Autoimmunity

       　自身免疫是机体免疫系统对自身成分发生免疫应答的现象。据估计,大约每31个美洲人中间就有一个人患自身免疫性疾病。到目前，已经有80种以上与自身免疫有关的疾病得到认识，这个数字还在增长，最好的例子是：在1983年发现磷脂抗体综合症。现在已经很清楚，免疫系统不仅在特定的免疫性病理过程中扮演关键角色，而且在许多其他疾病中通过炎症反应来发挥他的作用。目前，对于自身免疫的研究主要围绕自身免疫病展开，涉及各种自身免疫疾病机制和可能的治疗、预防方法。过去半个世纪的研究理解了免疫自身、自身与非自身的识别，以及正常自身耐受的机制，清晰了解从对自身成分无反应到自身免疫病的一系列事件。随着对决定免疫反应强弱的宿主遗传特点的进一步了解，识别出那些高敏感性的个例，有可能出现良性的抗原特异性干预法，从而为有效地预防自身免疫病带来光明的未来。为此CMBI特准备了关于Autoimmunity的特别报道，供实践参考。更多文献,请用相关关键词通过CMBI文献查询获取。

• Autoimmunity
  
• A causal link between lymphopenia and autoimmunity
  
• Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis
  
• An array of possibilities for the study of autoimmunity
  
• Apoptosis, subcellular particles, and autoimmunity
  
• Autoimmunity in Alzheimer’s disease
  
• Autoimmunity, anergy, lentiviral immunity and disease
  
• Beneficial autoimmunity in Type 1 diabetes mellitus
  
• Class switch recombination in B lymphopoiesis
  
• Control of autoimmunity by ‘epitope theft’
  
• C-reactive protein and autoimmunity
  
• Findings of inflammation and possible autoimmunity in calcific aortic stenosis
  
• Autoimmune heart failure
  
• Diverse pathways of cardiac allograft rejection correlate with distinct pathogenic mechanisms of cardiac-specific autoimmunity
  
• Influenza, autoimmunity and atherogenesis
  
• More sympathy for autoimmunity with neuropeptide Y
  
• Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome
  
• The transition from benign to pathogenic autoimmunity-the myocarditis
  
• Dendritic cells and the shadow line between autoimmunity and disease
  
• Design of effective immunotherapy for human autoimmunity
  
• diabetes-Prevention of diabetes by manipulation of anti-IGRP autoimmunity
  
• Gastric autoimmunity
  
• Helicobacter pylori and gastric autoimmunity
  
• Humoral autoimmunity against endothelium
  
• Inflamm-aging-autoimmunity, and the immune-risk phenotype
  
• Initiation of autoimmunity
  
• Interferon induced Autoimmune Thyroid Disease
  
• Limited clonality in autoimmunity
  
• Limited clonality in autoimmunity-
  
• Mast cells and autoimmunity
  
• Mechanisms of autoimmune hepatitis
  
• Mitochondrial hyperpolarization-a checkpoint of T-cell life, death and autoimmunity
  
• Paths to understanding the genetic basis of autoimmune disease
  
• Post-translational modifications of self antigens
  
• Pregnancy and autoimmunity
  
• Proteasomal processing of nuclear autoantigens in systemic autoimmunity
  
• Regulation of immunity by lysosphingolipids and their G protein-coupled receptors
  
• Regulation of immunity by self-reactive T cells
  
• Requirement for B lymphocytes in autoimmunity development
  
• Stem cell aging and autoimmunity in rheumatoid arthritis
  
• T cell immunity in hepatitis B and hepatitis C virus infection
  
• The new paradigm of T-cell homeostatic proliferation-induced autoimmunity
  
• The role of long-lived plasma cells in autoimmunity
  
• The scope of receptor editing and its association with autoimmunity
  
• Therapeutic manipulation of iNKT cells in autoimmunity
  
• Treatment of severe autoimmune disease by stem-cell transplantation
  
• Viruses as adjuvants for autoimmunity
  
• Yin–Yang regulation of autoimmunity by DCs
  
• A Deiminated Viral Peptide to Detect Antibodies in Rheumatoid Arthritis
  
• A Prospective Study of 1038 Pregnancies on the Predictive Value of Anti-Annexin V Antibodies for Fetal Loss
  
