Vitamin D

        众所周知，维他命D是人体必需的营养素，可以说它既是一种维生素，也属激素范畴，是人体钙吸收最重要的调节因子，一般情况下人们可以从适量的阳光照射下获得。先前的研究已发现，维生素D是矿物质内稳定以及适当骨形成和维持的重要激素。但除了对矿物质平衡具有作用以外，维生素D对机体还有更广泛的作用，如最新的进展表明，VD可以预防骨质疏松症、治疗和预防冠心病、治疗慢性肾衰。在2002年4月召开的美国心脏学会亚太科学论坛会议上，来自美国圣佛朗西斯科加利福尼亚大学和VA医学中心的Varosy博士报告说，他们最近完成的一项研究结果显示，65岁以上的妇女服用维生素D，其冠心病死亡危险较未服用者降低近1/3。国际知名杂志science于2002年5月报道说：维生素Ｄ可以降低人们患结肠癌的风险，科研人员指出，维生素Ｄ能帮助解除消化过程中生成的石胆酸的毒性，从而预防结肠癌的发生。但在看到VD优点的同时也应该注意到VD也是最容易产生过量或安全顾虑的维他命，因为它负责从肠道吸收钙质，长期且大剂量的使用能导致软组织的钙化。所以应从多样化饮食中获取适量的VD以保证人们的健康。为此CMBI特为大家准备了关于维生素D的特别报道，更多文献敬请查阅CMBI的文献查询。

• Modulation of TNF- expression in bone marrow macrophages-Involvement of vitamin D response element
  
• New insights into the mechanisms of vitamin D action
  
• A new active vitamin D analog, ED-71, causes increase in bone mass with preferential effects on bone in osteoporotic
  
• Analogs of 1,25-dihydroxyvitamin D3 as pluripotent immunomodulators
  
• Effects of 1,25(OH)2D3 and its analogs on dendritic cell function
  
• Effects of 1,25-dihydroxyvitamin D3 on the distribution of androgen and vitamin D receptors
  
• Evidence for tissue- and cell-type selective activation of the vitamin D receptor
  
• Expression, structure-function, and molecular modeling of vitamin D P450s
  
• Inhibition of prostate cancer growth by vitamin D
  
• Inhibitors of vitamin D hydroxylases
  
• Intestinal calcium absorption- Molecular vitamin D mediated mechanisms
  
• Intranuclear trafficking of transcription factors- Requirements for mediated biological control of gene expression
  
• Mechanisms of intestinal calcium absorption
  
• Molecular basis of the selective activity of vitamin D analogues
  
• Novel regulators of vitamin D action and metabolism
  
• Prostatic 25-hydroxy1-hydroxylase and its implication in prostate cancer
  
• Rat cytochrome P450C24 (CYP24) does not metabolize 1,25-dihydroxyvitamin D2 to calcitroic acid
  
• Rationale for active vitamin D and analogs in the treatment of osteoporosis
  
• Regulation of 25-hydroxyvitamin D3-24-hydroxylase mRNA by 1,25-dihydroxyvitamin D3 and parathyroid hormone
  
• Role of the endocrine system in the pathophysiology of postmenopausal osteoporosis
  
• Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription
  
• Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases
  
• A millenium perspective
  
• Vitamin D and autoimmune diabetes
  
• Vitamin D and bone
  
• Vitamin D regulated keratinocyte differentiation
  
• Vitamin D regulation of the renin-angiotensin system
  
• Vitamin D target proteins- Function and regulation