心脏纤维化

       　纤维化是一种病理改变，通常是由于炎症或其他损伤导致的纤维结缔组织对器官的侵害，会严重影响器官的正常功能。心脏纤维化就是纤维结缔组织对心脏侵害的结果，其中主要是心内膜纤维化，以心内膜（通常是内三分之一）增厚为特征，左室最易被累及，因为纤维结缔组织缺乏弹性，所以会大大影响心脏的效能，可能会出现心脏肥大或充血性心衰。心脏纤维化亦可能继发于动脉硬化，此外任何可能导致冠状动脉供血不足的原因均有可能导致心脏纤维化。目前关于该问题的基础研究涉及：纤维化机制、心脏细胞的再生、心脏纤维化的预防和治疗以及相关疾病的分子和细胞机制研究。鉴于心脏纤维化的重要意义，CMBI特为大家准备了心脏纤维化的特别报道，供研究参考。更多文献,请用相关关键词通过CMBI文献查询获取。

• Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart
  
• Influence of cytokines and growth factors in ANG II-mediated collagen upregulation by fibroblasts in rats
  
• Eplerenone Prevents Salt-Induced Vascular Remodeling and Cardiac Fibrosis in Stroke-Prone SHR
  
• Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure
  
• Ultrasonic Backscatter and Serum Marker of Cardiac Fibrosis in Hypertensives
  
• type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts
  
• Tumor Necrosis Factor-–Induced AT1 Receptor Upregulation Enhances Angiotensin II–Mediated Cardiac Fibroblast Responses That Favor Fibrosis
  
• Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction
  
• The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
  
• The possible roles of mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase type 2 in cardiac fibrosis in the spontaneously hypertensive rat
  
• The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling
  
• Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering
  
• Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes
  
• Regulation of matrix metalloproteinases by cytokines and reactive oxygen-nitrogen species in the myocardium
  
• Reduction of Cardiac Fibrosis Decreases Systolic Performance Without Affecting Diastolic Function in Hypertensive Rats
  
• Quantitative analysis of the cardiac fibroblast transcriptome-implications for NO-cGMP signaling
  
• Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage
  
• Prolyl Oligopeptidase Is Involved in Release of the Antifibrotic Peptide Ac-SDKP
  
• Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis
  
• PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II
  
• Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes
  
• Pathophysiological findings in a model of persistent atrial fibrillation and severe congestive heart failure
  
• Norepinephrine-induced cardiac hypertrophy and fibrosis are not due to mast cell degranulation
  
• Norepinephrine Enhances Fibrosis Mediated by TGF-β in Cardiac Fibroblasts
  
• Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart
  
• Iron Overload Augments Angiotensin II–Induced Cardiac Fibrosis and Promotes Neointima Formation
  
• Inhibition of angiotensin converting enzyme (ACE) attenuates hypofibrinolysis and reduces cardiac perivascular fibrosis in genetically obese mice
  
• Impact of brief oxidant stress on primary adult cardiac fibroblasts
  
• Hypertensive myocardial fibrosis and diastolic dysfunction
  
• Hypertensive Myocardial Fibrosis and Diastolic Dysfunction
  
• Gene Expression in Fibroblasts and Fibrosis-Involvement in Cardiac Hypertrophy
  
• From Inflammation to Fibrosis
  
• Forestalling Fibrosis
  
• Essential biochemistry and physiology of (NT-pro)BNP
  
• EPLERENONE, BUT NOT STEROID WITHDRAWAL, REVERSES CARDIAC FIBROSIS
  
• Direct Actions of Urotensin II on the Heart-Implications for Cardiac Fibrosis and Hypertrophy
  
• Determinants and consequences of atrial fibrosis in patients undergoing open heart surgery
  
• Degree of cardiac fibrosis and hypertrophy at time of implantation predicts myocardial improvement during left ventricular assist device support
  
• Chymase Inhibition Prevents Cardiac Fibrosis and Improves Diastolic Dysfunction in the Progression of Heart Failure
  
• Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats
  
• Cellular cardiomyoplasty
  
• Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure
  
• Cardiac Myocyte-Specific Excision of the Integrin Gene Results in Myocardial Fibrosis
  
• Cardiac Angiotensin II Type 2 Receptor Activates the Kinin-NO System and Inhibits Fibrosis
  
• B-Type Natriuretic Peptide Exerts Broad Functional Opposition to Transforming Growth Factor-β in Primary Human Cardiac Fibroblasts
  
• Blockade of beta 1-and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis
  
• Alpha8beta1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium
  
• adm-Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage
  
• Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction
  
• Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension
  
• in left atrial tissue of patients with atrial fibrillation
  
• Connective tissue growth factor––a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure
  
• fibroblasts, cells that are critical for tissue repair and remodeling
  
• Post-Ischemic Myocardial Fibrosis Occurs Independent Of Hemodynamic Changes
  
• Cv-Fibrosis Of The Left Atria During Progression Of Heart Failure Is Increased Matrix Metalloproteinases
  
• Factors Involved in the Regulation of Type I Collagen Gene Expression-Implication in Fibrosis
  
• Transforming Growth Factor-beta Function Blocking Prevents Myocardial Fibrosis
  
• Left ventricular hypertrophy-a new approach for fibrosis inhibition
  
• Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension
  
• TIMP-1-A Marker of Left Ventricular Diastolic Dysfunction and Fibrosis in Hypertension
  
• Norepinephrine Enhances Fibrosis Mediated by TGF-beta in Cardiac Fibroblasts
  
• N-Acetyl-Ser-Asp-Lys-Pro Inhibits Phosphorylation of Smad2 in Cardiac Fibroblasts