gene expression



基因表达
基因表达、基因功能和基因调控不仅对人类基因组的结构及功能研究具有重要意义，而且对疾病的发病和防治亦具有重要的价值。基因表达作为医学分子生物学的中心环节，更具有重要的作用。本专题以 Science（22 October 2004 Vol. 306 No. 5696）的特别报导为基础，又搜集了最近发表的其它重要论文，较系统地介绍了基因表达的理论、技术和应用前景。为此CMBI特准备了关于基因表达的特别报道，供实践参考,更多文献,请用相关关键词通过CMBI文献查询获取。
Ca2+ regulation and gene expression in normal brain aging An mRNA amplification procedure with directional cDNA cloning and strand-specific cRNA synthesis for comprehensive gene expression analysis A comparison of gene expression profiles produced by SAGE, long SAGE, and oligonucleotide chips Genetics of disease-Bringing the role of mRNA decay in the control of gene expression into focus Vesnarinone-Mediated Alterations of Gene Expression in Cardiac Fibroblasts from Aortic Regurgitant Hearts Gene Expression Phenotypes of Atherosclerosis Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex Predicting drug response based on gene expression Distinctive Gene Expression Profiles by cDNA Microarrays in Endometrioid and Serous Carcinomas of the Endometrium Positional gene expression analysis identifies 12q overexpression and amplification in a subset of neuroblastomas Suppressive effects of nitric oxide production and inducible nitric oxide synthase (iNOS) gene expression by Calystegia soldanella methanol extract on lipopolysaccharide-activated RAW 264.7 cells A database for management of gene expression data in situ Analysis of the Major Histocompatibility Complex in Graft Rejection Revisited by Gene Expression Profiles. Modulation of gene expression by moxonidine in rats with chronic renal failure Predicting drug response based on gene expression Gene expression analysis of the critical period in the visual cortex Effect of ascorbic acid on hepatic vasoregulatory gene expression during polymicrobial sepsis The genomics of gene expression Regulation of ferrochelatase gene expression by hypoxia Gene expression changes accompanying p53 activity during estrogen treatment of osteoblasts Vesnarinone-Mediated Alterations of Gene Expression in Cardiac Fibroblasts from Aortic Regurgitant Hearts. Global Role for Chromatin Remodeling Enzymes in Mitotic Gene Expression Oligonucleotide microarray analysis of gene expression in neuroblastoma displaying loss of chromosome 11q. Circumvention of Normal Constraints on Granule Protein Gene Expression in Peripheral Blood Neutrophils and Monocytes of Patients with Autoantibody-Associated Glomerulonephritis Gene Expression Analysis of the Late Embryonic Mouse Cerebral Cortex Using DNA Microarray-Identification of Several Region-and Layer-specific Genes Long-term Transgene Expression from Plasmid DNA Gene Therapy Vectors Genetic analysis of genome-wide variation in human gene expression Obesity-induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus Modulation of Ras-Raf-Extracellular Signal–Regulated Kinase Pathway by Reactive Oxygen Species Is Involved in Cyclic Strain–Induced Early Growth Response-1 Gene Expression in Endothelial Cells Molecular Imaging of the Kinetics of Vascular Endothelial Growth Factor Gene Expression in Ischemic Myocardium NGF gene expression and secretion in white adipose tissue Profiling of Aortic Smooth Muscle Cell Gene Expression in Response to Chronic Inhibition of Nitric Oxide Synthase Gene expression profiles in human mesothelioma cell lines in response to interferon-γ treatment Hypoxic gene expression and metastasis Gene expression profiling after irradiation Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine 5' Long serial analysis of gene expression (LongSAGE) and 3' LongSAGE for transcriptome characterization and genome annotation Serial analysis of gene expression (SAGE)-unraveling the bioinformatics tools Translational Control Mechanisms Modulate Skeletal Muscle Gene Expression During Hypertrophy Transfer and Stable Transgene Expression of a Mammalian Artificial Chromosome into Bone Marrow-Derived Human Mesenchymal Stem Cells Characterization of the ovarian transcriptome through the use of differential analysis of gene expression methodologies Aberrant gene expression associated with recurrent pregnancy loss Quantitative Evaluation of Catecholamine Enzymes Gene Expression in Adrenal Medulla and Sympathetic Ganglia of Stressed Rats Molecular Regulation of Gene Expression of Catecholamine Biosynthetic Enzymes by Stress Enriched Environment Influences Adrenocortical Response to Immune Challenge and Glutamate Receptor Gene Expression in Rat Hippocampus Localization and Regulation of Phenylethanolamine N-Methyltransferase Gene Expression in the Heart Changes in Gene Expression of Phenylethanolamine