造血干细胞

       　造血干细胞（Hematopoietic stem cell）就是各种血细胞的前体细胞。每天人体都产生大量新的白细胞、红细胞和血小板以补充正常或疾病、创伤所致的损失。多种造血机制允许血细胞产生以迅速应对出血或感染等应激反应。造血作用就是一系列血细胞的产生和稳态。理解了造血干细胞的主要生物学特点和造血的主要机制和过程对于治疗血液病、先天异常、化疗相关的血细胞减少以及血液和骨髓的移植有重要意义。此外造血干细胞分化为其他体细胞的能力（除了能分化为血细胞外）为医学领域的应用带来了光明的前景，因此是目前被关注的热点。为此CMBI特准备了 造血干细胞的特别报道，此外我们曾在特别报道之第120、113、109、39和第10期有过相关报道，敬请参阅。 更多文献，请用相关关键词通过CMBI文献查询获取。

• Primitive adult hematopoietic stem cells can function as osteoblast precursors
  
• Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates
  
• Unexpected Potential of Adult Stem Cells
  
• Transplanted Human Cord Blood Cells Give Rise to Hepatocytes in Engrafted Mice
  
• Thrombopoietin Is Essential for the Maintenance of Normal Hematopoiesis in Humans
  
• Thrombopoietin-Accumulating Evidence for an Important Biological Effect on the Hematopoietic Stem Cell
  
• The Mesenchymal Stroma Negatively Regulates B Cell Lymphopoiesis through the Expression of Activin A
  
• Telomeres in Hematopoietic Stem Cells
  
• Telomere Length Deficit in Normal Hematopoietic Stem Cells from Patients with Chronic Myeloid Leukemia
  
• Pluripotent Stem Cells Identified in Multiple Murine Tissues
  
• Nonpeptide Mediators in the Hematopoietic Microenvironment
  
• New Models to Investigate Mechanisms of Disease Genesis from Primitive BCR-ABL+ Hematopoietic Cells
  
• Mesenchymal Stem Cells and Hematopoietic Stem Cell Transplantation
  
• Marrow Stem Cell Potential within a Continuum
  
• Major Age-Related Changes Of Mouse Hematopoietic Stem-Progenitor Cells
  
• Identification, Characterization, and Function of a Novel Oncogene
  
• Hematopoietic Stem Cell Transplantation across Major Genetic Barriers
  
• Hematopoietic Stem Cell Emergence in the Human Embryo and Fetus
  
• From Embryos to Embryoid Bodies-Generating Blood from Embryonic Stem Cells
  
• Efficient Characterization of Retro-, Lenti-, and Foamyvector-Transduced Cell Populations by High-Accuracy Insertion Site Sequencing
  
• Early Stages of Hematopoietic Differentiation
  
• Differesntial Gene Expression Underlying the Functional Distinctions of Primary Human CD34+ Hematopoietic Stem and Progenitor Cells from Peripheral Blood and Bone Marrow
  
• Development of Gene Therapy for Hemoglobin Disorders
  
• Complement-Fixing CD45 Monoclonal Antibodies to Facilitate Stem Cell Transplantation
  
• Characterization of Cord Blood Hematopoietic Stem Cells
  
• CDCP1 Is a Novel Marker for Hematopoietic Stem Cells
  
• Biology and Plasticity of CD133+ Hematopoietic Stem Cells
  
• Antibody W7C5 Defines a CD109 Epitope Expressed on CD34+ and CD34-Hematopoietic and Mesenchymal Stem Cell Subsets
  
• Angiogenic Factors Reconstitute Hematopoiesis by Recruiting Stem Cells from Bone Marrow Microenvironment
  
• Adult Bone Marrow Stem Cells Regenerate Myocardium in Ischemic Heart Disease
  
• Hematopoietic stem cell
  
• Contribution of hematopoietic stem cells to skeletal muscle
  
• Self-Renewal And Lineage Restriction Of Hematopoietic Stem Cells
  
• Regulation Of Hematopoietic Stem Cell Self-Renewal
  
• Ontogenic Emergence Of Definitive Hematopoietic Stem Cell
  
• In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
  
• Can Old Cells Learn New Tricks
  
• Hematopoietic stem cell gene therapy, selecting only the best
  
• Experimental Basis Of Hematopoietic Stem Cell Transplantation For Treatment Of Autoimmune Diseases
  
• Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein
  
• Molecular Diagnostics-Pcr For The Diagnosis Of Toxoplasmosis After Hematopoietic Stem Cell Transplantation
  
