Natural killer cells

       　自然杀伤细胞（Natural killer cell,NK)是来源于骨髓淋巴干细胞，其发育成熟依赖于骨髓和胸腺微环境。NK细胞主要分布于外周血和脾，在淋巴结和其他组织也有少量存在。前几年关于Nk细胞能溶解特定肿瘤细胞是NK的研究热点，期望能因此而找到恶性肿瘤的治疗途径。最近几年，关于NK细胞的其他功能，尤其是产生细胞因子的功能是另一个研究热点。NK细胞通过释放细胞因子能调节其他细胞（尤其是免疫系统的细胞）的活性。NK细胞的主要功能包括抗肿瘤、抗炎、调节造血系统、调节移植物抗宿主病、调节免疫和自身免疫以及在妊娠中的作用。鉴于NK细胞在病毒感染保护、调节免疫系统中的重要作用，我们增经在103期做过关于自然杀伤细胞的特别报道。为此CMBI特准备了关于Natural killer cells的特别报道，供实践参考。更多文献,请用相关关键词通过CMBI文献查询获取。

• The cell biology of the human natural killer cell CD94-NKG2A inhibitory receptor
  
• Shaping the human NK cell repertoire-an epigenetic glance
  
• PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor
  
• Proteomic analysis of human natural killer cells
  
• Peripheral NK cell phenotypes
  
• NK cell regulation of T cell-mediated responses
  
• Natural killer cells infiltrating colorectal cancer and MHC class I expression
  
• Mouse Ly49 NK receptors
  
• Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1
  
• Lymphotoxin α1β2-a critical mediator in Vα14i NKT cell differentiation
  
• KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation
  
• KIR allele and gene polymorphism group
  
• Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells
  
• Immunogenetics of killer cell immunoglobulin-like receptors
  
• Human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation
  
• Helper role of NK cells during the induction of anticancer responses by dendritic cells
  
• Cross-talk between dendritic cells and natural killer cells in viral infection
  
• Coordination of activating and inhibitory signals in natural killer cells
  
• Computational modeling of human natural killer cell development suggests a selection process regulating coexpression of KIR
  
• Compartmentalization of human natural killer cells
  
• Activation of NK cell cytotoxicity
  
• 2B4 co-stimulation-NK cells and their control of adaptive immune responses
  
• 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells
  
• Natural killer cells
  
• Role of trans-cellular IL-15 presentation in the activation of NK cell–mediated killing, which leads to enhanced tumor immunosurveillance
  
• p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells
  
• INHIBITORY NK-CELL RECEPTORS ON T CELLS-WITNESS OF THE PAST, ACTORS OF THE FUTURE
  
• The Dynamic Life of Natural Killer Cells
  
• The Dynamic Life of Natural Killer Cells
  
• Mhc Class-Receptors On Natural Killer Cells-On With The Old And In With The New
  
• Turning On Natural Killer Cells
  
• Natural killer cells can mediate cardiac allograft vasculopathy
  
• Natural killer cells and viral infections
  
• In Vivo Survival and Homeostatic Proliferation of Natural Killer Cells
  
• WHAT DOES IT TAKE TO MAKE A NATURAL KILLER
  
• Vital Involvement of a Natural Killer Cell Activation Receptor in Resistance to Viral Infection
  
• ULBP4 is a novel ligand for human NKG2D
  
• Turning On Natural Killer Cells
  
• The NKG2D receptor and its ligands
  
• The NK cell receptor repertoire
  
• The choices of a natural killer
  
• STRUCTURE AND FUNCTION OF NATURAL KILLER CELL RECEPTORS
  
• Specific and nonspecific NK cell activation during virus infection
  
• REGULATION OF THE NATURAL KILLER CELL RECEPTOR REPERTOIRE
  
• Regulation of antiviral CD8+ T cells by inhibitory natural killer cell receptors
  
• Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis
  
• On guard-activating NK cell receptors
  
• NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway
  
• NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
  
• NK-cell activity in immunotoxicity drug evaluation
  
• NK CELL RECEPTORS
  
• Natural killer cells can mediate cardiac allograft vasculopathy
  
• Natural killer cells and viral infections
  
• Mouse V14i natural killer T cells are resistant to cytokine polarization in vivo
  
• Innate immunity
  
• Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
  
• In Vivo Survival and Homeostatic Proliferation of Natural Killer Cells
  
• IL-15 availability conditions homeostasis of peripheral natural killer T cells
  
• HIV-1 Antiviral Activity of Recombinant Natural Killer Cell Enhancing Factors, NKEF-A and NKEF-B
  
• Genes encoding putative natural killer cell C-type lectin receptors
  
• Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines
  
• Crystal structure of the murine NK cell-activating receptor NKG2D
  
• Activation of Natural Killer (NK) T Cells during Murine Cytomegalovirus Infection
  
• ACTIVATING RECEPTORS AND CORECEPTORS INVOLVED IN HUMAN NATURAL KILLER CELL-MEDIATED CYTOLYSIS
  
• Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
  
• CTLs, a novel HLA-E-restricted T-cell subset