N-Methyltransferase in the Transplanted Human Heart Angiotensin II AT1 Receptor Antagonism Downregulates Stress-Related Gene Expression in Brain Microvessels from Spontaneously Hypertensive Neural system-enriched gene expression- relationship to biological pathways and neurological diseases Single-Cell Gene Expression Analysis- Implications for Neurodegenerative and Neuropsychiatric Disorders Mining Microarrays for Metabolic Meaning- Nutritional Regulation of Hypothalamic Gene Expression Methodological Considerations Regarding Single-Cell Gene Expression Profiling for Brain Injury Large-Scale Analysis of Gene Expression in Epilepsy Research Gene Expression Profiling of Seizure Disorders Gene Expression Profiling in Fetal, Aged, and Alzheimer Hippocampus Gene Expression of Transcription Factors in the Rat Brain After Morphine Withdrawal Folate-Regulated Changes in Gene Expression in the Anterior Neural Tube of Folate Binding Protein-1 Prolonged biologically active transgene expression driven by HSV LAP2 in brainin A Quantitative Method for Measuring Gene Expression Magnitude and Volume Delivered by Gene Therapy Vectors Mouse testis transcriptome revealed using serial analysis of gene expression Deciphering Regulatory Patterns of Inflammatory Gene Expression From Interleukin-1—Stimulated Human Endothelial Cells Serial analysis of gene expression in mouse kidney following angiotensin II administration Gene expression profiling of potential PPAR target genes in mouse aorta Gene expression in humans with diabetes and prediabetes Fluctuation of chromatin unfolding associated with variation in the level of gene expression Genetic alteration and gene expression modulation during cancer progression Epigenetic and gene expression changes related to transgenerational carcinogenesis Engineered riboregulators enable post-transcriptional control of gene expression The mRNA cap-binding protein eIF4E in post-transcriptional gene expression Signaling pathway-related gene expression in neuroimmunoregulation Regulation of transgene expression in muscles by ultrasound-mediated hyperthermia Optimization of Ectopic Gene Expression in Skeletal Muscle through DNA Transfer by Electroporation Integrating Gene Expression and Metabolic Profiles A Versatile Assay for High-Throughput Gene Expression Profiling on Universal Array Matrices Gene Expression Profiling-From Microarrays to Medicine Cardiac-specific Knock-out of Lipoprotein Lipase Alters Plasma Lipoprotein Triglyceride Metabolism and Cardiac Gene Expression Heme Oxygenase-1 Gene Expression Modulates Angiotensin II-Induced Increase in Blood Pressure Global gene expression in human myocardium microarray in heart failure Real-time RT-PCR for gene expression profiling in blood of heart failure patients Day-night rhythms in gene expression of the normal murine heart Transcriptional regulation of FGF-2 gene expression in cardiac myocytes Linking Gene Expression to Function ACE2 gene expression is up-regulated in the human failing heart TGF-and TNF--antagonistic cytokines controlling type I collagen gene expression Regulation of heterochromatin by histone methylation and small RNAs Recent highlights of RNA-polymerase-II-mediated transcription Nonsense-mediated mRNA decay mRNA export-an assembly line from genes to nuclear pores miRNAs on the move-miRNA biogenesis and the RNAi machinery Dynamics of nuclear pore complex organization through the cell cycle Does protein synthesis occur in the nucleus Does looping and clustering in the nucleus regulate gene expression DNA damage checkpoint and repair centers Aging and nuclear organization-lamins and progeria The interplay of transcriptional and post-transcriptional mechanisms that regulate gene expression Mapping Global Histone Acetylation Patterns to Gene Expression Hypoxic gene expression and metastasis Gene expression profiling after irradiation Gene expression alterations over large chromosomal regions in cancers include multiple genes unrelated to malignant progression Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression Miniaturized fluorescent RNA dot blot method for rapid quantitation of gene expression Green fluorescent protein-green cells do not always indicate gene expression A gene expression system offering multiple levels of regulation Control of Stochasticity in Eukaryotic Gene Expression Gene expression of adenosine receptors along the nephron 10 Glucose regulation of HXT gene expression in the yeast Saccharomyces cerevisiae WebQTL-rapid exploratory analysis of gene expression and genetic networks for brain and behavior

Last Modified: 2004-11-21