proteome



Proteome
蛋白质组学在本质上指的是在大规模水平上研究蛋白质的特征，包括蛋白质的表达水平，翻译后的修饰，蛋白与蛋白相互作用等，由此获得蛋白质水平上的关于疾病发生，细胞代谢等过程的整体而全面的认识。蛋白质组学的研究是一项系统性的多方位的科学探索。其研究内容包括：蛋白质结构、蛋白质分布、蛋白质功能、蛋白质的丰度变化、蛋白质修饰、蛋白质与蛋白质的相互作用、蛋白质与疾病的关联性。研究蛋白质组学,需要用新的技术较大规模的研究蛋白质组的功能。蛋白质组学将基因、蛋白质及疾病联系起来，可应用于对许多疾病机理的研究，并且在研制、开发临床药物方面具有很大前景。为此CMBI特准备了关于proteome的特别报道，供实践参考,更多文献,请用相关关键词通过CMBI文献查询获取。
Proteomic Analysis of in Vivo Phosphorylated Synaptic Proteins Proteomic analysis of cancer-cell mitochondria Proteomic analysis for the early detection and rational treatment of cancer High-Throughput Screening-High-throughput proteome-screening for biomarker detection potential opportunities for clinical and physiological investigators The role of the proteome in catalysis and regulation Emerging classes of protein–protein interaction inhibitors and new tools for their development Use of functional proteomics to investigate PKC epsilon-mediated cardioprotection Toward high-throughput structural biology as a tool in functional genomics The proteomics bottleneck Proteomics Proteomics techniques and their application to hematology Proteomics in Cardiovascular Biology and Medicine Proteomics in Alzheimer's disease Proteomics-current techniques and potential applications to lung disease Proteomics-advanced technology for the analysis of cellular function Proteomic map and database of lymphoblastoid proteins Proteomic capacity of recent fluorescent dyes for protein staining Proteomic and Metabolomic Analysis of Vascular Smooth Muscle Cells Proteomic analysis of rat atrial secretory granules Proteomic analysis of post-mitochondrial fractions of young and old rat kidney Proteomic Analysis of Pharmacologically Preconditioned Cardiomyocytes Reveals Novel Phosphorylation of Myosin Light Chain 1 Proteome analysis at the level of subcellular structures ProMate-A Structure Based Prediction Program to Identify the Location of Protein–Protein Binding Sites PRISM-a new strategy to analyze the mammalian proteome Platelet proteomics Organelle proteomics National Heart, Lung, and Blood Institute Clinical Proteomics Working Group Report Multiprotein signaling complexes and regulation of cardiac phenotype Multidimensional proteomics Methods for on-chip protein analysis Mass spectral analysis in proteomics ivascience improves proteome detection Intracellular antibodies for proteomics Increasing specificity in high-throughput yeast two-hybrid experiments Implications for Subcellular Fractionation in Proteomics Identification of Novel Signaling Complexes by Functional Proteomics Identification by a Differential Proteomic Approach of Heat Shock Protein 27 as a Potential Marker of Atherosclerosis Human protein reference database as a discovery resource for proteomics Global approaches to protein–protein interactions Genomics-Proteomics and Stroke Genomics, proteomics and bioinformatics of human heart failure Genomics and proteomics in cancer Genomic and Proteomic Profiles of Heart Disease Future Targets and Cascades for Neuroprotective Strategies Functional proteomics mapping of a human signaling pathway Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection Functional Proteomic Analysis of Protein Kinase C Signaling Complexes in the Normal Heart and During Cardioprotection Functional Proteomic Analysis of Protein Kinase C Signaling Complexes in Preconditioning Full text Proteomics and Cardiovascular Disease From functional genomics to systems biology Evolving protein interaction networks through gene duplication Evolving new genetic codes Enhanced functional information from predicted protein networks Combining mass spectrometry with database interrogation strategies in proteomics- Combining mass spectrometry with database interrogation strategies in proteomics Clinically Translated Ischemic Stroke Genomics Chemical strategies for functional proteomics Chemical strategies for activity-based proteomics Cardiovascular Proteomics-Evolution and Potential Proteome database of hepatocellular carcinoma Bioinformatics support for high-throughput proteomics Applied Proteomics-Mitochondrial Proteins and Effect on Function Applications of affinity chromatography in proteomics Application of genomics and proteomics in Type 1 diabetes pathogenesis research Analysis of protein interactions using fluorescence technologies Analysis of complex protein-polypeptide systems for proteomic studies An object model and database for functional genomics Acute-Phase Proteins Before Cerebral Ischemia in Stroke-Prone Rats-Identification by Proteomics Proteomic analysis for the early detection and rational treatment of cancer-realistic hope Gaining confidence in high-throughput