HEMATOPOIETIC STEM CELLS

       　近来，在阐明干细胞在诱导分化时表现出的滋生维持及其相应方式的机理方面取得了快速的进展，这些发现最终对于治疗某些白血病可能有重要意义。同时近来干细胞生物学出现了一个吸引人但又引起广泛争议的研究领域——转分化（transdifferentiation）研究，有朝一日这个方法学可能应用于鉴定细胞周期的各阶段。此外，对于阐明转录因子在维持造血干细胞分化所起的作用方面也取得了一定的进展。为此CMBI特搜集了关于HEMATOPOIETIC STEM CELLS 的特别报道，供实践参考,更多文献,请用相关关键词通过CMBI文献查询获取。

Part I. Malignant Hematopoiesis:
• Acute Myeloid Leukemia Stem Cells
• Control of Self-Renewal and Differentiation of Hematopoietic Stem Cells HOXB4 on the Threshold
• Developmental Impact of Leukemic Fusion Genes on Stem Cell Fate

 

Part II. Early Hematopoiesis:
• Derivation of the Hematopoietic Stem Cell Compartment from Human Embryonic Stem Cell Lines
• Thrombopoietin Regulates Differentiation of Rhesus Monkey Embryonic Stem Cells to Hematopoietic Cells
• The Vascular Wall as a Source of Stem Cells
• Genetic and Functional Characterization of Isolated Stromal Cell Lines from the Aorta-Gonado-Mesonephros Region

 

Part III. Mobilization:
• Involvement of Proteases in Cytokine-Induced Hematopoietic Stem Cell Mobilization
• Hematopoietic Stem Cell Transplantation across Major Genetic Barriers
• The Role of Sphingosine 1-Phosphate Receptors in the Trafficking of Hematopoietic Progenitor Cells

 

Part IV. Gene Expression in Stem Cells:
• Epigenetic Regulation of Normal and Cancer Stem Cells
• Distinct Gene Expression Pattern of Malignant Hematopoietic Stem and Progenitor Cells in Polycythemia Vera
• Hox Genes From Leukemia to Hematopoietic Stem Cell Expansion

 

Part V. Plasticity:
• Engraftment of Bone Marrow-Derived Epithelial Cells
• Lineage Promiscuity and Plasticity in Hematopoietic Development
• Stem Cell Biology A View toward the Future

 

Part VI. Regulators:
• Thrombopoietin and the Hematopoietic Stem Cell
• Role of GATA-1 in Normal and Neoplastic Hemopoiesis
• Gene Expression in Stem Cell-Supporting Stromal Cell Lines
• Effect of Tyrosine Kinase Inhibition Using Imatinib on Normal Lymphohematopoietic Cells

 

Part VII. Clonality:
• Stem Cell Gene Transfer Insights into Integration and Hematopoiesis from Primate Genetic Marking Studies
• Clonal Multilineage Differentiation of Murine Common Pluripotent Stem Cells Isolated from Skeletal Muscle and Adipose Stromal Cells
• Tracking Hematopoiesis at the Single Cell Level
• Lymphoid Potential of Primitive Bone Marrow Progenitors Evaluated In Vitro

 

Part VIII. Self-Renewal:
• Role of Telomerase in Hematopoietic Stem Cells
• The Stem Cell Continuum
• Human Adaptive Immune System Rag2––c–– Mice