key to specific treatment
  
• biophys-protein folding-NOVEL FOLDING PATTERN FOR A SERINE PROTEIN KINASE
  
• biophys-protein folding-On the simulation of protein folding by short time scale molecular dynamics and distributed computing
  
• biophys-protein folding-Orchestrating the unfolded protein response in health and disease
  
• biophys-protein folding-Pathways in two-state protein folding
  
• biophys-protein folding-Pathways in two-state protein folding;
  
• biophys-protein folding-Peptide and protein folding
  
• biophys-protein folding-Prediction of Folding Mechanism for Circular-permuted Proteins
  
• biophys-protein folding-Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy
  
• biophys-protein folding-Protein aggregation in disease- a role for folding
  
• biophys-protein folding-Protein aggregation in disease-a role for folding intermediates forming specific multimeric interactions
  
• biophys-protein folding-Protein design based on folding models
  
• biophys-protein folding-Protein dynamics, folding and misfolding- from basic physical chemistry to human conformational diseases
  
• biophys-protein folding-Protein folding and function- The N-terminal fragment in adenylate kinase
  
• biophys-protein folding-Protein folding and three-dimensional domain swapping
  
• biophys-protein folding-Protein folding- bringing theory and experiment closer together
  
• biophys-protein folding-Protein folding cooperativity in the correlated lattice
  
• biophys-protein folding-Protein folding in vivo- the importance of molecular chaperones
  
• biophys-protein folding-Protein folding mechanisms- new methods and emerging ideas
  
• biophys-protein folding-Protein folding mediated by solvation
  
• biophys-protein folding-Protein folding pathways and kinetics- Molecular dynamics simulations of (beta)-strand motifs
  
• biophys-protein folding-Protein folding simulations and structure predictions
  
• biophys-protein folding-Protein folding taking shape- Workshop on molecular chaperones
  
• biophys-protein folding-Protein folding- the free energy surface
  
• biophys-protein folding-Protein folding theory- From lattice to all-atom models
  
• biophys-protein folding-Protein folding- Thickening the broth
  
• biophys-protein folding-Protein folding-could hydrophobic collapse be coupled with hydrogen-bond formation
  
• biophys-protein folding-Protein folding-progress made and promises ahead
  
• biophys-protein folding-Protein glucosylation and its role in protein folding
  
• biophys-protein folding-Protein model exhibiting three folding transitions
  
• biophys-protein folding-Protein structure prediction and structural genomics
  
• biophys-protein folding-Protein unfolding transitions in an intrinsically unstable annexin domain
  
• biophys-protein folding-Protein-misfolding diseases
  
• biophys-protein folding-Recent advances in the genetics and pathogenesis of Parkinson disease
  
• biophys-protein folding-Rescuing protein conformation- prospects for pharmacological therapy in cystic fibrosis
  
• biophys-protein folding-Roles of molecular chaperones in cytoplasmic protein folding
  
• biophys-protein folding-Self-consistent determination of the transition state for protein folding
  
• biophys-protein folding-Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein
  
• biophys-protein folding-Sequence evolution and the mechanism of protein folding
  
• biophys-protein folding-Simulated refolding of stretched titin immunoglobulin domains
  
• biophys-protein folding-Simulations of Protein Folding
  
• biophys-protein folding-Structural genomics- An approach to the protein folding problem
  
• biophys-protein folding-structure-based method for derivation of all-atom potentials for protein folding
  
• biophys-protein folding-Structures and Functions of Chaperones and Chaperonins
  
• biophys-protein folding-Sulfhydryl oxidases- emerging catalysts of protein disulfide bond formation in eukaryotes
  
• biophys-protein folding-Surfing on protein folding energy landscapes
  
• biophys-protein folding-The action of molecular chaperones in the early secretory pathway
  
• biophys-protein folding-The cellular response to aggregated proteins associated with human disease
  
• biophys-protein folding-The complete folding pathway of a protein from nanoseconds to microseconds
  
• biophys-protein folding-The protective shell of a hydrogen bond- a motif in protein folding pathways
  
• biophys-protein folding-The structure of the protein universe and genome evolution
  
• biophys-protein folding-Thermodynamics and Kinetics of Protein Folding
  
• biophys-protein folding-Topological determinants of protein folding
  
• biophys-protein folding-Trans-Suppression of Misfolding in an Amyloid Disease
  
• biophys-protein folding-Variable velocity liquid flow EPR applied to submillisecond protein folding
  
• biophys-protein folding-Viewing protein folding from many perspectives
  
• biophys-protein folding-Visualization of coupled protein folding and binding in bacteria and purification of the heterodimeric complex
  
• biophys-protein folding-What are the baselines for protein fold recognition
  
• biophys-protein folding-Zinc-dependent protein folding
  
• biochem-Is there a unifying mechanism for protein folding
  
• biochem-Lectin control of protein folding and sorting in the secretory pathway
  
• drug discovery-PROTEIN FOLDING AND DISEASE- A VIEW FROM THE FIRST HORIZON SYMPOSIUM
  
• protein-Is tensegrity a unifying concept of protein folds
  
• Structural Biology -Early events in protein folding
  
• Structural Biology -Folding and binding — new technologies and new perspectives
  
• Structural Biology -protein folding- bringing theory and experiment closer together
  
• Structural Biology -Protein unfolding — an important process in vivo
  
• Structural Biology -Single-molecule folding
  
• bi-Species-specific protein sequence and fold optimizations
  
• cell-Folding of the Voltage-gated K+ Channel T1 Recognition Domain
  
• medicine-Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics
  
• protein-The complete folding pathway of a protein from nanoseconds to microseconds
  
• Structural Biology -Evolutionary aspects of protein structure and folding