protein interaction networks Applying proteomics to signaling networks Comparative analysis of the proteome of left ventricular heart of arteriosclerosis Application of Proteomics to the Study of Platelet Regulatory Mechanisms MASS SPECTRAL ANALYSIS IN PROTEOMICS- Anchor residues in protein–protein interactions A Proteomic Study of SUMO-2 Target Proteins A proteomic approach for the discovery of protease substrates How a G Protein Binds a Membrane Functional Proteomics Mapping of a Human Signaling Pathway Evidence for dynamically organized modularity in the yeast protein–protein interaction network Dissection of the Mammalian Midbody Proteome Reveals Conserved Cytokinesis Mechanisms Comprehensive Proteomic Analysis of Interphase and Mitotic 14-3-3-binding Proteins Unimod- Protein modifications for mass spectrometry Two-dimensional maps and databases of the human macrophage proteome and secretome The RESID Database of Protein Modifications as a resource and annotation tool The Phosphorylation Site Database Readout of protein microarrays using intrinsic time resolved UV fluorescence for label-free detection ProteoMod A new tool to quantitate protein post-translational modifications 1 Proteomic characterization of novel serum amyloid P component variants from human plasma and urine Proteomic analysis of mouse mammary terminal end buds identifies axonal growth cone proteins Proteomic analysis of adipocyte differentiation proteome analysis by combining improved N-terminal sulfonation for de novo peptide sequencing Predotar- A tool for rapidly screening proteomes for N-terminal targeting sequences Prediction of the subcellular localization of eukaryotic proteins using sequence signals and composition Prediction of sequence signals for lipid post-translational modifications Prediction of protein-protein interactions based on surface patch comparison Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence Prediction of disulfide-bonded cysteines in proteomes with a hidden neural network ( PhosphoSite- A bioinformatics resource dedicated to physiological protein phosphorylation N-Terminal myristoylation predictions by ensembles of neural networks Mapping of bovine skeletal muscle proteins using two-dimensional gel electrophoresis and mass spectrometry Has the yo-yo stopped- An assessment of human protein-coding gene number Functional protein nanoarrays for biomarker profiling Fine-tuning the prediction of sequences cleaved by signal peptidase II Dispensable role for interferon- in the burn-induced acute phase response Development of a mass fingerprinting tool for automated interpretation of oligosaccharide Characterization and location of post-translational modifications on chromogranin B from Annotation of post-translational modifications in the Swiss-Prot knowledge base Advances in the prediction of protein targeting signals Post-translational modifications-A challenge for proteomics and bioinformatics Activity-based probes for the proteomic profiling of metalloproteases Detection of Differentially Expressed Proteins in Early-Stage Melanoma Patients Clinical Proteomics and Biomarker Discovery Cancer Proteomics- Serum Diagnostics for Tumor Marker Discovery A Serum Proteomics Approach to the Diagnosis of Ectopic Pregnancy Proteomic research-potential opportunities for clinical and physiological investigators Proteomic diagnostics tested Protein–Protein Interologs and Protein–DNA Regulogs Predicting indirect readout effects in protein–DNA interactions MASS SPECTRAL ANALYSIS IN PROTEOMICS Environmental signatures in proteome properties Quantitative Proteomics of the Thyroid Hormone Receptor-Coregulator Interactions Automatic Identification of Subcellular Phenotypes on Human Cell Arrays Serum Proteomics in Cancer Diagnosis and Management Functional proteomic screens reveal an essential extracellular role for hsp90 in cancer cell invasiveness Predicting protein partners Bayesian method for identifying missing enzymes in predicted metabolic pathway databases Towards a standardized human proteome database Towards a standardized human proteome database Prediction of protein function and pathways in the genome era Improving large-scale proteomics by clustering of mass spectrometry data Functional and topological characterization of protein interaction networks Computational approaches to structural and functional analysis of plastocyanin Novel aspects of macromolecular repair and relationship to human disease Proteomics analysis of human endothelial cell line Intregrated analysis of the human cardiac transcriptome, proteome and phosphoproteome Stochastic model of protein–protein