The Communicative Cardiac Cell

       　细胞内与细胞间的信息交流对于维持一个有机体的生命与正常功能是不可缺少的，一个细胞总是在不断地对细胞外的离子与分子信号做出反应，同时细胞个体与细胞群体的行为也在受着这些信号的协调。每一个信号通路都是一个复杂的相互作用网络的缘起和效应链，重现细胞的信号传导框架和这些复杂作用现象的限制因素，将有助于了解包括维持生命在内的复杂现象的产生原因。本卷收录的内容将集中于展现引发效应器系统特定应答的信号诱导的相互作用。因此CMBI特搜集了关于The Communicative Cardiac Cell 的相关资料，供实践参考。更多文献，请用相关关键词通过CMBI文献查询获取。

Part I. Prologue:
• From Organ to Molecules Steps and Consequences

 

Part II. Cardiac Cell Development:

• Evolution of the Heart from Bacteria to Man
• Multiple Stem Cell Populations Contribute to the Formation of the Myocardium
• The Miscommunicative Cardiac Cell
• Functional Properties of Human Embryonic Stem Cell-Derived Cardiomyocytes
• Differentiation Pathways in Human Embryonic Stem Cell-Derived Cardiomyocytes

 

Part III. Calcium Signaling:
• The Assembly of Calcium Release Units in Cardiac Muscle
• Calcium Signaling in Cardiac Ventricular Myocytes
• Calcium Biology of the Transverse Tubules in Heart
• Multimodality of Ca2+ Signaling in Rat Atrial Myocytes
• Effects of Na+-Ca2+ Exchange Expression on Excitation-Contraction Coupling in Genetically Modified Mice
• Mitochondrial Calcium Signaling and Energy Metabolism
• Rhythmic Ca2+ Oscillations Drive Sinoatrial Nodal Cell Pacemaker Function to Make the Heart Tick

 

Part IV. Intracellular Signaling:
• Modification of Cellular Communication by Gene Transfer
• Caveolae and Lipid Rafts
• Nitric Oxide and the Heart
• Cardiac Neurobiology of Nitric Oxide Synthases
• The Murine Cardiac 26S Proteasome

 

Part V. Energetics and Transport:
• Metabolic Energetics and Genetics in the Heart
• The Sarcomeric Control of Energy Conversion
• Structure-Function Relation of the Myosin Motor in Striated Muscle
• Mitochondria and IschemiaReperfusion Injury
• Regulation of Cardiac Energetics
• Spatial Regulation of Intracellular pH in the Ventricular Myocyte

 

Part VI. Electromechanical Interactions and Modeling:
• Cardiac Systems Biology
• Measuring and Mapping Cardiac Fiber and Laminar Architecture Using Diffusion Tensor MR Imaging
• Electrotonic Cell-Cell Interactions in Cardiac Tissue
• Modulation of Transmural Repolarization
• Species-and Preparation-Dependence of Stretch Effects on Sino-Atrial Node Pacemaking
• Dependence of Electrical Coupling on Mechanical Coupling in Cardiac Myocytes
• Spatial Nonuniformity of Contraction Causes Arrhythmogenic Ca2+ Waves in Rat Cardiac Muscle

 

Part VII. Novel Therapeutics for the Failing and Arrhythmogenic Cardiac Cell:
• Ryanodine Receptor-Targeted Anti-Arrhythmic Therapy
• Stem Cells for Cardiomyocyte Regeneration
• Extracellular Stimulation in Tissue Engineering

 

Part VIII. Epilogue: A View into the Future:
• Multiscale Modeling of Cardiac Cellular Energetics