大鼠基因组
The Brown Norway rat (Rattus
norvegicus)是第3个(前两个是人类和小鼠)被完成全基因组序列测定的哺乳动物，最新一期的Nature公布了这项研究结果。大鼠在实验医学和药物开发中扮演重要角色，用于从心血管疾病到空间运动疾病的生理、药理学研究；用于模拟几乎每一种已知的人类疾病。因此大鼠全基因组序列测定的完成将有助于发现疾病相关基因、以及疾病基因和环境相互作用而影响健康的机制。发表在Nature上的大鼠全基因组序列测定结果约有25000个基因，其中约90％
与人类和小鼠相匹配，即几乎所有已知人类疾病基因在大鼠中有相应的基因，因此人类可以更好地利用大鼠作为疾病模型。大鼠和小鼠共有约10％的基因是人类所没有的，这些基因编码与嗅觉相关的蛋白质，这也许就是啮齿类动物嗅觉灵敏的原因。大鼠全基因组序列测定的完成对于医学研究和进一步理解生物进化有重要意义。CMBI曾在特别报道之68期有过关于小鼠基因组的特别报道，现将大鼠基因组的最新报告集结成辑供研究参考，更多文献请用相关关键词通过CMBI文献查询获取。
- Rat genome unveiled
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- Genome sequence of the Brown Norway rat yields insights into mammalian evolution
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Primary Report
Links Out
Last Modified: 2004-04-02