interaction-Why signaling proteins need to be colocalized Prediction of protein function and pathways in the genome era Network motifs in integrated cellular networks of transcription–regulation and protein–protein interaction Functional classification of proteins and protein variants Computational redesign of protein-protein interaction specificity Analyzing protein-protein interactions in cell membranes A Functional Protein Chip for Pathway Optimization and in Vitro Metabolic Engineering Proteomic mapping provides powerful insights into functional myelin biology Troponin T as a marker of differentiation revealed by proteomic analysis in renal arterioles National Heart, Lung, and Blood Institute Clinical Proteomics Working Group Report An R111C Polymorphism in Wild Turkey Cardiac Troponin I Accompanying the Dilated Cardiomyopathy Analysis of Serum Proteomic Patterns for Early Cancer Diagnosis Mapping gene ontology to proteins based on protein–protein interaction data transcription factor complexes during erythroid differentiation revealed by quantitative proteomics Protein nanocrystallography-a new approach to structural proteomics protein folding-Solvation in protein folding analysis Fractionation of peptides in proteomics with the use of pI-based approach and ZipTip pipette tips An Oriented Peptide Array Library (OPAL) Strategy to Study Protein-Protein Interactions A Novel Proteomic Screen for Peptide-Protein Interactions Computational Alanine Scanning of Protein-Protein Interfaces Two-dimensional Blue Native-SDS Gel Electrophoresis of Multi-Protein Complexes from Whole Cellular Lysates-A PROTEOMICS APPROACH The role of loop 7 in mediating calcineurin regulation The Promise of Disease Proteomics-Faster Detection, Diagnosis, and Drug Development The mRNA Export Factor Human Gle1 Interacts with the Nuclear Pore Complex Protein Nup155 Protein Identification by Mass Spectrometry protein folding-Stepwise helix formation and chain compaction during protein folding protein fold recognition based on secondary structure, sequence similarity and enzyme classification Prediction of proprotein convertase cleavage sites Peroxisomal Targeting as a Tool for Assaying Protein-Protein Interactions in the Living Cell On the rotational operators in protein structure simulations Mass Spectrometric Approaches Using Electrospray Ionization Charge States and Hydrogen-Deuterium Exchange for Determining Protein Structures and Their Conformational Changes Integration of Proteomics and Genomics in Platelets imm-Expression Profiling of Lymphocyte Plasma Membrane Proteins Identification of the Substrates and Interaction Proteins of Aurora Kinases from a Protein-Protein Interaction Model HysTag—A Novel Proteomic Quantification Tool Applied to Differential Display Analysis of Membrane Proteins HysTag—A Novel Proteomic Quantification Tool Applied to Differential Display Analysis of Membrane Proteins From Distinct Areas F-actin Capping (CapZ) and Other Contractile Saphenous Vein Smooth Muscle Proteins Are Altered by Hemodynamic Stress-A PROTEOMIC APPROACH Expression Profiling of Lymphocyte Plasma Membrane Proteins Emerging Protein Interaction Technologies Applied to Signaling Networks Creating new peptide antigens by slicing and splicing proteins Complementary Analysis of the Mycobacterium tuberculosis Proteome by Two-dimensional Electrophoresis and Isotope-coded Affinity Tag Technology A novel fingerprint for the characterization of protein folds Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct Fatty Acid Binding Protein as a Serum Marker for the Early Diagnosis of Stroke Proteomic Analysis of Oxidative Stress-resistant Cells Serum Proteomics in Cancer Diagnosis and Management Proteomic evaluation of core biopsy specimens from breast lesions Proteomic Analysis to Clinical Significance-Overexpression of Cytokeratin 19 Correlates with Hepatocellular Carcinoma Metastasis From Proteomic Analysis to Clinical Significance-Overexpression of Cytokeratin 19 Correlates with Hepatocellular Carcinoma Metastasis Comparison of Proteomic and Genomic Analyses of the Human Breast Cancer Cell Line Unraveling protein interaction networks with near-optimal efficiency Strain-specific Kinetics of Prion Protein Formation in Vitro and in Vivo Recent patent applications in proteomics Proteomic Analysis of Rat Liver Peroxisome Protein topology determines binding mechanism Proteomics Analysis of Rat Brain Postsynaptic Density Interplay of transcriptomics and proteomics Gaining confidence in high-throughput protein interaction networks Mating antibody phage display with proteomics

Last Modified: 2005-02-07