• Antibodies against Erythropoietin and Other Protein-Based Therapeutics
  
• Anti-C1q Autoantibodies in Lupus Nephritis
  
• Anti-Endothelial Cell Antibodies Determination by Cyto-ELISA
  
• Antinuclear Antibodies in Domestic Animals
  
• Cyclic Citrullinated Peptide Antibodies, Anti-Citrullin Antibodies, and IgM and IgA Rheumatoid Factors with Serological Parameters of Disease
  
• Autoimmune Nature of Influenza Atherogenicity
  
• Autoimmunity and Coxsackievirus Infection in Primary Sj?gren's Syndrome
  
• B Lymphocytes Are Required for Development and Treatment of Autoimmune Diseases
  
• BAFF Overexpression Is Associated with Autoantibody Production in Autoimmune Diseases
  
• Bovine Spongiform Encephalopathy, Multiple Sclerosis, and Creutzfeldt-Jakob Disease Are Probably Autoimmune Diseases
  
• Central Memory and Effector Memory Subsets of Human CD4+ and CD8+ T Cells Display Differential Sensitivity to TNF
  
• Clinical Utility of the Anti-CCP Assay
  
• Comparison of Different Test Systems for Simultaneous Autoantibody Detection in Connective Tissue Diseases
  
• Cross-Reactivity of IgM and IgG Anticardiolipin Antibodies with Oxidized-Low Density Lipoproteins
  
• Detection of TT Virus in Patients with Idiopathic Inflammatory Myopathies
  
• Determination of ANA Specificity Using the UltraPlexTM Platform
  
• Diagnostic Value of Anti-F-Actin Antibodies in a French Multicenter Study
  
• Differential Regulation of the IL-10 Gene in Th1 and Th2 T Cells
  
• DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic Hypermutation
  
• Effective Use of Autoantibody Tests in the Diagnosis of Systemic Autoimmune Disease
  
• Evaluation of a Novel Line-Blot Immunoassay for the Detection of Antibodies to Extractable Nuclear Antigens
  
• Evaluation of the BioPlexTM 2200 ANA Screen
  
• Expression and Reexpression of Recombination Activating Genes
  
• Functional Genomics in Early Autoimmunity
  
• Histo-Blood Group Antigens as Allo- and Autoantigens
  
• Human and Nonhuman Primate Lentiviral Infection and Autoimmunity
  
• Human Antiganglioside Autoantibodies
  
• Identification of Thrombin Antibodies in Patients with Antiphospholipid Syndrome
  
• IgE and FcRI Regulation
  
• Interspecific Structural Differences in Nucleosome as Revealed by Heteroimmunization in Mice with Human Nucleosome
  
• Long-Lived Plasma Cells and Their Contribution to Autoimmunity
  
• Multiplexed Immunoassay for Detection of Rheumatoid Factors by FIDISTM Technology
  
• Non-Antigen-Specific CD8+ T Suppressor Lymphocytes in Diseases Characterized by Chronic Immune
  
• Paraneoplastic Neurological Antibodies
  
• Plasticity in the positive selection of T cells
  
• Posttranslational Modifications of Self-Antigens
  
• Prevalence of Anticentromere F Protein Autoantibodies in 347 Patients with Non-Hodgkin's Lymphoma
  
• Prevalence of IgG Anti--Fodrin Antibodies in Sj?gren's Syndrome
  
• The Anti-Alpha-Actinin Test Completes Anti-DNA Determination in Systemic Lupus Erythematosus
  
• The Interaction of Pemphigus Autoimmunoglobulins with Epidermal Cells
  
• The Mechanism of Molecular Redundancy in Autoimmune Inflammation in the Context of CD44 Deficiency
  
• The Relevance of Autoantigen Source and Cutoff Definition in Antichromatin (Nucleosome) Antibody Immunoassays
  
• Value of a New Automated Fluorescence Immunoassay (EliA) for PR3 and MPO-ANCA in Monitoring Disease
  
• What Makes an Autoantigen an Autoantigen