干细胞生物学

       　2004年9月16日至19日，在美国爱荷华州立大学的Ames校区召开了增长因子与信号转导讨论会的第十三届年会，并刊出了“干细胞生物学－发育与可塑性”专辑。 近年来，干细胞在科研、临床、及公众领域产生了广泛影响。此次干细胞生物学研讨会对发育生物学、生物技术、及生物医学领域表现了很大兴趣。干细胞不仅为我们提供了研究发育的机会，而且为受损或疾病器官和组织修复提供了分离、维持、操作胚胎和组织干细胞的手段。过去十年取得的大量研究成果，丰富了我们对干细胞及其可塑性在中枢神经系统及其它组织的了解。此次会议分六个专题，包括干细胞生物学调节因子、细胞命运的决定因素、干细胞内在决定因子、干细胞转化等。 为此CMBI特搜集了关于干细胞生物学 的特别报道，供实践参考,更多文献,请用相关关键词"SC－"通过CMBI文献查询获取。

Part I. Regional Determinants of Cell Fate:
• Oxygen in the Cultivation of Stem Cells
• DNA Damage-Induced Programmed Cell Death: Potential Roles in Germ Cell Development

 

Part II. Intrinsic Determinants of Stem Cells:

• G Protein-Coupled Receptor Roles in Cell Migration and Cell Death Decisions
• Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films
• Cellular and Molecular Regulation of Hematopoietic and Intestinal Stem Cell Behavior
• The Function of the Neuronal Proteins Shc and Huntingtin in Stem Cells and Neurons: Pharmacologic Exploitation for Human Brain Diseases
• Engineering a Dopaminergic Phenotype in Stem/Precursor Cells: Role of Nurr1, Glia-Derived Signals, and Wnts

 

Part III. Transdifferentiation:
• Umbilical Cord Blood-Derived Stem Cells and Brain Repair
• Infusion of Human Umbilical Cord Blood Ameliorates Neurologic Deficits in Rats with Hemorrhagic Brain Injury
• How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow

 

Part IV. Stem Cell Responses to Perturbation:
• Human Retinal Progenitor Cells Grown as Neurospheres Demonstrate Time-Dependent Changes in Neuronal and Glial Cell Fate Potential
• Neural Progenitor Cell Transplants into the Developing and Mature Central Nervous System
• Stem Cells for Retinal Degenerative Disorders
• Magnetic Resonance Tracking of Implanted Adult and Embryonic Stem Cells in Injured Brain and Spinal Cord
• The Miniature Pig as an Animal Model in Biomedical Research

 

Part V. Reciprocal Communication between Graft and Host:
• Graft/Host Relationships in the Developing and Regenerating CNS of Mammals
• Grafted Neural Stem Cells Shield the Host Environment from Oxidative Stress
• Administration of Allogenic Stem Cells Dosed to Secure Cardiogenesis and Sustained Infarct Repair