• Therapy-Combating Infections In Hematopoietic Stem Cell
  
• Plasticity Of Hematopoietic Stem Cells And Cellular Memory
  
• Hematopoietic Stem Cells And Their Precursors
  
• Biology Of Hematopoietic Stem Cells And Progenitors
  
• IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation
  
• Current Research And Practice-Sc-Therapeutic Applications Of Non-Myeloablative Hematopoietic Stem Cell Transplantation In Malignant Disease
  
• Current Research And Practice-Sc-The Transplantation Of Hematopoietic Stem Cells After Non-Myeloablative Conditioning
  
• Recombinant Sendai Virus Provides-Highly Efficient Gene Transfer Into Human Cord Blood-Derived Hematopoietic Stem Cells
  
• American Society Of Gene Therapy (Asgt) Ad Hoc Subcommittee On Retroviral-Mediated Gene Transfer To Hematopoietic Stem Cells
  
• As-Advances In Retroviral Transduction Of Hematopoietic Stem Cells For The Gene Therapy Of Atherosclerosis
  
• Hematopoietic Stem Cells And Hematopoiesis
  
• Autologous Hematopoietic Stem Cell Transplant In First Remission In Non-Hodgkin?ˉs Lymphoma
  
• Acute Lymphocytic Leukemia-Role Of Hematopoietic Stem Cell Transplantation In Current Management
  
• The Graft Versus Leukemia Response After Allogeneic Hematopoietic Stem Cell Transplantation
  
• Hematopoietic Stem Cell Transplantation In Sickle Cell Disease
  
• Nonmyeloablative Therapy And Allogeneic Hematopoietic Stem Cell Transplantation
  
• Hematopoietic Stem Cells Engraft In Mice With Absolute Efficiency
  
• Maximizing optimal hematopoietic stem cell donor selection
  
• Maximizing optimal hematopoietic stem cell donor selection from registries of unrelated adult volunteers
  
• Manipulating hematopoietic stem cell amplification with Wnt
  
• Intensive care support and Acute Physiology and Health Evaluation in hematopoietic stem cell
  
• A stromal cell-Cderived membrane protein that supports hematopoietic stem cells
  
• Infusion of donor-derived hematopoietic stem cells in organ transplantation-clinical data
  
• Donor-derived hematopoietic stem cells in organ transplantation
  
• Hepatic Veno-occlusive Disease After Hematopoietic Stem Cell Transplantation
  
• Hematopoietic stem cells-from the bone to the bioreactor
  
• regeneration-Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization
  
• regeneration-Hepatic regeneration from hematopoietic stem cells
  
• Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells
  
• Interleukin-3 Promotes Proliferation and Differentiation of Human Hematopoietic Stem Cells
  
• The Third Conference on Hematopoietic Stem Cell Gene Therapy
  
• Continuous Intravascular Secretion of Endostatin in Mice from Transduced Hematopoietic Stem Cells
  
• Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy
  
• Disruption of the CXCR4-CXCL12 chemotactic interaction during hematopoietic stem cell mobilization
  
• autoimmu-Hematopoietic stem cell therapy for type 1 diabetes-induction of tolerance and islet cell neogenesis
  
• autoimmu-Autologous hematopoietic stem cell transplantation for Crohn's disease
  
• Liver-Specific Gene Expression in Cultured Human Hematopoietic Stem Cells
  
• CD34-Hematopoietic Stem Cells-Current Concepts and Controversies
  
• Stem cells and lineage plasticity-Plasticity of hematopoietic stem cells and cellular memory
  
• Stem cells and lineage plasticity-Hematopoietic stem cells and their precursors
  
• Epstein-Barr virus-Allogeneic hematopoietic stem cell transplantation for Epstein-Barr virus-associated T-NK-cell lymphoproliferative disease
  
• Atherogenesis in perspective-Hematopoietic stem cells differentiate into vascular cells that participate in atherosclerosis
  
• The Ly-6A (Sca-1) GFP Transgene is Expressed in all Adult Mouse Hematopoietic Stem Cells
  
• Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
  
• Hematopoietic Stem Cells from Fancc-Mice Have Lower Growth and Differentiation Potential in Response to Growth Factors
  
• Ex vivo expansion of hematopoietic stem cells by cytokines
  
• Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
  
• A molecular profile of a hematopoietic stem cell niche
  
• Second Hematopoietic Stem Cell Transplantation in Pediatric Patients
  
• Fetal Hematopoietic Stem Cell Transplantation
  
• plasticity of stem cells-Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation
  
• plasticity of stem cells-Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation
  
• plasticity of stem cells-A novel dynamic model of hematopoietic stem cell organization based on the concept of within-tissue plasticity
  
