Immunology of Diabetes

       　糖尿病是一种常见病、多发病，影响人类生活的主要疾病。cmbi曾经做过多篇相关报导。最近，在英国的剑桥举行了糖尿病免疫学会的第七次国际会议，将这次会议的报告内容汇编成册，定名为《糖尿病的免疫学Ⅲ》。本次会议参与人员主要是自身抗体与T细胞的专题研究人员。从发言或报告的论文集内容来看，T细胞的专题小组展示了当前糖尿病研究中的实质进展。本次会议涉及了糖尿病的多个重要方面，诸如卫生学假设，攻击过程中β细胞的基因表达，免疫调节，islet－cell转运现在是否是一个有理由的过程，生物信息学在I型糖尿病研究中的应用，以及II型糖尿病的免疫起源。有关I型糖尿病的动物和人模型的发言和招贴宣传也包括在内。本论文集所选编的内容涉猎了所有这些重要方面。为此CMBI特搜集了关于Immunology of Diabetes 的特别报道，供实践参考,更多文献,请用相关关键词通过CMBI文献查询获取。

Part I. Prevention of Type 1 Diabetes:
• Use of Anti-CD3 Monoclonal Antibody to Induce Immune Regulation in Type 1 Diabetes

 

Part II. T Cells in Type 1 Diabetes:

• Detection of Autoreactive T Cells in Type 1 Diabetes Using Coded Autoantigens and an Immunoglobulin-Free Cytokine ELISPOT Assay: Report from the Fourth Immunology of Diabetes Society T Cell Workshop
• CD4+ T Cell Proliferation in Response to GAD and Proinsulin in Healthy, Pre-diabetic, and Diabetic Donors
• Preproinsulin-Specific CD8+ T Cells Secrete IFN in Human Type 1 Diabetes
• Enhancing the Sensitivity of Assays to Detect T Cell Reactivity: The Effect of Cell Separation and Cryopreservation Media
• GAD-Reactive T Cells Were Mainly Detected in Autoimmune-Related Type 1 Diabetic Patients with HLA DR9

 

Part III. Immunology of Type 1 Diabetes:
• New Approaches for in Silico Identification of Cytokine-Modified ? Cell Gene Networks
• An Insulin-like Growth Factor 2-Derived Self-Antigen Inducing a Regulatory Cytokine Profile after Presentation to Peripheral Blood Mononuclear Cells from DQ8+ Type 1 Diabetic Adolescents: Preliminary Design of a Thymus-Based Tolerogenic Self-Vaccination
• Elevated Lymphocyte Expression of CLIP Is Associated with Type 1 Diabetes and May Be a Useful Marker of Autoimmune Susceptibility
• Differential Expression of Nonislet Autoimmunity: Comparison of Korean and U.S. Patients with Type 1 Diabetes
• Monocytic Expression Behavior of Cytokines in Diabetic Patients upon Inflammatory Stimulation
• Stromal Cell-Derived Factor-1 Chemokine Gene Variant in Patients with Type 1 Diabetes and Autoimmune Thyroid Disease
• Infant Vitamin D Supplementation and Allergic Conditions in Adulthood: Northern Finland Birth Cohort 1966

 

Part IV. Autoantibodies in Type 1 Diabetes:
• Is Type 1 Diabetes in the Japanese Population the Same as among Caucasians?
• Closer Association of IA-2 Humoral Autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D Patients
• Mothers' Attachment Insecurity and Diabetes-Related Autoantibodies in Their Infants
• Prevalence of Diabetes-Associated Autoantibodies in Schoolchildren: The Karlsburg Type 1 Diabetes Risk Study
• Prevalence of GAD65 Antibodies in Lean Subjects with Type 2 Diabetes
• Optimal Cutoff Point of Glutamate Decarboxylase Antibody Titers in Differentiating Two Subtypes of Adult-Onset Latent Autoimmune Diabetes
• No Association of INS-VNTR Genotype and IAA Autoantibodies
• Prevalence of Autoantibodies to Carbonic Anhydrase II and Lactoferrin in Patients with Type 1 Diabetes
• No Evidence of Pancreatic Autoimmunity among Patients with Multiple Sclerosis

 

Part V. Genetics of Type 1 Diabetes:
• Frequency of MICA in All Babies in Southeast Sweden (ABIS) Positive for High-Risk HLA-DQ Associated with Type 1 Diabetes
• IDDM17: Polymorphisms in the AMACO Gene Are Associated with Dominant Protection against Type 1A Diabetes in a Bedouin Arab Family
• MICA Gene Polymorphism in HBDI Multiplex Families
• A Second-Generation Genome Screen for Linkage to Type 1 Diabetes in a Bedouin Arab Family
• Killer Cell Immunoglobulin-like Receptor Genes in Latvian Patients with Type 1 Diabetes Mellitus and Healthy Controls
• Association of the Polymorphism for Toll-like Receptor 2 with Type 1 Diabetes Susceptibility

 

Part VI. Animal Models of Type 1 Diabetes:
• Molecular Pathways Altered by Insulin B9-23 Immunization
• 1,25-Dihydroxyvitamin D3 Alters the Profile of Bone Marrow-Derived Dendritic Cells of NOD Mice
• Establishment of Native Insulin-Negative NOD Mice and the Methodology to Distinguish Specific Insulin Knockout Genotypes and a B:16 Alanine Preproinsulin Transgene
• Immunohistochemical Demonstration of Nitrotyrosine, a Biomarker of Oxidative Stress, in Islet Cells of the NOD Mouse
• Identification of Keyβ Cell Gene Signaling Pathways Involved in Type 1 Diabetes
• Experimental Autoimmune Diabetes: A New Tool to Study Mechanisms and Consequences of Insulin-Specific Autoimmunity

 

Part VII. Informatics in Type 1 Diabetes:
• The Power of an Integrated Informatic and Molecular Approach to Type 1 Diabetes Research