Autoimmune diseases and treatment



Autoimmune diseases and treatment
风湿病学家都熟知，自体免役性疾病是治疗难度很大的疾病。然而，在过去超过三十年的时间里，在这个领域里药物治疗取得的进展很少，让人失望。只是在最近五年左右时间里，人们才看到有针对性的治疗被引入。这其中的一个亮点就是，抗TNF制剂在临床上用来治疗风湿性关节炎，人们看到了病人在治疗后所取得的情况改善。但是这些药物长期应用的安全性仍是值得怀疑的。其他一些更特异的治疗剂，如抗-CD20、IL-6受体的抗体等等，也在试验之中，将来也许可以得到医师的青睐。同时研究者也发现，这些特异性的治疗也并非对所有人都有效。总之，目前对于自体免疫性疾病的治疗研究仍不尽人意，人们盼望有更大的突破出现。为此CMBI特搜集了关于Autoimmune diseases and treatment 的特别报道，供实践参考,更多文献,请用相关关键词通过CMBI文献查询获取。
Part I. Organ-Specific Autoimmune Diseases: Is PR3-ANCA Formation Initiated in Wegener's Granulomatosis Lesions Granulomas as Potential Lymphoid Tissue Maintaining Autoantibody Production Clinical Relevance of Antiphospholipid Antibodies in Primary Biliary Cirrhosis IL-10 and the Cytokine Network in the Pathogenesis of Human Autoimmune Hemolytic Anemia Crohn's Disease Is Associated with Polymorphism of CARD15NOD2 Gene in a Hungarian Population Apoptosis in Human Skin Cancer-Associated Myositis Clinical Features and Prognostic Signs Control of Type 1 Autoimmune Diabetes by Naturally Occurring CD4+CD25+ Regulatory T Lymphocytes in Neonatal NOD Mice The Role of Methallothioneins in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes and Autoantibodies in Patients with Type 2 Diabetes Mellitus Autoantibodies to Human 6 Integrin in Patients with Bullous Pemphigoid Soluble HLA Class I and Class II Molecules in Relapsing-Remitting Multiple Sclerosis Proinflammatory Cytokines and Autoimmunity in Churg-Strauss Syndrome Rheumatic Fever How S. pyogenes-Primed Peripheral T Cells Trigger Heart Valve Lesions Avidity of Anti-β2-Glycoprotein I and Thrombosis or Pregnancy Loss in Patients with Antiphospholipid Syndrome Neurological Complications of Celiac Disease and Autoimmune Mechanisms E2F1–– C57BL6 Mice Overexpressing a Human Bcl-2 Transgene in B Cells Develop a Mild Autoimmune Syndrome Systemic Thromboembolism in Inflammatory Bowel Disease Pregnancy Loss and Endometriosis Primary Biliary Cirrhosis The Stages of Type 1A Diabetes Soluble CD40L in Plasma of Patients with Primary Biliary Cirrhosis Decreased Serum Leptin Levels in Primary Biliary Cirrhosis Analysis of the Foxp3Scurfin Gene in Crohn's Disease Part II. Systematic Autoimmune Diseases: Juvenile Systemic Sclerosis Antifodrin Antibodies in Sjogren's Syndrome Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients Association of Rheumatoid Arthritis with HLA-DR1 and HLA-DR4 in Hungary Plasminogen Activator Inhibitor-1 Is Associated with Impaired Endothelial Function in Women with Systemic Lupus Erythematosus Early Atherosclerosis in Rheumatoid Arthritis Investigation of Arthritic Joint Destruction by a Novel Fibroblast-Based Model Prevalence of Antiphospholipid and Antioxidized Low-Density Lipoprotein Antibodies in Rheumatoid Arthritis Mono-organic versus Multi-organic Involvement in Primary Antiphospholipid Syndrome OxLDLβ2GPI Complexes and Autoantibodies in Patients with Systemic Lupus Erythematosus, Systemic Sclerosis, and Antiphospholipid Syndrome Anti-HSP60 Immunity Is Already Associated with Atherosclerosis Early in Life Determinants of Vessel Targeting in Vasculitis Lymphocyte Activation as a Possible Measure of Atherosclerotic Risk in Patients with Sleep Apnea Systemic Lupus Erythematosus, Atherosclerosis, and Autoantibodies Accelerated Atherosclerosis in Patients with Systemic Autoimmune Diseases