• Stem cell biology and gene therapy-Post-transduction events in retrovirus-mediated gene Therapy Involving Hematopoietic Stem Cells-Beyond Efficiency Issues
  
• Stem cell biology and gene therapy-Obstacles to human hematopoietic stem cell transduction by Recombinant Adeno-Associated Virus 2 Vectors
  
• Stem cell biology and gene therapyHematopoietic stem cell gene therapy for inherited Bone Marrow Disorders-Past Accomplishments and Continued Challenges
  
• Plasticity of hematopoietic stem cells-Enough to induce tolerance and repair tissue
  
• edu-Preventing Opportunistic Infections After Hematopoietic Stem Cell Transplantation
  
• Hematopoietic stem cell transplantation in Hodgkin disease
  
• Thrombopoietin expands hematopoietic stem cells after transplantation
  
• Purification and Functional Assay of Pluripotent Hematopoietic Stem Cells
  
• PERIPHERAL BLOOD STEM CELL TRANSPLANTATION-RESULTS OF UNRELATED UMBILICAL CORD BLOOD HEMATOPOIETIC STEM CELL TRANSPLANTATION
  
• Optimizing hematopoietic stem cell engraftment-a novel role for thrombopoietin
  
• Normal and Leukemic CD34-negative Human Hematopoietic Stem Cells
  
• Hematopoietic stem cell therapy for type 1 diabetes
  
• Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells
  
• Can Human Hematopoietic Stem Cells Become Skin, Gut, or Liver Cells
  
• Diffuse Alveolar Hemorrhage in Hematopoietic Stem Cell Transplant Recipients
  
• autoimm-Hematopoietic stem cell therapy for type 1 diabetes
  
• Stem cell and gene therapy-Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells
  
• Stem cell and gene therapy-Obstacles to human hematopoietic stem cell transduction by recombinant adeno-associated virus 2 vectors
  
• Stem cell and gene therapy-Hematopoietic stem cell gene therapy for inherited bone marrow disorders
  
• Third Conference on Hematopoietic Stem Cell Gene Therapy-Biology and Technology
  
• Stem cell biology and gene therapy-Post-transduction events in retrovirus-mediated gene therapy involving hematopoietic stem cells
  
• Stem cell biology and gene therapy-Obstacles to human hematopoietic stem cell transduction by recombinant adeno-associated virus 2 vectors
  
• Stem cell biology and gene therapy-Hematopoietic stem cell gene therapy for inherited bone marrow disorders
  
• Gene Therapy of Hematopoietic Stem Cells-Strategies for Improvement
  
• rheumatoid arthritis-High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis
  
• sc-Second malignancies after allogeneic new insight and current problems
  
• The aging of lympho-hematopoietic stem cells
  
• Hematopoietic Stem Cells Focus
  
• Telomeres, X-Inactivation Ratios, and Hematopoietic Stem Cell Transplantation in Humans
  
• Hematopoietic Stem Cells Localize to the Endothelial Cell Layer
  
• Telomeres, X-Inactivation Ratios, and Hematopoietic Stem Cell Transplantation in Humans
  
• Differential regulation of the human and murine CD34 genes in hematopoietic stem cells
  
• Endothelia-Multiple organ dysfunction syndrome in hematopoietic stem cell transplantation
  
• Purging in autologous hematopoietic stem cell transplantation using adenosine triphosphate
  
• Lentiviral vector?Cmediated transduction of murine CD34? hematopoietic stem cells
  
• HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo
  
• Hematopoietic stem cell transplantation in Hodgkin disease
  
• Hematopoietic stem cells differentiate into vascular cells that participate in atherosclerosis
  
• Therapeutic applications for hematopoietic stem cell gene transfer
  
• Hematopoietic stem cells for transplantation
  
• aging of lympho-hematopoietic stem cells
  
• Hematopoietic stem cells differentiate into vascular cells that participate in atherosclerosis
  
• Muscle-derived hematopoietic stem cells are hematopoietic in origin
  
• Trends in transplantation of hematopoietic stem cells from unrelated donors
  
• The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation
  
• Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem cells
  
• Nonablative allogeneic hematopoietic stem cell transplantation
  
• Lymphocyte development from hematopoietic stem cells
  
• Hematopoietic stem cell transplantation
  
• Flk-2 is a marker in hematopoietic stem cell differentiation-A simple method to isolate long-term stem cells
  
• Preventing Opportunistic Infections After Hematopoietic Stem Cell Transplantation
  
