RNA mapping和RNAi therapy

       　继人类基因组计划完成后，RNA又成为分子生物学研究的一个新的热点和焦点，在短短几年内已取得突破性的进展，从2002年起miRNA、SiRNA和RNAi分子连续几年一直被Nature、Science评为生物医学中最闪耀的明星分子。具有极其重要的理论和实际应用的意义和广阔发展前景，它还成为医学生物学研究的一个不可替代和普遍应用的工具，它亦将会成为攻克肿瘤、心血管病、传染性疾病等疑难顽症最锐利的武器。为此cmbi曾在41、70、182期作了特别报导。最近，又组织了RNA mapping和RNAi therapy的特别报导，供实践参考。更多文献,请用相关关键词通过CMBI文献查询获取。

• The Functional Genomics of Noncoding RNAs
  
• The Complex Lives of Eukaryotic mRNAs
  
• RNA Structure-Reading the Ribosome
  
• Ribo-gnome-The Big World of Small RNAs
  
• It's a Small RNA World, After All
  
• Fewer Genes, More Noncoding RNAs
  
• Capping by Branching-A New Ribozyme Makes Tiny Lariats
  
• In the Forests of RNA Dark Matter
  
• Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
  
• Unlocking the money-making potential of RNAi
  
• Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
  
• The role of small RNAs in human diseases
  
• The prospect of silencing disease using RNA interference
  
• The promise of siRNAs for the treatment of influenza
  
• siRNA therapeutics
  
• silencing of disease genes with RNA interference
  
• Silencing mutant SOD1 using RNAi protects against neurodegeneration
  
• short RNAs that silence gene expression
  
• Short interfering RNAs as a tool for cancer gene therapy
  
• Sequence-specific potent induction of IFN-a by short interfering RNA in plasmacytoid dendritic cells
  
• Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
  
• RNAi suppresses polyglutamineinduced neurodegeneration in a model of spinocerebellar ataxia
  
• Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes
  
• RNA-mediated gene silencing
  
• RNA-interference-based functional genomics in mammalian cells
  
• RNA interference-a potential novel therapeutic combating HIV-1 in the central nervous system
  
• RNA interference-small RNAs effectively fight viral hepatitis
  
• RNA interference--significance and applications
  
• RNA interference-the silent treatment
  
• RNA interference and potential therapeutic applications of short interfering RNAs
  
• RNA interference and nonviral targeted gene therapy of experimental brain cancer
  
• Progress toward the therapy of hepatitis with RNAi
  
• Post-transcriptional gene silencing by siRNAs and miRNAs
  
• New tools for functional mammalian cancer genetics
  
• New technologies deliver in treating neurological diseases
  
• Lentiviral-mediated silencing of SOD1 through RNA interference retards disease in ALS
  
• Lack of interferon response in animals to naked siRNAs
  
• Interfering with hepatitis C virus RNA replication
  
• Inhibition of respiratory viruses by nasally administered siRNA
  
• Inhibition of hepatitis B virus in mice by RNA interference
  
• Hopes rise for RNA therapy as mouse study hits target
  
• Exploring plant genomes by RNA-induced gene silencing
  
• endogenous siRNAs and miRNAs
  
• Downregulating gene expression-the impact of RNA interference
  
• Dissecting HIV-1 through RNA interference
  
• Control of HIV-1 replication by RNA interference
  
• Complete, gene-specific siRNA libraries
  
• can RNA interference be exploited for therapy
  
• Application of siRNA in Cancer Target
  
• advances in RNA interference in oncology
  
• Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication
  
• A crucial test
  
• a cholesterol connection in RNAi
  
• RNA interference in adult mice