生物活性分子－H2S

       　以往观点认为，H2S仅仅是体内的代谢废气。近来，越来越多的研究显示，H2S可能是NO、CO之外的第三种气体信号分子。它作为新型气体信号分子，具有广泛的血管活性，如抑制平滑肌细胞增殖、抑制细胞色素氧化酶c活性、直接清除氧自由基、拮抗HCY诱导的线粒体氧自由基的产生等。为此CMBI特准备了关于生物活性分子－H2S的特别报道，供实践参考。更多文献,请用相关关键词通过CMBI文献查询获取。

• A novel cystathionine beta-synthase from Panagrellus redivivus
  
• A novel enhancing mechanism for hydrogen sulfide-producing activity of cystathionine beta-synthase
  
• Anaerobic sulfur metabolism in thiotrophic symbioses
  
• anions derived from underivatised peptides. The side-chain loss of H2S from Cys
  
• Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats
  
• Bismuth subsalicylate markedly decreases hydrogen sulfide release in the human colon
  
• Brain hydrogen sulfide is severely decreased in Alzheimer's disease
  
• Carbonyl sulfide and carbon dioxide as new substrates, and carbon disulfide as a new inhibitor, of nitrogenase
  
• Cloning and characterization of a gene cluster, phsBCDEF, necessary for the production of hydrogen sulfide from thiosulfate by Salmonella typhimurium
  
• Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1-2 phosphorylation and p21Cip-WAK-1
  
• Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation
  
• Determination of hydrogen sulfide and acid-labile sulfur in animal tissues by gas chromatography and ion chromatography
  
• Differential sensitivity of lung and brain to sulfide exposure
  
• Direct determination of molecular orbital symmetry of H2S using polarized x-ray emission
  
• Effects of hydrogen sulfide exposure on surface properties of lung surfactant
  
• Effects of hydrogen sulfide on neurobehavioral function
  
• Effects of repeated exposures of hydrogen sulphide on rat hippocampal
  
• Effects of repeated hydrogen sulphide (H2S) exposure on learning and memory in the adult rat
  
• Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules_an inventory for the origins of life
  
• Enzymatic hydrogen sulfide production in marine invertebrate tissues
  
• Evidence that hydrogen sulphide can modulate hypothalamo-pituitary-adrenal axis function
  
• fatality caused by accidental production of hydrogen sulfide
  
• Fecal hydrogen sulfide production in ulcerative colitis
  
• Fertility and developmental neurotoxicity effects of inhaled hydrogen sulfide in Sprague-Dawley rats
  
• Fragmentation dynamics of H2S following S 2p photoexcitation
  
• From O2 to H2S_a landscape view of gas biology
  
• Gas production by feces of infants
  
• Gastrointestinal and microbial responses to sulfate-supplemented drinking water in mice
  
• Glutathione-and glutathione-S-transferase-dependent oxidative desulfuration of the thione xenobiotic diethyldithiocarbamate methyl ester
  
• H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation
  
• H2S generated by heart in rat and its effects on cardiac function-
  
• H2S induces a suspended animation-like state in mice
  
• H2S-induced vasorelaxation and underlying cellular and molecular mechanisms
  
• Hemoglobin oxidation products extract phospholipids from the membrane of human erythrocytes
  
• Hydrogen sulfide (H2S) stimulates capsaicin-sensitive primary afferent neurons in the rat urinary bladder
  
• Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone
  
• Hydrogen sulfide consumption measured at low steady state concentrations using a sulfidostat
  
• Hydrogen sulfide exposure without loss of consciousness
  
• Hydrogen sulfide-from the smell of the past to the mediator of the future
  
• Hydrogen sulfide induces calcium waves in astrocytes
  
• Hydrogen sulfide induces serum-independent cell cycle entry in nontransformed rat intestinal epithelial cells
  
• Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse
  
• Hydrogen sulfide is produced in response to neuronal excitation
  
• Hydrogen sulfide poisoning-clarification of some controversial issues
  
• Hydrogen sulfide protects neurons from oxidative stress
  
• Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3
  
• Hyperhomocysteinemia_an additional cardiovascular risk factor
  
• Identification linker histone H1 as a protein kinase Cepsilon-binding protein in vascular smooth muscle
  
• Neurotoxicological effects associated with short-term exposure of Sprague-Dawley rats to hydrogen sulfide
  
• New roles for cysteine and transsulfuration enzymes-production of H2S, a neuromodulator
  
• Novel neural modulators
  
• Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle
  
• Physiological effects of hydrogen sulfide inhalation during exercise in healthy men
  
• Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues
  
• Polymorphisms of glutathione S-transferase M1 and T1 modulate blood pressure of individuals chronically exposed to natural sour gas containing sulfur compounds
  
• Potentiation by sulfide of hydrogen peroxide-induced killing of Escherichia coli
  
• Production and elimination of sulfur-containing gases in the rat colon
  
• Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine
  
• Reactions depending on iron sulfide and linking geochemistry with biochemistry
  
• Reactivity of carbon monoxide dehydrogenase from Rhodospirillum rubrum with carbon dioxide, carbonyl sulfide, and carbon disulfide
  
• Regulation of hydrogen sulfide liberation in wine-producing Saccharomyces
  
• Respiratory tract toxicity of inhaled hydrogen sulfide
  
• Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control
  
• Role of hydrogen sulfide in acute pancreatitis and associated lung injury
  
• Single eubacterial origin of eukaryotic sulfide-quinone oxidoreductase, a mitochondrial enzyme conserved
  
• Sulfide acquisition by the vent worm Riftia pachyptila appears to be via uptake of HS-, rather than H2S
  
• SULFUR AMINO ACID METABOLISM
  
• The novel neuromodulator hydrogen sulfide
  
• The possible role of hydrogen sulfide as an endogenous neuromodulator
  
• The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide
  
• The production of hydrogen sulfide is regulated by testosterone and S-adenosyl-L-methionine in mouse brain
  
• The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats-
  
• Toxicology of hydrogen sulfide
  
• Treatment of H2S using a horizontal biotrickling filter based on biological activated carbon
  
• Twenty-foot fall averts fatality from massive hydrogen sulfide exposure
  
• Two's company, three's a crowd-can H2S be the third endogenous gaseous transmitter
  
• Ultrastructural and morphometric characteristics of nerve cells and myelinated fibers in the cerebral cortex after chronic exposure to natural gas containing hydrogen sulfide in low concentrations
  
• Vertebrate phylogeny of hydrogen sulfide vasoactivity