线粒体在衰老和疾病中的作用

       　线粒体是重要的细胞器，它不仅在细胞的能量代谢中起着重要作用，而且与细胞生长、损伤和凋亡，亦有着密切的关系。线粒体基因、结构和功能异常不仅与衰老有关，而且可以参与肿瘤、心血管病、糖尿病、代谢综合症和神经退行性病等许多疾病的发病。因此，受到国际广泛的关注。2004年4月在台北召开了第二次线粒体与疾病国际会议，现将有关线粒体在衰老和疾病中的作用的综述报告如下，以供大家参考。更多的全文文献，请用mitochondria关键词通过CMBI文献查询获取。

Part I. Mitochondrial Disease Models:
• Mitochondria-Based Model for Fetal Origin of Adult Disease and Insulin Resistance
• Evolutional Analysis in Determining Pathogenic versus Nonpathogenic Mutations of ATPase 6 in Human Mitochondriopathy
• Restoration of Mitochondrial Function in Cells with Complex I Deficiency
• Hearing Loss in Mitochondrial Disorders
• Brain Single Photon Emission Computed Tomography in Patients with A3243G Mutation in Mitochondrial DNA tRNA
• Upregulation of Matrix Metalloproteinase 1 and Disruption of Mitochondrial Network in Skin Fibroblasts of Patients with MERRF Syndrome
• Increased Oxidative Damage with Altered Antioxidative Status in Type 2 Diabetic Patients Harboring the 16189 T to C Variant of Mitochondrial DNA
• Alteration of the Copy Number of Mitochondrial DNA in Leukocytes of Patients with Hyperlipidemia
• A New Noninvasive Test to Detect Mitochondrial Dysfunction of Skeletal Muscles in Progressive Supranuclear Palsy
• High Prevalence of the COIItRNALys Intergenic 9-bp Deletion in Mitochondrial DNA of Taiwanese Patients with MELAS or MERRF Syndrome

 

Part II. Mitochondrial Genome:

• Analysis of Proteome Bound to D-Loop Region of Mitochondrial DNA by DNA-Linked Affinity Chromatography and Reverse-Phase Liquid ChromatographyTandem Mass Spectrometry
• Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA
• Mitochondrial Genome Instability and mtDNA Depletion in Human Cancers
• Frequent Occurrence of Mitochondrial Microsatellite Instability in the D-Loop Region of Human Cancers
• Analysis of Heteroplasmy in Hypervariable Region II of Mitochondrial DNA in Maternally Related Individuals
• Deleted Mitochondrial DNA in Human Luteinized Granulosa Cells
• Identification of Human-Specific Adaptation Sites of ATP6

 

Part III. Mitochondrial Function:
• Repeated Ovarian Stimulations Induce Oxidative Damage and Mitochondrial DNA Mutations in Mouse Ovaries
• Calcium Stimulates Mitochondrial Biogenesis in Human Granulosa Cells
• Dynamics of Mitochondria and Mitochondrial Ca2+ near the Plasma Membrane of PC12 Cells
• Propofol Specifically Inhibits Mitochondrial Membrane Potential but Not Complex I NADH Dehydrogenase Activity, Thus Reducing Cellular ATP Biosynthesis and Migration of Macrophages
• Abnormal Mitochondrial Structure in Human Unfertilized Oocytes and Arrested Embryos
• Oxidative Damage and Mitochondrial DNA Mutations with Endometriosis
• Neuroprotective Role of Coenzyme Q10 against Dysfunction of Mitochondrial Respiratory Chain at Rostral Ventrolateral Medulla during Fatal Mevinphos Intoxication in the Rat

 

