Oncogene

       　癌基因是指其编码的产物与细胞的肿瘤性转化有关的基因。它以显性的方式作用，对细胞生长起阳性作用，并促进细胞转化。人类肿瘤中最常见的癌基因包括p53、 Ras、 Rb、myc等，它们是生物细胞基因组的正常成分，其编码的蛋白质参与调节正常细胞的生长与分化，在控制细胞增殖的信息转导途径中起作用。当它们被导入逆录病毒而活化成病毒癌基因，或因突变、或异常表达而活化成细胞癌基因后，则诱导细胞的异常增殖和肿瘤发生。为此CMBI特准备了关于Oncogene的特别报道，供实践参考。更多文献,请用相关关键词通过CMBI文献查询获取。

• The Runx genes
  
• The Runx genes as dominant oncogenes
  
• switching off oncogenes
  
• RNA polymerase III transcription-a battleground for tumour suppressors and oncogenes
  
• RET and NTRK1 proto-oncogenes in human diseases
  
• oncogenes in the Wnt signaling pathway
  
• Oncogenes in melanoma
  
• oncogenes as therapeutic targets
  
• Oncogenes as regulators of tissue factor expression in cancer
  
• Oncogenes and tumor suppressor genes in breast cancer
  
• Oncogenes and tumor angiogenesis
  
• Modeling the dosage effect of oncogenes in leukemogenesis
  
• The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis
  
• Understanding mesenchymal cancer-the liposarcoma-associated FUS–DDIT3 fusion gene as a model
  
• The EWS–WT1 gene fusion in desmoplastic small round cell tumor
  
• Fusion oncogenes in tumor development
  
• Fusion oncogenes and tumor type specificity—insights from salivary gland tumors
  
• ETV6–NTRK3-a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
  
• ETV6-A versatile player in leukemogenesis
  
• Context matters-The hen or egg problem in Ewing's sarcoma
  
• Fusion oncogenes
  
• ABL oncogenes and phosphoinositide 3-kinase
  
• Conditional animal models-a strategy to define when oncogenes will be effective targets to treat cancer
  
• versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis
  
• the liposarcoma-associated FUS–DDIT3 fusion gene as a model
  
• Identification of genes differentially regulated by the P210 BCR-ABL1 fusion oncogene using cDNA microarrays
  
• hen or egg problem in Ewing's sarcoma
  
• Fusion oncogenes in tumor development
  
• Fusion oncogenes and tumor type specificity
  
• EWS–WT1 gene fusion in desmoplastic small round cell tumor
  
• ETV6–NTRK3-a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
  
• ETV6-A versatile player in leukemogenesis
  
• Fusion oncogenes
  
• versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis
  
• Understanding mesenchymal cancer
  
• The hen or egg problem in Ewing's sarcoma
  
• The EWS–WT1 gene fusion in desmoplastic small round cell tumor
  
• Fusion oncogenes in tumor development
  
• Fusion oncogenes and tumor type specificity
  
• ETV6–NTRK3
  
• ETV6
  
• Fusion oncogenes
  
• p53 mutation profiling of multiple esophageal carcinoma using laser capture microdissection to demonstrate field carcinogenesis
  
• Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China
  
• Serum p53 and bladder cancer
  
• Mechanism of Induction of Apoptosis by p73 and Its Relevance to Neuroblastoma Biology
  
• Role of p53 in cisplatin-induced tubular cell apoptosis dependence on p53 transcriptional activity
  
• Clinical implications of p53 mutation analysis in bladder cancer tissue and urine sediment by functional assay in yeast
  
• High levels of p53 protein expression do not correlate with p53 mutations in hepatocellular carcinoma
  
• POST-TRANSLATIONAL MODIFICATION OF P53 IN TUMORIGENESIS
  
• p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours
  
• Human tumor suppressor p53 and DNA viruses
  
• Curcumin impairs tumor suppressor p53 function in colon cancer cells.
  
• An examination of sibling support in apoptosis control
  
• The common and distinct target genes of the p53 family transcription factors
  
• Denaturation of dsDNA by p53
  
• 25 years after its discovery
  
• Monitoring p53's pulse
  
• In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
  
• Dynamics of the p53-Mdm2 feedback loop in individual cells
  
• RNA polymerase III transcription—a battleground for tumour suppressors and oncogenes
  
• Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
  
• On the excess of G→T transversions in the p53 gene in lung cancer cell lines
  
• Invariant p53 immunostaining in primary and recurrent breast cancer
  
• Conquering the complexity of p53
  
• Acute Ablation of Survivin Uncovers p53-dependent Mitotic Checkpoint Functions and Control of Mitochondrial Apoptosis