Nocturnal Hormones and Clinical Rhythms in Rheumatoid Arthritis Xenobiotic-Induced Recruitment of Autoantigens to Nuclear Proteasomes Suggests a Role for Altered Antigen Processing in Scleroderma Humoral Antigenic Targets of the Ribosomal P0 Lupus Autoantigen Are Not Limited to the Carboxyl Region Clinical Correlations of Potential Activity Markers in Systemic Sclerosis Complement Activation A Novel Pathogenic Mechanism in the Antiphospholipid Syndrome The Interplay of Chemokines and Dendritic Cells in the Pathogenesis of Lupus Nephritis Cellular and Molecular Mechanisms of Regulation of Autoantibody Production in Lupus The Role of Innate and Adaptive Immunity to Oxidized Low-Density Lipoprotein in the Development of Atherosclerosis Predictive Markers for Development of Severe Organ Involvement in Patients with Systemic Sclerosis Hughes Syndrome, the Antiphospholipid Syndrome New Facet of Antiphospholipid Antibodies Part III. Treatment: Inhibitor Development in Patients with Hemophilia A after Continuous Infusion of FVIII Concentrates Increased Spontaneous Apoptosis of CD4+CD25+ T Cells in Patients with Active Rheumatoid Arthritis Is Reduced by Infliximab Synergistic Effect of Avemar on Proinflammatory Cytokine Production and Ras-Mediated Cell Activation Fermented Wheat Germ Extract (Avemar) in the Treatment of Cancer and Autoimmune Diseases Open-Label 24-Month Study Evaluating Infliximab Therapy in Patients with Psoriatic Spondyloarthropathy Cyclosporine From Renal Transplantation to Autoimmune Diseases Autoimmunity and Anti-TNF-Agents Comparative Analysis of Antigen Specificities in the Monomeric and Dimeric Fractions of Intravenous Immunoglobulin Combination Treatment of Rat Adjuvant-Induced Arthritis with Methotrexate, Probiotic Bacteria Enterococcus faecium, and Selenium Treatment of Pemphigus Vulgaris with Protein A Immunoadsorption Immunosuppressive Therapy and Clinical Evolution in Forty-nine Patients with Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis Management of Thrombosis in Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Pregnancy Gene-Gun Biolistic Immunization Encoding Glutamic Acid Decarboxylase Intra-bone Marrow-Bone Marrow Transplantation Removal of Pathogenic Autoantibodies by Immunoadsorption Chemokine Receptors Rationale for T Cell Inhibition by Cyclosporin A in Major Autoimmune Diseases Partial Response to Anti-CD20 Monoclonal Antibody Treatment of Severe Immune Thrombocytopenic Purpura in a Patient with Common Variable Immunodeficiency CD20 Mimicry by a mAb Rituximab-Specific Linear Peptide Anti-inflammatory and Immune Regulatory Properties of 5-Androsten-3β, 17β-Diol (HE2100), and Synthetic Analogue HE3204 Therapeutic T Cell-Based Vaccination for Neurodegenerative Disorders Tumor Necrosis Factor Inhibitor Therapy for Rheumatoid Arthritis Pathogenesis of Rheumatoid Arthritis Anticytokine Therapy, Especially Anti-Interferon-, as a Pathogenetic Treatment in TH-1 Autoimmune Diseases Immunomodulatory Effects of Intravenous Immunoglobulins as a Treatment for Autoimmune Diseases, Cancer, and Recurrent Pregnancy Loss Response of Vasculitic Peripheral Neuropathy to Intravenous Immunoglobulin Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases Do We Need New Treatment That Goes beyond Tumor Necrosis Factor Blockers for Rheumatoid Arthritis

Last Modified: 2005-10-23