Part IV. Oxidative Stress:
• Mitochondrial Dysfunction and Oxidative Stress as Determinants of Cell DeathSurvival in Stroke
• Oxidative Damage in Mitochondrial DNA Is Not Extensive
• Enhanced Generation of Mitochondrial Reactive Oxygen Species in Cybrids Containing 4977-bp Mitochondrial DNA Deletion
• S-Nitrosoglutathione and Hypoxia-Inducible Factor-1 Confer Chemoresistance against Carbamoylating Cytotoxicity of BCNU in Rat C6 Glioma Cells
• Celecoxib Induces Heme-Oxygenase Expression in Glomerular Mesangial Cells
• Oxidative Stress-Induced Depolymerization of Microtubules and Alteration of Mitochondrial Mass in Human Cells
• Blood Lipid Peroxides and Muscle Damage Increased following Intensive Resistance Training of Female Weightlifters
• Anti-Inflammatory and Antioxidative Effects of Propofol on Lipopolysaccharide-Activated Macrophages
• Protective Effect of-Keto-β-Methyl-n-Valeric Acid on BV-2 Microglia under Hypoxia or Oxidative Stress
• Oxidative Toxicity in BV-2 Microglia Cells
• Angiotensin II Stimulates Hypoxia-Inducible Factor 1 Accumulation in Glomerular Mesangial Cells
• Effects of Glucose and-Tocopherol on Low-Density Lipoprotein Oxidation and Glycation
• Identification of Three Mutations in the Cu,Zn-Superoxide Dismutase (Cu,Zn-SOD) Gene with Familial Amyotrophic Lateral Sclerosis
• Kainic Acid-Induced Oxidative Injury Is Attenuated by Hypoxic Preconditioning
• Antioxidant N-Acetylcysteine Blocks Nerve Growth Factor-Induced H2O2ERK Signaling in PC12 Cells

 

Part V. Antioxidants:
• Effect of Enhanced Prostacyclin Synthesis by Adenovirus-Mediated Transfer on Lipopolysaccharide Stimulation in Neuron-Glia Cultures
• Potential Mechanism of Blood Vessel Protection by Resveratrol, a Component of Red Wine
• Pravastatin Attenuates Ceramide-Induced Cytotoxicity in Mouse Cerebral Endothelial Cells with HIF-1 Activation and VEGF Upregulation
• Alleviation of Oxidative Damage in Multiple Tissues in Rats with Streptozotocin-Induced Diabetes by Rice Bran Oil Supplementation
• Curcumin Inhibits ROS Formation and Apoptosis in Methylglyoxal-Treated Human Hepatoma G2 Cells
• Prevention of Cellular Oxidative Damage by an Aqueous Extract of Anoectochilus formosanus
• Inhibitory Effects of a Rice Hull Constituent on Tumor Necrosis Factor , Prostaglandin E2, and Cyclooxygenase-2 Production in Lipopolysaccharide-Activated Mouse Macrophages
• Raffinee in the Treatment of Spinal Cord Injury

 

Part VI. Apoptosis:
• Induction of Thioredoxin and Mitochondrial Survival Proteins Mediates Preconditioning-Induced Cardioprotection and Neuroprotection
• Mitochondrion-Targeted Photosensitizer Enhances the Photodynamic Effect-Induced Mitochondrial Dysfunction and Apoptosis
• Attenuation of UV-Induced Apoptosis by Coenzyme Q10 in Human Cells Harboring Large-Scale Deletion of Mitochondrial DNA
• Antisense RNA to Inducible Nitric Oxide Synthase Reduces Cytokine-Mediated Brain Endothelial Cell Death
• 2,6-Diisopropylphenol Protects Osteoblasts from Oxidative Stress-Induced Apoptosis through Suppression of Caspase-3 Activation
• Nitric Oxide Induces Osteoblast Apoptosis through a Mitochondria-Dependent Pathway
• Bcl-2 Gene Family Expression in the Brain of Rat Offspring after Gestational and Lactational Dioxin Exposure
• IL-5 Inhibits Apoptosis by Upregulation of c-myc Expression in Human Hematopoietic Cells
• Detection of Apoptosis and Necrosis in Normal Human Lung Cells Using 1H NMR Spectroscopy
• Cadmium Toxicity toward Caspase-Independent Apoptosis through the Mitochondria-Calcium Pathway in mtDNA-Depleted Cells
• Pectinesterase Inhibitor from Jelly Fig (Ficus awkeotsang Makino) Achene Induces Apoptosis of Human Leukemic U937 Cells
• Enhancement of Cisplatin-Induced Apoptosis and Caspase 3 Activation by Depletion of Mitochondrial DNA in a Human Osteosarcoma Cell Line
• Thallium Acetate Induces C6 Glioma Cell Apoptosis
• Effects of Gonadotrophin-Releasing Hormone Agonists on Apoptosis of Granulosa Cells