Nitric Oxide (Ⅱ)

       　NO它是一种新型生物信使分子，广泛分布于生物体内各组织中，1992年被美国Science杂志评选为明星分子。NO具有舒张血管、降低血压、抑制平滑肌细胞增殖和血小板黏附，参与免疫反应、杀灭肿瘤细胞和微生物等重要的生理作用；在高血压、心肌缺血、脑卒中等许多心血管疾病的发病和自身免疫性疾病、退行性疾病及炎症的发生演变中具有重要的临床意义。NO功能失调是导致心脑血管疾病发生发展的重要因素。我们曾经在50期做过一氧化氮的特别报道，近年来NO的研究又取得了新的进展。为此CMBI特准备了关于Nitric Oxide (Ⅱ)的特别报道，供实践参考。更多文献,请用相关关键词通过CMBI文献查询获取。

• Time course of flow-induced vasodilation in skeletal muscle
  
• The role of nitric oxide in cardiovascular diseases
  
• The Nitric Oxide-Endothelin-1 Connection
  
• The basics about nitric oxide
  
• Systemic arterial pressure response to two weeks of Tempol therapy in SHR
  
• Overexpression of Dimethylarginine Dimethylaminohydrolase Reduces Tissue Asymmetric Dimethylarginine Levels and Enhances Angiogenesis
  
• Nitric Oxide, Atherosclerosis and the Clinical Relevance of Endothelial Dysfunction
  
• Nitric oxide promotes in vitro interstitial cell heart valve repair
  
• Nitric oxide in physiology and pathology-The role of nitric oxide in cardiovascular diseases
  
• Nitric oxide in physiology and pathology-The basics about nitric oxide
  
• Nitric oxide in physiology and pathology-Biology and chemistry of the inhibition of nitric oxide synthases by therapeutic agents
  
• Nitric oxide in physiology and pathology-Application of pharmaceuticals to nitric oxide
  
• Nitric oxide in physiology and pathology
  
• Nitric oxide and neurological disorders
  
• Nitric Oxide and Cardiovascular Protection
  
• Different Involvement of Extracellular Matrix Components in Small and Large Arteries During Chronic NO Synthase Inhibition
  
• Delayed cerebral vasospasm and nitric oxide
  
• Application of pharmaceuticals to nitric oxide
  
• Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes
  
• Overexpression of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla Causes Hypertension and Sympathoexcitation via an Increase in Oxidative Stress
  
• Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors
  
• Nitric oxide's role in the heart
  
• Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling
  
• The Cell-specific Expression of Endothelial Nitric-oxide Synthase
  
• Biological activity of nitric oxide in the plasmatic compartment
  
• Nitric oxide's role in the heart- control of beating or breathing
  
• nNOS at a glance
  
• Nitrosylhemoglobin formation after infusion of NO solutions
  
• Nitric oxide's role in the heart
  
• Nitric oxide synthase activity in rat cardiac mitochondria
  
• Nitric oxide represses inhibitory B kinase through S-nitrosylation
  
• Nitric oxide and the enigma of cardiac hypertrophy
  
• iNOS (NOS2) at a glance
  
• Heme Distortion Modulated by Ligand-Protein Interactions in Inducible Nitric-oxide Synthase
  
• eNOS at a glance
  
• Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives
  
• Nitric oxide synthase activity in rat cardiac mitochondria
  
• Nitric oxide-inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression
  
• Measurements of nitric oxide concentration and hyporeactivity in rat superior mesenteric artery exposed to endotoxin
  
• Inhibition of Inducible Nitric-oxide Synthase by Activators of AMP-activated Protein Kinase
  
• Increased neuronal nitric oxide synthase-derived NO production in the failing human heart
  
• Evidence of Two Distinct Oxygen Complexes of Reduced Endothelial Nitric Oxide Synthase
  
• Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase
  
• Defective Lung Vascular Development and Fatal Respiratory Distress in Endothelial NO Synthase-Deficient Mice
  
• Role of eNOS in neovascularization-NO for endothelial progenitor cells
  
• Role of endothelial nitric oxide synthase in endothelial activation
  
• Regulation of Endothelial Nitric Oxide Synthase by PPAR Agonists-Molecular and Clinical Perspectives
  
• Rapid Regulation of Platelet Activation In Vivo by Nitric Oxide
  
• Asymmetrical Dimethylarginine
  
• Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease
  
• Nitric oxide-inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression
  
• Hemoglobin and the Paracrine and Endocrine Functions of Nitric Oxide
  
• Heart mitochondrial nitric oxide synthase
  
• Therapeutic interventions targeting the nitric oxide system
  
• Regulation of Endothelial Nitric Oxide Synthase by Tetrahydrobiopterin in Vascular Disease
  
• Nitric oxide, oxidants, and protein tyrosine nitration
  
• Nitric oxide and homeostatic control
  
• Endothelial Nitric Oxide Synthase-A New Paradigm for Gene Regulation in the Injured Blood Vessel
  
• Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media
  
• Nitric Oxide Production and Regulation of Endothelial Nitric-oxide Synthase Phosphorylation by Prolonged Treatment with Troglitazone
  
• Modulation of In Vivo Cardiac Function by Myocyte-Specific Nitric Oxide Synthase-3
  
• Inhibition of Apoptosis Signal-regulating Kinase 1 by Nitric Oxide through a Thiol Redox Mechanism
  
• Exhaled Nitric Oxide in Pathophysiologic States
  
• Dynamic Regulation of the Inducible Nitric-oxide Synthase by NO
  
• Understanding isoform-selective inhibition of NOS
  
• Multiple-center, randomized, placebo-controlled, double-blind study of NOS inhibitor
  
• Heat shock protein 90 and tyrosine kinase regulate eNOS NO· generation
  
• NO-dependent protein nitration
  
• Cardiovascular effects of the nitric oxide synthase inhibitor in septic shock