• Umbilical cord blood transplants
  
• Trends in transplantation of hematopoietic stem cells from unrelated donors
  
• Transplantation hematopoiesis
  
• Role of mesenchymal stem cells in hematopoietic stem cell transplantation
  
• Reducing transplant toxicity
  
• Issues in the manufacture and transplantation of genetically modified hematopoietic stem cells
  
• Hematopoietic stem cell transplantation
  
• Developments in T-cell depletion of allogeneic stem cell grafts
  
• Correction of genetic blood defects by gene transfer
  
• Conditioning regimens for allogeneic stem cell transplants
  
• Cellular therapy-exploiting NK cell alloreactivity in transplantation
  
• Cellular therapy-donor lymphocyte infusion
  
• Bone marrow or peripheral blood as a source of stem cells for allogeneic transplants
  
• Acute myeloid leukemia-therapeutic indications
  
• Hematopoietic stem cell transplantation2
  
• Hematopoietic growth factors-Role of thrombopoietin in hematopoietic stem cell and progenitor regulation
  
• Immune reconstitution after hematopoietic stem cell transplantation: gaining experience without losing naivety
  
• The role of apoptosis in regulating hematopoietic stem cell numbers
  
• Hematopoietic stem cell transplantation in patients with myelodysplastic syndrome
  
• Treatment of autoimmune diseases by hematopoietic stem cell transplantation
  
• Treatment of autoimmune diseases by hematopoietic stem cell transplantation
  
• Multispectral Marking and Lineage Analysis of Hematopoietic Stem Cells
  
• Pluripotent hematopoietic stem cell development during embryogenesis
  
• Hematopoietic stem cell-old and new
  
• Rainbow Reporters for Multispectral Marking and Lineage Analysis of Hematopoietic Stem Cells
  
• Pluripotent hematopoietic stem cell development during embryogenesis
  
• Hematopoietic Stem Cell Transplantation
  
• Standardization of hematopoietic stem cell assays
  
• Autonomous behavior of hematopoietic stem cells
  
• An improved method of hematopoietic stem cell
  
• The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression
  
• Current status of umbilical cord blood hematopoietic stem cell transplantation
  
• The future of allogeneic hematopoietic stem cell transplantation
  
• Consequences of BCR-ABL Expression within the Hematopoietic Stem Cell in Chronic Myeloid Leukemia
  
• Tolerance and hematopoietic stem cell transplantation 50 years after Burnet's theory
  
• GENE TRANSFER TO HEMATOPOIETIC STEM CELLS
  
• Evidence of Peripheral Blood-Derived, Plastic-Adherent CD34¨C-low Hematopoietic Stem Cell Clones with Mesenchymal Stem Cell Characteristics
  
• Tolerance and hematopoietic stem cell transplantation 50 years after Burnet's theory
  
• The Genetic Program of Hematopoietic Stem Cells
  
• The future of allogeneic minimizing pain, maximizing gain
  
• Self renewal, differentiation or death regulation and manipulation of hematopoietic stem cell fate
  
• A Role for Hematopoietic Stem Cells in Promoting Angiogenesis
  
• Self-renewal, differentiation or death- regulation and manipulation of hematopoietic stem cell fate
  
• Hematopoietic stem cells Are they CD34-positive or CD34-negative
  
• Hematopoietic Stem Cell Transplantation
  
• Hematopoietic Stem Cells Need Two Signals to Prevent Apoptosis; BCL-2 Can Provide One of These, Kitl c-Kit Signaling the Other
  
• Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
  
• Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection
  
• Role of Natural Killer Cell Alloreactivity in HLA-Mismatched Hematopoietic Stem Cell Transplantation
  
• Self renewal, differentiation or death:regulation and manipulation of hematopoietic stem cell fate
  
• Reversal of Diabetes in the Rat by Injection of Hematopoietic Stem Cells Infected With Recombinant Adeno-Associated Virus Containing the Preproinsulin II Gene
  
• Recent progress in gene transfer into hematopoietic stem cells
  
• In utero hematopoietic stem cell transfer: current status and future strategies
  
• Hematopoietic stem cell gene therapy for Niemann-Pick disease and other lysosomal storage diseases
  
• Distinct actions of interleukin-9 and interleukin-4 on a hematopoietic stem cell line, EMLC1
  
• Functional activity of murine CD34+ and CD34- hematopoietic stem cell populations
  
• Pluripotent, cytokine-dependent, Hematopoietic Stem Cells
  
• The Genetic Program of Hematopoietic Stem Cells
  
• Mechanisms Mediating the Inhibitory Effect of All-Trans Retinoic Acid on Primitive Hematopoietic Stem Cells in Human Long-Term Bone Marrow Culture